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Jennerex Presents Clinical Data From JX-594 Demonstrating Tumor Efficacy Against Advanced Liver Cancers
Date:10/23/2007

Positive Results Prompt Phase 2 Trial of JX-594 in Liver and Head and Neck

Cancers

SAN FRANCISCO, Oct. 23 /PRNewswire/ -- Jennerex Biotherapeutics today presented clinical data from a Phase 1 / 2 trial of JX-594 -- the company's proprietary targeted lytic and immunostimulatory armed virus therapy -- demonstrating objective evidence of efficacy in 10 of the 13 evaluable patients with advanced treatment-refractory tumors in the liver (primary and metastatic). Responses were particularly encouraging in primary liver (HCC) cancers, squamous cell cancers (including lung) and melanoma. All three patients with primary liver cancer had evidence of efficacy, including tumor marker decreases of 65, 80 and 98 percent.

Seven patients survived for at least eight months (double the life expectancy), and four are still alive up to 17 months post-treatment; two are alive over one year. Importantly, JX-594 was shown to be generally well tolerated in the Phase 1 / 2 study. These data were presented today by David H. Kirn, M.D., CEO and President of Jennerex at the AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics Conference in San Francisco, California.

"We are extremely encouraged by these results, particularly with respect to the effectiveness of JX-594 against liver cancers and squamous cell cancers including lung cancer," said Herbert M. Pinedo, M.D., board member and former president of the European Society of Medical Oncology.

"The survival of many of these patients is remarkable, in particular those who had major tumor responses. This has great promise for many cancer types, starting with liver and head and neck cancers," said the study's principal investigator, Dr. B-H Park, Chief, Interventional Radiology, DAU University, South Korea.

Following on these results, Jennerex is initiating a Phase 2a clinical trial in the United States for hepatocellular (liver) carcinoma at leading cancer centers inclu
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SOURCE Jennerex Biotherapeutics
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