Navigation Links
Jennerex Completes the Treatment of First Patient Cohort in Phase 1 Trial With Intravenous Delivery of JX-594 Oncolytic Virus
Date:10/15/2008

ed patients were end-stage and had no effective therapies available. JX-594 multiplies selectively within cancer cells, leading to their destruction. These newly created copies of JX-594 are then released and are able to infect and eradicate other tumor cells both locally and in distant sites in the body. This cycle of JX-594 replication, cancer cell destruction, release and spread is then repeated. Normal cells are not affected by JX-594 resulting in safety and tolerability. The poxvirus strain backbone of JX-594 has been used safely in millions of people as part of a worldwide vaccination program. This strain naturally targets cancer cells due to common genetic defects in cancer cells. JX-594 was engineered to enhance this natural safety and cancer-selectivity by deleting its thymidine kinase (TK) gene, thus making it dependent on the cellular TK expressed at persistently high levels in cancer cells. To enhance product efficacy, JX-594 is also engineered to express the GM-CSF protein. GM-CSF complements the cancer cell lysis work of the product candidate, leading to a cascade of events resulting in tumor necrosis, tumor vasculature shutdown and an anti-tumoral immune attack.

About Jennerex

Jennerex Biotherapeutics was established in San Francisco and in Ottawa in 2006 with Dr. David Kirn (CEO) in San Francisco and Dr. John Bell (CSO) from the Ottawa Health Research Institute/University of Ottawa. Jennerex is a clinical-stage biopharmaceutical company focused on the development and commercialization of first-in-class, breakthrough targeted oncolytic products for cancer. The company's lead product JX-594, currently in an international Phase 2 trial for primary liver cancer, demonstrated promising Phase 1 efficacy and safety results in patients with a diverse array of common large market cancers. Jennerex's products target, attack and eradicate cancers through a novel and potent oncolytic mechanism that is dependent on highly-specific replication of the
'/>"/>

SOURCE Jennerex, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Jennerex Publishes Clinical Trial Data With Lead Product JX-594 Demonstrating Efficacy Against Liver Cancer and Associated Hepatitis B Virus
2. Jennerex Publishes Promising Results from Cancer Clinical Trial of JX-594 in Lancet Oncology
3. Jennerex Presents Clinical Data From JX-594 Demonstrating Tumor Efficacy Against Advanced Liver Cancers
4. Regado Biosciences Completes Patient Enrollment for Phase IIa Study of REG1 Anticoagulation System
5. Boston Scientific Completes Clinical Trial Enrollment for Third-Generation Drug-Eluting Stent
6. Peregrine Pharmaceuticals Completes Patient Enrollment in First Stage of Its Second Bavituximab Phase II Breast Cancer Trial
7. VIA Pharmaceuticals Completes Patient Visits in Phase 2 Acute Coronary Syndrome (ACS) Trial
8. Anthera Completes Special Protocol Assessment With FDA and Receives EMEA Scientific Advice on Development Path Toward Varespladib Approval
9. Arpida Completes Enrolment in Phase II "Intravenous-to-Oral" Switch Trial With Oral Iclaprim
10. Merck Serono Completes Enrollment in the REFLEX Trial of Rebif(R) in Patients at Risk of Developing Multiple Sclerosis
11. CuraGen Completes Enrollment in Phase II Trial of CR011-vcMMAE in Metastatic Melanoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... , September 2, 2014 , ... patients, quality of life and treatment satisfaction [ ... ]        ... 2014, 02 September 2014, Barcelona, Spain ... the PREvention oF thromboembolic events-European Registry in Atrial Fibrillation ...
(Date:9/2/2014)... Utah , Sept. 2, 2014 /PRNewswire-iReach/ -- Ortho ... the Alpine™ Hip Stem, the latest addition to ... Hip Stem is intended for use in total ... - http://photos.prnewswire.com/prnh/20140830/141676 Alpine ... hip stem philosophy. ODEV,s engineers worked closely with ...
(Date:9/2/2014)... RALEIGH, N.C. and ,S-HERTOGENBOSCH, the ... Europe ( http://www.healthlinkeurope.com ) has expanded its North American ... 100% medical facility, providing warehousing, fulfillment and order to ... North America , utilizing our global ERP platform. ... since 1994 serving our customers in Europe ...
Breaking Medicine Technology:One Year Data from the PREFER in AF Registry Show Significant Changes in Atrial Fibrillation (AF) Management in Europe and Implementation of Clinical Guidelines 2One Year Data from the PREFER in AF Registry Show Significant Changes in Atrial Fibrillation (AF) Management in Europe and Implementation of Clinical Guidelines 3One Year Data from the PREFER in AF Registry Show Significant Changes in Atrial Fibrillation (AF) Management in Europe and Implementation of Clinical Guidelines 4One Year Data from the PREFER in AF Registry Show Significant Changes in Atrial Fibrillation (AF) Management in Europe and Implementation of Clinical Guidelines 5One Year Data from the PREFER in AF Registry Show Significant Changes in Atrial Fibrillation (AF) Management in Europe and Implementation of Clinical Guidelines 6One Year Data from the PREFER in AF Registry Show Significant Changes in Atrial Fibrillation (AF) Management in Europe and Implementation of Clinical Guidelines 7One Year Data from the PREFER in AF Registry Show Significant Changes in Atrial Fibrillation (AF) Management in Europe and Implementation of Clinical Guidelines 8Ortho Development Receives FDA Clearance for Alpine Hip Stem 2HealthLink Europe opens North American medical warehouse operation 2
... Inc. (NYSE: SMA ), a leading global ... surgical instruments, and sterilization cases and trays, announced today ... Olsen Medical. Olsen Medical is a privately-held, ... electrosurgical instruments and accessories. It manufactures a full line ...
... 2011 Pharmaceutics International, Inc. (Pii), a leading ... has successfully completed the first-ever US-based joint European ... (FDA) inspection.   "Our entire team ... the joint FDA/EMA inspection," said Tony Horton, vice ...
Cached Medicine Technology:Symmetry Medical Closes Olsen Medical Acquisition 2Pharmaceutics International, Inc. (Pii) Successfully Completes EMA and FDA Inspection 2
(Date:9/2/2014)... Recently, iFitDress.com, a famous online supplier ... released its range of 2014 seashell wedding dresses ... low prices. A large proportion of them are priced ... iFitDress.com are carefully made by the most skilled workers. ... party gowns, ivory satin wedding gowns, white halter wedding ...
(Date:9/2/2014)... September 03, 2014 Recently, Top ... hosting companies and announced that JustHost ( http://www.justhost.com/track/seohosts ... the webmasters. , “The hosting suppliers we recommend ... their competitors on hosting features, uptime and server ... 10 Best SEO Hosting says. “We believe that ...
(Date:9/2/2014)... Friendship Village of Schaumburg is proud to ... contemporary marketing presence and visually solidifies the relationship ... Senior Options,” said Stephen A. Yenchek, president and ... logo, we are making sure that our identity ... families.” , Friendship Village is a retirement community ...
(Date:9/2/2014)... The Wm. Jennings Bryan Dorn Veterans Affairs ... hall meeting for Veterans and their families on September 24. ... to provide Veterans with valuable healthcare and benefit information,” said ... provide a forum where we can gather important input directly ... fair will be held 4:45 p.m. to 5:45 p.m. in ...
(Date:9/2/2014)... followed by radiation therapy survived as long as ... large study conducted by researchers at the Stanford ... Institute of California. , The comprehensive analysis of ... the first to directly compare survival rates following ... (the removal of both breasts), unilateral mastectomy (the ...
Breaking Medicine News(10 mins):Health News:Discounted Seashell Wedding Dresses Currently Provided By iFitDress.com 2Health News:Friendship Village of Schaumburg In Illinois Announces New Logo 2Health News:Breast cancer patients with bilateral mastectomy don't have better survival rates 2Health News:Breast cancer patients with bilateral mastectomy don't have better survival rates 3Health News:Breast cancer patients with bilateral mastectomy don't have better survival rates 4
... Osteoporosis, wherein the density of the bone is lost and ... after they attain their menopause. This happens as a result ... the bone density. ,Dr. Sunil J. Wimalawansa, of the ... study using the animal model that Vitamin E may prevent ...
... women is on the rise. But the alarm bells are ... smokers with breast cancer face an increased risk of their ... nonsmokers ,"There is a relationship between smoking and ... MD, associate professor of medicine at the University of California ...
... is associated with loss of libido, low motivation and ... their menopause or whose ovaries had been removed surgically ... effective treatment in such sexual dysfunction, according to a ... American Urological Association in Anaheim, California. This report was ...
... the current New England Journal of Medicine that an experimental ... men suffering from hemophilia. This method shows signs of ... clotting protein they lack. None of the patients suffers ... ,The study was designed only to test the safety and ...
... be the latest mantra of Pfizer. The pharmaceutical giant ... 50 countries hardest hit by the AIDS virus. The decision ... South African Government winning a landmark case against pharmaceutical companies. ... antifungal drug Diflucan will be given free of cost to ...
... Azad Medical College, New Delhi has created history of ... from the American patent office for his technique in ... ,A few weeks ago the American patent office granted ... was able to regenerate organs like the uterus, urethra ...
Cached Medicine News:
The Freedom Clear catheter is a 100% latex-free, self-adhering, one piece catheter with an ultra-thin sheath for every day wear....
Freedom Clear® SS Sport Sheath is a 100% latex-free, self-adhering, one piece catheter with an ultra-thin sheath designed for everyday wear. Its brief sheath minimizes roll at the base of the p...
... clear, all-silicone Foley catheters eliminate patient ... Foley catheter designs. As an inert, ... creating a safe, dependable Foley catheter. ... all-silicone catheters will not leach chemicals ...
... stone manipulation and removal in ... strength permits the basket to ... than standard flat-wire designs. The ... one-handed operation. Supplied sterile in ...
Medicine Products: