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Japanese Fund Moves Quickly to Invest in Promising Technology Against Malaria, Tuberculosis And Chagas Disease
Date:11/7/2013

are the current gold-standard anti-malarial treatments that combine fast-acting artemisinin derivatives with a long-acting partner drug. The new drug candidate, DSM265, which kills the malaria parasite through inhibition of an essential enzyme, is a compound with a long duration of action that could potentially be part of a new treatment for malaria, with potential for being part of a single dose cure. The compound recently entered clinical phase I studies in healthy human volunteers. If the planned studies show that it works safely and effectively, DSM265 could undergo later-stage development as a new option in the treatment of malaria.

An additional award of approximately US$575,000 was granted to MMV in partnership with Takeda for development and its formulation of ELQ300, an anti-malarial compound that is in earlier stages of development. ELQ300 has the potential to be given once a month to treat and prevent malarial infections, which would make it an important tool in the control of malaria. However, some additional work related to its formulation is needed before it can be tested in patients.

The GHIT Fund will also invest in candidate products for tuberculosis and Chagas disease. For tuberculosis, a disease that causes an estimated 8.6 million new cases and kills about 1.3 million people annually, the Fund will invest US$720,000 for early work on a novel vaccine candidate against tuberculosis being co-developed by the National Institute of Biomedical Innovation, Japan's Create Vaccine Co., Ltd. and Aeras, an international non-profit biotech based in Washington, DC. The vaccine is the first to target the patient's mucous membranes to keep TB from making an entry into the lungs. In mice, the vaccine added protection to BCG, the current vaccine against tuberculosis. BCG was invented nearly 90 years ago and provides insufficient protection to teenagers and adults, the group with the highest TB bu
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SOURCE Global Health Innovative Technology Fund (GHIT Fund)
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