Navigation Links
Janssen Research & Development Submits Application to U.S. FDA for XARELTO® (rivaroxaban) to Reduce Secondary Cardiovascular Events in Patients with Acute Coronary Syndrome

places patients at an increased risk of thrombotic events. An increased rate of stroke was observed following XARELTO® discontinuation in clinical trials in atrial fibrillation patients. If anticoagulation with XARELTO® must be discontinued for a reason other than pathological bleeding, consider administering another anticoagulant.



Epidural or spinal hematomas have occurred in patients treated with XARELTO® who are receiving neuraxial anesthesia or undergoing spinal puncture. These hematomas may result in long-term or permanent paralysis. Consider these risks when scheduling patients for spinal procedures. Factors that can increase the risk of developing epidural or spinal hematomas in these patients include: 

  • Use of indwelling epidural catheters 
  • Concomitant use of other drugs that affect hemostasis, such as non-steroidal anti-inflammatory drugs (NSAIDs), platelet inhibitors, other anticoagulants, see Drug Interactions
  • A history of traumatic or repeated epidural or spinal punctures 
  • A history of spinal deformity or spinal surgery

Monitor patients frequently for signs and symptoms of neurological impairment. If neurological compromise is noted, urgent treatment is necessary.


Consider the benefits and risks before neuraxial intervention in patients anticoagulated or to be anticoagulated for thromboprophylaxis.


  • Active pathological bleeding
  • Severe hypersensitivity reaction to XARELTO®


  • Increased Risk of Stroke After Discontinuation in Nonvalv

SOURCE Janssen Research & Development, LLC
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10 11

Related medicine technology :

1. Record Breaking $327 Million Verdict Upheld in Janssen Case and Request for New Trial Denied
2. Dr. Paul Janssen Award for Biomedical Research Issues Call for Nominations
3. Pharmacyclics Forms Pact to Develop and Commercialize PCI-32765 for Hematologic Cancers with Janssen Biotech, Inc.
4. Janssen Pharmaceuticals, Inc. Launches Online Tools on
5. Janssen Pharmaceuticals, Inc. Announces Definitive Agreement to Divest Ortho Dermatologics Division
6. Dr. Napoleone Ferrara Wins 2011 Dr. Paul Janssen Award for Biomedical Research
7. Janssen Products, LP Modifies Prescribing Information for PROCRIT® (Epoetin alfa) in Chronic Kidney Disease
8. Ortho-McNeil-Janssen Pharmaceuticals, Inc. Voluntarily Recalls One Lot of RISPERDAL® Tablets and One Lot of Risperidone Tablets
9. Record Breaking $327 Million Verdict Announced in Janssen Case
10. MHPA Center for Best Practices Receives Sponsorship from Ortho-McNeil Janssen Pharmaceuticals, Inc. to Improve Medicaid Quality, Care Coordination for Serious Mental Illness
11. Lilly Makes an Irrevocable Offer to Acquire Janssen Animal Health
Post Your Comments:
(Date:2/27/2015)... 2015 Securities lawyers at Dunnam & ... Ltd. (NASDAQ: SLXP ) in connection with ... investors are encouraged to contact attorney Hamilton Lindley by ... focuses upon the shareholder value of the transaction. Under ... only $158.00 per share in cash. At least one ...
(Date:2/27/2015)... , February 27, 2015 Report ... study showing you trends, R&D progress, and predicted revenues ... heading? What are the commercial prospects for this market ... potential revenues and other trends to 2025, discussing data, ... lets you assess regenerative medicine : cell-based therapies ...
(Date:2/27/2015)...  Organovo Holdings, Inc. (NYSE MKT: ONVO) ("Organovo"), ... 3D bioprinting technology, announced today that Keith ... present live at on March 5th. ... for this Company update," said Mr. Murphy. "We ... of the exVive3D Liver, Bioprinted Human Tissue, commercialization ...
Breaking Medicine Technology:Translational Regenerative Medicine: Market Prospects 2015-2025 2Translational Regenerative Medicine: Market Prospects 2015-2025 3Translational Regenerative Medicine: Market Prospects 2015-2025 4Translational Regenerative Medicine: Market Prospects 2015-2025 5Translational Regenerative Medicine: Market Prospects 2015-2025 6Translational Regenerative Medicine: Market Prospects 2015-2025 7Translational Regenerative Medicine: Market Prospects 2015-2025 8Organovo Holdings, Inc. to Provide Corporate Update and Investor Presentation in a Live, Interactive Webcast on March 5th 2Organovo Holdings, Inc. to Provide Corporate Update and Investor Presentation in a Live, Interactive Webcast on March 5th 3Organovo Holdings, Inc. to Provide Corporate Update and Investor Presentation in a Live, Interactive Webcast on March 5th 4
(Date:2/27/2015)... 2015 Royal River Natural Foods, a locally-owned ... study that found adults who got the most magnesium were ... compared to those who got the least magnesium, with the ... The report is part of the March 2015 issue of ... Natural Foods publishes free each month for the Freeport community ...
(Date:2/27/2015)... Adding to its rich history ... Advertising & Marketing has added Sedation Systems of ... patented NITROUSEAL® N20 closed mask and breathing circuit ... , Sedation Systems, is dedicated ... level, though it focuses primarily on pediatric patients. ...
(Date:2/27/2015)... (PRWEB) February 27, 2015 FACE ... therapies, has announced a unique combination to take ... neck. Ultherapy Décolletage is a new treatment introduced ... noninvasive procedure specifically indicated to improve lines and ... for any person who suffers from the stubborn ...
(Date:2/27/2015)... 2015 The Nashville periodontist ... scholarship for rising freshmen undergraduate students. , The Advanced ... specializing in many periodontal procedures such as dental ... gum disease . In honor of their 25th anniversary, ... eligible rising freshmen undergraduate students. , Students interested ...
(Date:2/27/2015)... Ford, Pennsylvania (PRWEB) February 27, 2015 ... the Spring Breast Augmentation Special at his Chadds Ford, ... 13 through May 1, 2015, and will be priced ... to the latest silicone implants, it will include more ... price and $250 worth of free Dysport. , Space ...
Breaking Medicine News(10 mins):Health News:New Study Finds Magnesium May Slow Progress of Diabetes, Retailer Reports 2Health News:Benedict Advertising & Marketing Signs Sedation Systems 2Health News:Face Skincare Announces New Combination Therapy 2Health News:Nashville Periodontist Office AIOH Announces 2015 Scholarship 2Health News:Dr. Christopher Saunders Announces Spring Breast Augmentation Special at $3,950 2Health News:Dr. Christopher Saunders Announces Spring Breast Augmentation Special at $3,950 3
... nasal spray to quash allergy symptoms may work better ... an "as-needed'', rather than daily basis, the nasal spray ... sneezing and congestion more effectively than the antihistamine loratadine ... fights allergy symptoms by reducing the inflammation that occurs ...
... intravenous magnesium sulfate to standard emergency department migraine ... enhance the effectiveness of treatment.// Dr. Jill Corbo, ... Medicine in the Bronx, New York, note that ... in the treatment of migraine headache and that ...
... to bear an underweight child, but some women may ... susceptibility.// The finding could help medicine better determine the ... they were not recommending at this point that women ... ,"Our data demonstrate that a subgroup of pregnant ...
... that butterbur extract is an effective antihistamine without any ... an active biochemical agent,// otherwise it would not work ... react with other medications. ,It was used ... either butterbur extract tablets or the usually used non-sedating ...
... 40,000 more lives each year worldwide if more people at ... it, doctors said.// An analysis of nearly 300 clinical ... prevent blood clots confirmed that aspirin reduces heart attacks and ... people who could benefit from aspirin and anti-platelet therapy receive ...
... stones, which are often extremely painful to excrete, cost ... lost productivity. While the stones can sometimes be prevented ... the bladder frequently,// medication to reduce the excretion of ... increase cholesterol and can cause bloating and other uncomfortable ...
Cached Medicine News:
... I (cTnI) has been useful in the ... Departments (ED) with chest pain. 18-20 ... blood levels of sensitive and specific biomarkers, ... of creatine kinase (CK-MB), and myoglobin, are ...
... potent, naturally secreted estrogen and is the ... In the ovary, estradiol is produced from ... potent estrogen derived from androstenedione. Estrone and ... In men, small amounts of estradiol are ...
... Aio! 2nd generation cardiac troponin ... sensitive immunoassay providing quantitative results ... less than 18 minutes. The ... unique combination of antibodies that ...
... The VITROS ECi brings true automation ... immunodiagnostic testing. Highly sensitive assays for ... and bone metabolism testing are currently ... development. The VITROS ECi can simultaneously ...
Medicine Products: