Navigation Links
Janssen Products, LP Modifies Prescribing Information for PROCRIT® (Epoetin alfa) in Chronic Kidney Disease
Date:6/24/2011

itional benefit.  Use caution in patients with coexistent cardiovascular disease and stroke.  Patients with CKD and an insufficient hemoglobin response to ESA therapy may be at even greater risk for cardiovascular reactions and mortality than other patients.  A rate of hemoglobin rise of greater than 1 g/dL over 2 weeks may contribute to these risks.
  • In controlled clinical trials of patients with cancer, PROCRIT and other ESAs increased the risks for death and serious adverse cardiovascular reactions.  These adverse reactions included myocardial infarction and stroke.
  • In controlled clinical trials, ESAs increased the risk of death in patients undergoing coronary artery bypass graft surgery (CABG) and the risk of deep venous thrombosis (DVT) in patients undergoing orthopedic procedures.

  • Increased Mortality and/or Increased Risk of Tumor Progression or Recurrence in Patients With Cancer

    • ESAs resulted in decreased locoregional control/progression-free survival and/or overall survival.  These findings were observed in studies of patients with advanced head and neck cancer receiving radiation therapy, in patients receiving chemotherapy for metastatic breast cancer or lymphoid malignancy, and in patients with non-small cell lung cancer or various malignancies who were not receiving chemotherapy or radiotherapy.

    Hypertension

    • PROCRIT is contraindicated in patients with uncontrolled hypertension.  Following initiation and titration of PROCRIT, approximately 25% of patients on dialysis required initiation of or increases in antihypertensive therapy; hypertensive encephalopathy and seizures have been reported in patients with CKD receiving PROCRIT.  
    • Appropriately control hypertension prior to initiation of and during treatment with PROCRIT.  Reduce or withhold PROCRIT if
      '/>"/>

    SOURCE Janssen Products, LP
    Copyright©2010 PR Newswire.
    All rights reserved

    Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14

    Related medicine technology :

    1. Ortho-McNeil-Janssen Pharmaceuticals, Inc. Voluntarily Recalls One Lot of RISPERDAL® Tablets and One Lot of Risperidone Tablets
    2. Record Breaking $327 Million Verdict Announced in Janssen Case
    3. MHPA Center for Best Practices Receives Sponsorship from Ortho-McNeil Janssen Pharmaceuticals, Inc. to Improve Medicaid Quality, Care Coordination for Serious Mental Illness
    4. Lilly Makes an Irrevocable Offer to Acquire Janssen Animal Health
    5. Dr. Paul Janssen Award for Biomedical Research Issues Call for Nominations
    6. Ortho-McNeil-Janssen Pharmaceuticals, Inc. Announces Oncology Research Collaboration Agreement with the Koch Institute for Integrative Cancer Research at MIT
    7. The Pittsburgh Life Sciences Greenhouse Congratulates Diamyd Medical on Its Agreement with Ortho-McNeil-Janssen Pharmaceuticals to Develop Diabetes Therapy
    8. Ortho-McNeil-Janssen Pharmaceuticals, Inc. Resolves Investigation of Past TOPAMAX(R) Marketing and Promotional Activities
    9. Ortho-McNeil-Janssen Pharmaceuticals, Inc. Agrees to $75 Million Settlement for Topamax(R) False Claims Lawsuit
    10. WuXi PharmaTech Enters into Collaboration with J&JPRD, a division of Janssen Pharmaceutica for Preclinical Services and Training
    11. Nominations Open for the 2010 Dr. Paul Janssen Award for Biomedical Research
    Post Your Comments:
    *Name:
    *Comment:
    *Email:
    (Date:7/29/2015)... ALBANY, New York , July 29, 2015 /PRNewswire/ ... published by Transparency Market Research " Active Pharmaceutical Ingredients ... Trends and Forecast 2014 - 2020 " the global ... billion in 2013 and is anticipated to reach USD ... 6.5% during the forecast period from 2014 to 2020. ...
    (Date:7/29/2015)... 24, 2015 Research and Markets ( ... "Global Wound Care Markets (Twelve Country Analysis: ... Canada, China, India, Brazil, Australia, South Korea)" ... report provides a competitive market summary. The wound ... product offerings and product maturity. Several of the ...
    (Date:7/29/2015)... YORK , July 29, 2015 /PRNewswire/ ... a new research report "Global Industry Insight: ... to 2020" with market overview, trends, DRO analysis, ... analysis, recent developments, competitive scenario and top ... http://photos.prnewswire.com/prnh/20150727/756778 ) Microfluidic devices  ...
    Breaking Medicine Technology:Active Pharmaceutical Ingredients Market Expected to Reach USD 185.9 Billion Globally in 2020: Transparency Market Research 2Active Pharmaceutical Ingredients Market Expected to Reach USD 185.9 Billion Globally in 2020: Transparency Market Research 3Active Pharmaceutical Ingredients Market Expected to Reach USD 185.9 Billion Globally in 2020: Transparency Market Research 4Active Pharmaceutical Ingredients Market Expected to Reach USD 185.9 Billion Globally in 2020: Transparency Market Research 5Global Wound Care Markets 2015 2Global Microfluidic Devices Market (Size of $1,886 Million in 2014) to Witness a CAGR of 23% During 2015 - 2020 2Global Microfluidic Devices Market (Size of $1,886 Million in 2014) to Witness a CAGR of 23% During 2015 - 2020 3Global Microfluidic Devices Market (Size of $1,886 Million in 2014) to Witness a CAGR of 23% During 2015 - 2020 4Global Microfluidic Devices Market (Size of $1,886 Million in 2014) to Witness a CAGR of 23% During 2015 - 2020 5
    ... Feb. 9, 2012 Former employees of Omnicare, Inc., ... care for seniors, claim that they have been unlawfully underpaid ... filed January 26th in U.S. District Court for the ... et al ., Case Number 8:12-cv-00169) seeks relief under ...
    ... 2012   Resource Anesthesia , an anesthesia contract management ... locations to its management portfolio. Phil Haynie, ... that the company has added the following facilities to ... of Washington -- Hadley, 4601 Martin Luther King Jr. ...
    Cached Medicine Technology:A Full Day's Pay for a Full Day's Work 2Resource Anesthesia Adds Locations Under Management, Announces Addition of HealthStream LearningCenter® 2
    (Date:7/29/2015)... ... ... " Core Organizer ” was featured on NewsWatch as part of its ... market for iOS, Android, and Windows. Joe Toohey, the host of AppWatch and technology ... anyone get organized. , Wouldn’t it be great if everyone could be a little ...
    (Date:7/29/2015)... , ... July 29, 2015 , ... ... autism. Parents, educators and service providers of children living with autism will converge ... serve the growing demographic. , The National Autism Conference will be held ...
    (Date:7/29/2015)... ... 2015 , ... According to The Spirits Business on July 16th, ... for stimulating and perpetuating alcohol use disorders. Humans have the same gene, which is ... academy of Sciences, and has given researchers inklings to explore Rsu1 in humans to ...
    (Date:7/29/2015)... ... July 29, 2015 , ... With a new ... up with Stillwaters Cancer Support Services and announced a new charity campaign to ... family counseling, support groups, workshops and educational programs at no charge. Scott ...
    (Date:7/29/2015)... ... July 29, 2015 , ... Wedding season is in full swing, which means bridal beauty ... of looking good on the big day. Every bride wants to look and feel beautiful, ... , According to a recent study by the American Academy of ...
    Breaking Medicine News(10 mins):Health News:Get More Organized with the Core Organizer App 2Health News:Penn State Conference to Address Instruction, Success for Children with Autism 2Health News:Study Reveals Potential for Gene Manipulation to Stop Alcohol Addiction 2Health News:Study Reveals Potential for Gene Manipulation to Stop Alcohol Addiction 3Health News:Scott Campbell Agency and Nonprofit Stillwaters Cancer Support Services Initiate New Charity Campaign in Waukesha, WI to Provide Help for People Touched by Cancer 2Health News:Scott Campbell Agency and Nonprofit Stillwaters Cancer Support Services Initiate New Charity Campaign in Waukesha, WI to Provide Help for People Touched by Cancer 3Health News:Say I Do To Surgery: Bridal Beauty On The Rise According to New Survey 2Health News:Say I Do To Surgery: Bridal Beauty On The Rise According to New Survey 3
    ... cell therapies hold enormous potential to address some of ... However, the inability to target cells to tissues of ... To address this hurdle, researchers at Brigham and Women,s ... incorporate homing receptors onto the surface of cells. This ...
    ... , THURSDAY, Oct. 27 (HealthDay News) -- A ... of the arteries -- or atherosclerosis -- which can lead ... young men and 84 young women, aged 18 to 35, ... diabetes, smoking, high blood pressure, high blood cholesterol or family ...
    ... , THURSDAY, Oct. 27 (HealthDay News) -- Americans ... U.S. health officials said Thursday. Someone in the world ... Americans die of stroke every year. That number is about ... according to the U.S. Centers for Disease Control and Prevention. ...
    ... received a two-year, $452,218.00 grant from the national ... and Post-Breast Cancer Lymphedema." Post-breast cancer lymphedema ... distressing symptoms, is caused by injuries to the ... cancer treatment lengthen survival, LE has emerged as ...
    ... Researchers have identified a safer, more cost effective way ... an abdominal aortic aneurysm a common, often asymptomatic ... deadly. A new study done by investigators at ... invasive spinal, epidural and local/monitored anesthesia care (MAC) is ...
    ... sometimes referred to as a "mini stroke", were much less ... if their care was co-ordinated by a special hospital team. ... the November issue of the European Journal of Neurology ... Aarhus University Hospital in Denmark studied 306 patients admitted to ...
    Cached Medicine News:Health News:Programming cells to home to specific tissues may enable more effective cell-based therapies 2Health News:Many Young Adults Unaware They're Developing Heart Disease 2Health News:U.S. Health Officials Urge Lifestyle Changes to Cut Stroke Risk 2Health News:NYU College of Nursing receives 450 thousand dollar NIH grant to research post-breast cancer lymphedema 2Health News:Less invasive anesthetic methods better for endovascular aneurysm repair 2Health News:Less invasive anesthetic methods better for endovascular aneurysm repair 3Health News:Hospital team significantly reduced risk of further vascular events after 'mini strokes' 2Health News:Hospital team significantly reduced risk of further vascular events after 'mini strokes' 3
    ... These dual pressure sensor ... sampling/slow-speed injection, slow-speed injection/guide wire, ... model SPC-784A for high-speed injection ... side openings and an open-end ...
    ... Mikro-Tip Pressure Catheters; Millar manufactures and ... sensor catheters for simultaneous high fidelity ... for measuring pressure gradients across a ... vascular stenosis. The catheters are made ...
    ... The XTD Thrombectomy catheter is a mechanical ... thrombus from occluded hemodialysis access grafts. The ... consists of a rotatable, spiral shaft which ... a flexible, distal curved tip. In use, ...
    ... These catheters are indicated ... soft emboli and thrombi from ... These catheters may also be ... blood vessels, infusion of fluids, ...
    Medicine Products: