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Janssen Launches EXPLORER, Global Cardiovascular Research Program, Beginning with Five New Studies in Patients with Unmet Medical Needs
Date:3/8/2013

en and its development partner, Bayer HealthCare, will enroll patients into five global clinical trials:

  • COMMANDER-HF will evaluate XARELTO® in patients with chronic heart failure and significant coronary artery disease who are receiving standard care. The study will include 5,000 patients in 12 countries.
  • COMPASS will evaluate XARELTO® in patients with coronary artery disease or peripheral artery disease. This study includes 20,000 patients across 25 countries and will be conducted in collaboration with the Population Health Research Institute (PHRI) at McMaster University in Hamilton, Canada.
  • PIONEER AF-PCI will evaluate XARELTO® in 2,100 patients who have non-valvular atrial fibrillation and are undergoing percutaneous coronary intervention (PCI) with stent placement. The trial will assess XARELTO® in combination with dual antiplatelet therapy and when aspirin is not used.
  • X-VeRT will evaluate patients with atrial fibrillation scheduled for cardioversion – a medical procedure to convert abnormally fast heart rate to a normal rhythm, using electricity or antiarrhythmic medications. The study includes 1,500 patients across 17 countries and will compare XARELTO® to dose-adjusted vitamin K antagonist.
  • VENTURE-AF will evaluate the use of XARELTO® in patients with non-valvular atrial fibrillation undergoing catheter ablation, a procedure that uses energy delivered through catheters to eliminate the abnormal tissue that is causing the arrhythmia. The study will include up to 250 patients in four countries.

In addition, as part of our ongoing commitment to expanding therapeutic choices for health care professionals, Janssen recently announced<
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