Navigation Links
Janssen Announces Collaboration with Vertex on Phase 2 Study to Investigate an All-Oral Regimen of Simeprevir (TMC435) and VX-135 for Treatment of Hepatitis C
Date:11/1/2012

TITUSVILLE, N.J., Nov. 1, 2012 /PRNewswire/ -- Janssen Pharmaceuticals, Inc. today announced that it has entered into a non-exclusive collaboration with Vertex Pharmaceuticals Incorporated to evaluate in a Phase 2 study the safety and efficacy of an all-oral regimen for the treatment of hepatitis C (HCV). The regimen will include Janssen's investigational protease inhibitor simeprevir (TMC435) and Vertex's investigational nucleotide analogue HCV polymerase inhibitor VX-135. As a first step, Janssen will conduct a drug-drug interaction (DDI) study with simeprevir and VX-135. The DDI study will support the initiation of the Phase 2 study in early 2013 pending discussions with regulatory authorities.

The goal of the Phase 2 study will be to evaluate the safety, tolerability and viral cure rates of a 12-week regimen of simeprevir and VX-135, administered with and without ribavirin, in treatment-naive patients who have chronic non-cirrhotic genotype 1 HCV. The companies will jointly fund development costs associated with the collaboration. There are no up-front or milestone payments associated with the agreement.

Simeprevir is an investigational NS3/4A protease inhibitor currently in Phase 3 trials, developed in collaboration with and licensed from Medivir AB. VX-135 is an investigational uridine nucleotide analogue pro-drug designed to inhibit the replication of HCV by acting on the NS5B polymerase. 

"There is a significant unmet need for all-oral treatment regimens for people living with hepatitis C," said Wim Parys, Global Head of Infectious Diseases at Janssen. "Janssen's collaboration with Vertex underscores our commitment to better understand the potential utility of simeprevir in a number of different interferon-free treatment combinations and HCV patient populations."

About Simeprevir
Simeprevir (TMC435) is an NS3/4A protease inhibitor jointly developed by Janssen and Medivir AB to treat chronic HCV infection. Simepr
'/>"/>

SOURCE Janssen Pharmaceuticals, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. West Announces Agreement with Janssen Biotech to Develop and Commercialize a New Self-injection Technology
2. Janssen Biotech Announces Global License and Development Agreement for Investigational Anti-Cancer Agent Daratumumab
3. Janssen Announces Initiation Of Phase 3 Development Program For Sirukumab In Rheumatoid Arthritis
4. Janssen Research & Development Submits New Drug Application to U.S. FDA for Canagliflozin to Treat Patients with Type 2 Diabetes
5. Janssen Research & Development Submits XARELTO® (rivaroxaban) to U.S. FDA for the Treatment and Prevention of Recurrent Venous Thromboembolism
6. Anthera Announces the Phase 2b PEARL-SC Data Has Been Accepted as a Late Breaking Poster Presentation at the ACR/ARHP 2012 Annual Scientific Meeting
7. Watson Announces Global Generics Management Team
8. Watson Announces New Name -- Actavis -- for Global Operations
9. BioMed Realty Announces 93,000 Square Foot Lease Expansion And Extension With Ironwood Pharmaceuticals At 301 Binney Street
10. Abaxis Announces Exclusive Distribution Agreement with Abbott
11. Thesan Pharmaceuticals Announces Series A Funding Co-Led By Novo Ventures And Novartis Venture Funds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... 1, 2014 Arena Pharmaceuticals, Inc. (NASDAQ: ... update and reported financial results for the second ... "We have continued to see encouraging advancements in ... quarter-over-quarter increase in estimated total prescriptions and estimated ... said Jack Lief, Arena,s President and Chief Executive ...
(Date:7/31/2014)... 2014 Cipla Europe ... bekannt, vor kurzem für OneDose ReadyfusOR™ von ... chirurgischen Eingriffen eine kommerzielle Zusammenarbeit begonnen zu ... und weiterer europäischer Länder abdeckt. Cipla plant, ... gefüllte OneDose ReadyfusOR später in diesem Jahr ...
(Date:7/31/2014)... SAN DIEGO , July 31, 2014  Sorrento Therapeutics, ... death of Mr. Amar Singh , Chief Business Officer ... of apparent natural causes on July 30. "Sorrento ... dear friend and colleague. Our immediate thoughts go to Amar,s ... President and Chief Executive Officer. Mr. Singh ...
Breaking Medicine Technology:Arena Pharmaceuticals Provides Corporate Update and Reports Second Quarter 2014 Financial Results 2Arena Pharmaceuticals Provides Corporate Update and Reports Second Quarter 2014 Financial Results 3Arena Pharmaceuticals Provides Corporate Update and Reports Second Quarter 2014 Financial Results 4Arena Pharmaceuticals Provides Corporate Update and Reports Second Quarter 2014 Financial Results 5Arena Pharmaceuticals Provides Corporate Update and Reports Second Quarter 2014 Financial Results 6Arena Pharmaceuticals Provides Corporate Update and Reports Second Quarter 2014 Financial Results 7Arena Pharmaceuticals Provides Corporate Update and Reports Second Quarter 2014 Financial Results 8Arena Pharmaceuticals Provides Corporate Update and Reports Second Quarter 2014 Financial Results 9Arena Pharmaceuticals Provides Corporate Update and Reports Second Quarter 2014 Financial Results 10Arena Pharmaceuticals Provides Corporate Update and Reports Second Quarter 2014 Financial Results 11Cipla und BioQuiddity geben EU-Geschäftspartnerschaft für OneDose-ReadyfusOR zur Schmerzbehandlung nach chirurgischen Eingriffen bekannt 2Cipla und BioQuiddity geben EU-Geschäftspartnerschaft für OneDose-ReadyfusOR zur Schmerzbehandlung nach chirurgischen Eingriffen bekannt 3Sorrento Announces the Unexpected Death of its Chief Business Officer 2
... Reportlinker.com announces that a new market research ... Insulin- Western Europe ... package contains 14 insulin market analyses from ... Denmark, Finland, France, Germany, Ireland, Italy, the ...
... Calif., July 31, 2011 Accuray Incorporated ... radiation oncology company, announced today that it will showcase ... TomoTherapy® Radiation Therapy Treatment System in the ... Association of Physicists in Medicine (AAPM)/Canadian Organization of Medical ...
Cached Medicine Technology:Insulin- Western Europe 2Accuray Symposium Puts Spotlight on Quality Assurance in Radiation Oncology at Joint AAPM/COMP Meeting 2Accuray Symposium Puts Spotlight on Quality Assurance in Radiation Oncology at Joint AAPM/COMP Meeting 3Accuray Symposium Puts Spotlight on Quality Assurance in Radiation Oncology at Joint AAPM/COMP Meeting 4
(Date:8/1/2014)... Hawley, PA (PRWEB) August 01, 2014 Hot ... in the destination spa category of the World’s Best ... kicks off a month-long celebration of National Relaxation Day (technically ... together a series of MAJOR experts to help guests celebrate ... how important it is for health and wellness to carve ...
(Date:8/1/2014)... 1, 2014 (HealthDay News) -- Patients with the progressive, ... (COPD) have a new weapon to battle the disease, ... The agency approved a new treatment, an inhaled ... leading killer of Americans. COPD, which is often linked ... bronchitis and emphysema. Patients with COPD may ...
(Date:8/1/2014)... According to new market research report ... America, Europe, & ROW), by Vehicle Type (Passenger ... & Diesel), by After-Treatment Device (DPF, DOC, SCR, ... to 2019", defines and segments the global automotive ... countries in all the regions, and estimates their ...
(Date:8/1/2014)... Over the past five years, ... technologies that have enabled cosmetic dentists to provide ... Moreover, the burgeoning elderly population has stimulated demand ... Due to long-term use of medications, which may ... dental fillings, veneers and implants. As more elderly ...
(Date:8/1/2014)... Albany, NY (PRWEB) August 01, 2014 ... Surgical Generators Market Outlook to 2020", provides ... Surgical Generators market. The report provides value, ... units) and average prices (in US dollars) ... Electrocautery Generators, Ultrasonic Generators and Argon Plasma ...
Breaking Medicine News(10 mins):Health News:The Lodge at Woodloch Kicks Off National Relaxation Day with a Month Long Celebration 2Health News:The Lodge at Woodloch Kicks Off National Relaxation Day with a Month Long Celebration 3Health News:The Lodge at Woodloch Kicks Off National Relaxation Day with a Month Long Celebration 4Health News:FDA Approves New Treatment for People With COPD 2Health News:Automotive Exhaust Systems Market Will Be $33,379.7 Million by 2019 – New Report by MarketsandMarkets 2Health News:Automotive Exhaust Systems Market Will Be $33,379.7 Million by 2019 – New Report by MarketsandMarkets 3Health News:Automotive Exhaust Systems Market Will Be $33,379.7 Million by 2019 – New Report by MarketsandMarkets 4Health News:Cosmetic Dentists in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Cosmetic Dentists in the US Industry Market Research Report from IBISWorld Has Been Updated 3Health News:United Kingdom Surgical Generators Market Size, Share, Analysis, Trends and Forecasts 2020 2Health News:United Kingdom Surgical Generators Market Size, Share, Analysis, Trends and Forecasts 2020 3
... women more likely to have infants with certain birth defects, ... Overweight and obese women are more likely to give birth ... , U.S. Centers for Disease Control and Prevention researchers analyzed ... infants without heart defects whose mothers took part in the ...
... Education in the Round presentations available through live Webcasts ... The American Dental Association,s (ADA) interactive Education in the ... Session will reach beyond the convention center to thousands ... , The ADA and the American Dental Education ...
... WASHINGTON, Oct. 1 Mental Illness Awareness Week (MIAW) is Oct. ... National Alliance on Mental Illness (NAMI) is calling attention ... the Edge: Facing Mental Illness ." , Observed annually the ... to raise public awareness of serious mental illnesses such as major ...
... Study finds vaccination rates lag behind recommended levels , THURSDAY, ... stress the need to vaccinate children against seasonal flu, as ... seasonal flu is recommended for children 6 months to 18 ... Prevention,s Committee for Immunization Practices. , A report in the ...
... , Baucus health care reform bill recognizes ... , DERBY, Conn., Oct. 1 As the ... U.S. hospitals, VA Medical Centers and health care organizations ... spotlight patient-centered approaches to health care by commemorating the ...
... Nurses Association (WSNA), representing more than 16,000 registered nurses in ... MultiCare Health System for unilaterally implementing a mandatory vaccination policy. ... vaccination or to wear face masks as a condition of ... do not comply with the policy. The lawsuit seeks an ...
Cached Medicine News:Health News:Pre-Pregnancy Weight Linked to Babies' Heart Problems 2Health News:Dental Students, Faculty Gain Live Remote Access to ADA Annual Session Courses 2Health News:Dental Students, Faculty Gain Live Remote Access to ADA Annual Session Courses 3Health News:Mental Illness Awareness Week: What You Should Know, Including PBS Broadcasts, Oct. 4-10 2Health News:Children Need Seasonal Flu Vaccine, Experts Say 2Health News:Health Care Leaders Focus on Patient-Centered Care 2Health News:Health Care Leaders Focus on Patient-Centered Care 3Health News:Washington State Nurses Association Seeks Injunction in Federal Court to Block Mandatory Vaccination Policy by MultiCare Health System 2
... The F 250 is a portable system ... and temperature measurements. Temperature compensated pH results ... temperature probe (ATC) or a 3-in-1 electrode. ... three-point calibration with Auto-Find automatic buffer recognition ...
... highly accurate portable, waterproof system for pH, mV ... pH results can be obtained when used with ... • This GLP/GMP compliant system includes an RS-232 ... computer. Up to 100 data sets can be ...
... shelves. Over-sized compressor. Triple pane thermal ... Self-Contained System No plumbing required. Equipped ... Year Warranty on Parts & Labor and an ... Also available as a chromatography unit which includes ...
... controls for Digital Thermostat and Digital Display. ... , Interiorwhite anodized aluminum with 300 ... refrigeration (134A). , Temperature range 0C ... doors. , Foamed-in-place polyurethane high density ...
Medicine Products: