Navigation Links
JDRF and Lilly Partner to Fund Research to Identify Beta Cell Biomarkers
Date:11/14/2007

- $3 Million Grant Over Three Years from Lilly Foundation Could 'Fill a

Major Gap' in Diabetes Science -

NEW YORK, Nov. 14 /PRNewswire-FirstCall/ -- The Juvenile Diabetes Research Foundation and Eli Lilly and Company announced today that they are joining together to create a $3 million research effort to accelerate the pace of research into drugs and therapies to cure diabetes and its complications by developing biomarkers -- indicators that can measure the progress of disease and the effectiveness of therapeutics.

The project -- called the JDRF-Lilly Innovative and Academic Research and Development Grants in Diabetes Biomarkers -- will be funded by a $3 million grant from the Lilly Foundation to JDRF over three years.

JDRF is one of the world's largest charitable funder of type 1 diabetes research; over the last year, JDRF has funded more than $137 million in research to cure and develop therapeutics for type 1 diabetes and its complications. Lilly is a global leader in diabetes science and treatment, dating back to the development of the world's first commercially-available insulin in the 1920s, and continues to pioneer research to develop innovative medicines to address the unmet needs of people with diabetes.

The new JDRF-Lilly project will support cutting-edge research on biomarkers for pancreatic beta cell mass and function.

Biomarkers are natural features (lab values, images, or clinical features) whose detection indicates the presence of a particular disease state, or correlates with the risk or progression of a disease; for example, elevated prostate specific antigen is a molecular biomarker for prostate cancer. Two of the best-known biomarkers are cholesterol and blood pressure levels, which denote key information about cardiovascular health. In evaluating potential therapeutics, biomarkers can also serve as "surrogate endpoints" for evaluating the clinical benefit of a treatment.

"In general, the development of a range of biomarkers for both diabetes itself and its various complications would fill a major gap in science leading to a cure," said Arnold W. Donald, President and Chief Executive Officer of JDRF. "As the field of diabetes research moves from purely discovery research to the development of therapeutic cures and treatments, biomarkers will play a key role in increasing the pace of progress, and providing real benefits to people with diabetes. Lilly's grant to support beta cell mass and function research will play an important role in these efforts."

According to Dr. Paul Burn, Senior Vice President, Research, at JDRF, there are few current biomarkers for type 1 diabetes research and treatment. Biomarkers would be a powerful research tool in indicating the onset, status, and stage of diabetes; in predicting and monitoring a patient's clinical response to treatments developed as part of research funded by JDRF, Lilly, and others; and in accelerating the development of therapeutics by enabling researchers to rapidly assess the clinical outcomes of promising drug candidates.

"Biomarkers and the comprehensive information they can provide researchers are imperative to the progress of diabetes research," Dr. Burn said. "This project can rapidly advance the pace of scientific discovery and therapeutic developments for type 1 diabetes patients along multiple research pathways to finding a cure. Lilly is making a tremendous contribution to science that could, in turn, significantly improve the lives and outlooks of millions."

"Lilly's highest mission is to improve the lives of the people we serve -- and there is no group of patients with whom we have a longer and deeper relationship than people with diabetes," said Dr. John C. Lechleiter, Lilly's President and Chief Operating Officer. "Until there's a cure for diabetes, it's imperative that we continue searching for ways to improve treatment and solutions for managing this condition and its devastating complications. This research by JDRF could provide breakthroughs that would move the treatment of diabetes forward in new and exciting directions -- and maybe one day lead to a cure, the ultimate goal of diabetes research."

Grants by the JDRF-Lilly project will be available to both academic and commercial investigators. Innovative grant proposals will be evaluated through JDRF's grant review process, which includes both peer scientific review and lay review committees. For Academic Research and Development grants, JDRF will look to proactively match academic researchers with specific scientific targets. Currently, JDRF reviews thousands of research proposals annually, and funds more than 700 discovery and development projects.

About Eli Lilly and Company

Lilly, a leading innovation-driven corporation, is developing a growing portfolio of first-in-class and best-in-class pharmaceutical products by applying the latest research from its own worldwide laboratories and from collaborations with eminent scientific organizations. Headquartered in Indianapolis, Ind., Lilly provides answers - through medicines and information -- for some of the world's most urgent medical needs. Additional information about Lilly is available at http://www.lilly.com.

About Lilly Diabetes

Through a long-standing commitment to diabetes care, Lilly provides patients with breakthrough treatments that enable them to live longer, healthier and fuller lives. Since 1923, Lilly has been the industry leader in pioneering therapies to help healthcare professionals improve the lives of people with diabetes, and research continues on innovative medicines to address the unmet needs of patients.

About JDRF

JDRF was founded in 1970 by the parents of children with type 1 diabetes -- a disease that strikes children, adolescents, and adults suddenly, makes them insulin dependent for life, and carries the constant threat of devastating complications. Since inception, JDRF has provided more than $1.16 billion to diabetes research worldwide. More than 85 percent of JDRF's expenditures directly support research and research-related education. JDRF's mission is constant: to find a cure for diabetes and its complications through the support of research. For more information please visit http://www.jdrf.org.

O-LLY

(Logo: http://www.newscom.com/cgi-bin/prnh/20031219/LLYLOGO )

(Logo: http://www.newscom.com/cgi-bin/prnh/20071114/CLW148LOGO )


'/>"/>
SOURCE Eli Lilly and Company
Copyright©2007 PR Newswire.
All rights reserved

Related medicine technology :

1. FDA Approves Lillys Osteoporosis Drug EVISTA(R) (raloxifene HCl) to Reduce The Risk of Invasive Breast Cancer in Two Populations of Postmenopausal Women
2. Lilly Files for European Approval of ALIMTA(R) (pemetrexed for injection) for First-Line Treatment of Non-Small Cell Lung Cancer
3. Lilly and Glenmark Pharmaceuticals Announce License Agreement
4. Lilly Receives NCQA Design Certification for Depression Care Management Program
5. Harvard Medical School-Partners HealthCare Center for Genetics and Genomics Successfully Completes Evaluation of AutoGenomics 2C9-VKORC1 Panel to Assess Warfarin Sensitivity
6. Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor
7. BioMarin Partner AnGes MG, Inc. Submits BLA to Japanese Ministry of Health
8. Harvard Medical School-Partners HealthCare Center for Genetics and Genomics Successfully Completes Evaluation of AutoGenomics 2C9-VKORC1 Panel to Assess Warfarin Sensitivity
9. HistoRx and Radiation Therapy Oncology Group Initiate Brain Tumor Biomarker Research Partnership
10. The Leukemia & Lymphoma Society and Cleveland Clinic Taussig Cancer Institute Announce Groundbreaking Partnership to Accelerate Drug Approvals
11. PDHI Launches ConXus Rewards, Announces Partnership With Hallmark Insights to Support Incentive-Driven Wellness Programs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/25/2017)... 25, 2017  EpiVax, Inc., a leader in ... immune-engineering today announced the launch of EpiVax Oncology ... personalized therapeutic cancer vaccines. EpiVax has provided $500,000 ... to enabling technologies to the new precision immunotherapy ... EpiVax Oncology as Chief Executive Officer. Gad brings ...
(Date:9/19/2017)... 19, 2017   ZirMed Inc ., a recognized leader ... that it has been ranked #1 by its users for ... Rankings 2017 User Survey. ZirMed was recognized as the top-ranked ... and medical centers over 200 beds and holds one of ... user survey history. ...
(Date:9/12/2017)... MOUNTAIN LAKES, N.J. , Sept. 12, 2017  Consumer reviews ... Embrace Hearing as the number one company for hearing ... Oticon™, ReSound™ and fifteen other brands. ... Embrace Hearing Named #1 by Consumers For Hearing Aids ... Embrace Hearing is an online store that ...
Breaking Medicine Technology:
(Date:10/13/2017)... ... October 13, 2017 , ... Southern ... and Jennifer Huggins, PharmD ’17, along with clinical associate professor Janice Frueh, ... cardiovascular diseases during the 15th Annual Women’s Health Conference. The SIU School ...
(Date:10/13/2017)... Shelton, CT (PRWEB) , ... October 13, 2017 , ... ... and long-term care services, staged a mock evacuation of the facility as part of ... Department, Shelton Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well ...
(Date:10/13/2017)... ... 2017 , ... The Visiting Nurse Association (VNA) of Somerset Hills is proud ... and unique items from across the nation, this holiday-themed event will raise funds and ... the VNA. The boutique will be open Saturday, November 4 (10:00 a.m. – ...
(Date:10/13/2017)... NJ (PRWEB) , ... October 13, 2017 , ... Global ... at scenic Alexandria Park in Milford, NJ. This free event, sponsored by Global ... physical activity. The fun run is geared towards children of all ages; it ...
(Date:10/13/2017)... ... 2017 , ... Talented host, actor Rob Lowe, is introducing ... new episode of "Success Files," which is an award-winning educational program broadcasted on ... subject in-depth with passion and integrity. , Sciatica occurs when the sciatic nerve ...
Breaking Medicine News(10 mins):