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JDRF and Amylin Partner to Investigate Co-Formulating Two Hormones for Treatment of Type 1 Diabetes
Date:5/10/2011

type 1 diabetes. JDRF and Amylin are also currently collaborating on a proof-of-concept study at the UT Southwestern Medical Center to investigate the effects of metreleptin, an analog of the human hormone leptin, in patients with type 1 diabetes to determine whether it can help to decrease insulin requirements and better control glucose levels. To date, JDRF has funded 39 partnerships with 32 companies and committed approximately $73 million as part of its IDDP program.

About SYMLIN

Taken at mealtime, SYMLIN is the first and only amylin mimetic (or imitator of amylin) for use in patients with diabetes treated with mealtime insulin. In patients with type 2 diabetes who use insulin, and in patients with type 1 diabetes, beta cells in the pancreas that make both insulin and amylin are either damaged or destroyed, resulting in reduced secretion of both insulin and amylin after meals. Amylin deficiency can make it harder to control glucose levels after meals; therefore, using SYMLIN helps to make glucose control more attainable.

Healthcare professionals and patients with diabetes may obtain more information, including the complete Prescribing Information and the Medication Guide, at https://www.symlin.com/.

Important Safety Information for SYMLIN

SYMLIN is not intended for all patients with diabetes. SYMLIN is used with insulin and has been associated with an increased risk of insulin-induced severe hypoglycemia, particularly in patients with type 1 diabetes. When severe hypoglycemia associated with SYMLIN use occurs, it is seen within three hours following a SYMLIN injection. If severe hypoglycemia occurs while operating a motor vehicle, heavy machinery, or while engaging in other high-risk activities, serious injuries may occur. Appropriate patient selection, careful patient instruction, and insulin dose adjustments are critical elements for reducing this risk.

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SOURCE Amylin Pharmaceuticals, Inc.; Juvenile Diabetes Research Foundation
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