Navigation Links
Isis to Receive Up to $14 Million from Pfizer for Its Acquisition of Excaliard Pharmaceuticals
Date:11/22/2011

Phase 2, creating a strong clinical data package for this potentially breakthrough therapy.  Pfizer will provide additional drug development expertise and experience to support the continued advancement of EXC 001.  The market opportunity to treat disfiguring scars is very large, and we are pleased to have created an opportunity to participate in it through EXC 001 and Excaliard."

"CTGF has been an interesting target for fibrosis for years, and now we have the clinical data that Excaliard generated with EXC 001, which shows the importance of CTGF for the treatment of fibrotic disorders," said Brett Monia, Ph.D., Vice President, Drug Discovery and Corporate Development at Isis.  "We have been successfully pursuing systemic applications for CTGF, which differs from the local applications pursued by Excaliard, to treat a range of fibrotic diseases and look forward to advancing our program toward clinical development."

Isis and Excaliard entered into a collaboration in 2007 to discover and develop antisense drugs for the local treatment of fibrotic diseases, including scarring.  Excaliard is a private company funded by Rivervest Venture Partners, Alta Partners, Proquest Investments and Isis.  EXC 001 was co-discovered by Isis and Excaliard and developed by Excaliard for the treatment of skin scarring.  EXC 001 targets connective tissue growth factor, or CTGF, a growth factor that is over-expressed in damaged skin or tissue following a traumatic event.  In early 2011, Excaliard reported positive data from three Phase 2 studies demonstrating that EXC 001 significantly reduced scar severity in both hypertrophic and fine line scarring.  EXC 001 was safe and well tolerated in all subjects and is currently being evaluated in a Phase 2b study in patients following breast scar revision surgery.

ABOUT ISIS PHARMACEUTICALS, INC.

Isis is exploiting its leadership position in antisense technology to discov
'/>"/>

SOURCE Isis Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Sundia Receives 2011 Zero2IPO Venture 50 Award
2. Amsterdam Molecular Therapeutics Receives Orphan Designation in the European Union for Hemophilia B Gene Therapy
3. Vascular Designs, Inc. Receives CE Mark Approval for Its IsoFlow™ Infusion Catheter to Target Cancerous Tumors
4. Qualitest Pharmaceuticals Receives FDA Approval for Acetaminophen and Codeine Phosphate Oral Solution USP, 120mg/12mg per 5mL
5. First Patient Receives FDA-Approved Telescope Implant for End-Stage Macular Degeneration
6. Ethicon Endo-Surgery Receives 510(k) Clearance for New ENSEAL® G2 Curved and Straight Tissue Sealers Line -- Broadest Range of Advanced Bipolar Tissue Sealers Available for Open and Minimally Invasive Surgery
7. Nephros Receives Initial FDA Response to 510(k) Application for Hemodiafiltration System
8. New Web Technology Now Allows for Pharmaceutical Reps to Receive Training on Their Desktops, Tablets, and Smartphones
9. IDEV Technologies Receives FDA Clearance for Its SUPERA VERITAS® 6 French Stent Delivery System
10. Augurix Diagnostics Receives the 2011 Debiopharm /Valais Award for its Point-of-care Diagnostic Test for the Early Detection of Celiac Disease
11. The Childrens Hospital of Philadelphia Receives Grand Challenges Explorations Funding
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... Tenn. , Dec. 22, 2014   TRU-D ... automated, no-touch UV disinfection robot, announced today that the ... Schedule contract through November 2019.   This ... rapidly engage all levels of government purchasers, including Department ... as well as Homeland Security contacts purchasing solutions for ...
(Date:12/22/2014)... HOUSTON , Dec. 22, 2014 Cyberonics, Inc. ... devices for the treatment and management of epilepsy, today announced ... Morgan Healthcare Conference on Wednesday, January 14, 2015, in ... , Cyberonics, President and Chief Executive Officer, will speak at ... presentation can be accessed by clicking on the Investor Relations ...
(Date:12/22/2014)... , Dec. 22, 2014  Mark Farrah ... brief providing a summary of the 2015 marketplace ... enrollment trends.  According to a ... Planning and Evaluation, Department of Health and Human ... enrolled in individual medical plans through the Marketplace ...
Breaking Medicine Technology:TRU-D SmartUVC LLC Awarded General Services Administration Contract to Expand Government Customer Base 2Insights into the Marketplace and Individual Market Growth 2
... Meeting , , ATLANTA, Dec. ... the once-daily antiepileptic drug (AED) Keppra XR(TM) (levetiracetam) extended-release tablets ... additional dosing schedules. The data were among five studies that ... Epilepsy Society (AES) in Seattle. , ...
... Millennium: The Takeda Oncology Company today reported updated ... from the large, international Phase III VISTA(1) trial ... untreated multiple myeloma given VELCADE, melphalan and prednisone ... all patient sub-groups, including those with poor prognostic ...
Cached Medicine Technology:New Keppra XR(TM) Data Highlight Its Role for Patients with Partial-Onset Seizures 2New Keppra XR(TM) Data Highlight Its Role for Patients with Partial-Onset Seizures 3New Keppra XR(TM) Data Highlight Its Role for Patients with Partial-Onset Seizures 4New Keppra XR(TM) Data Highlight Its Role for Patients with Partial-Onset Seizures 5New Keppra XR(TM) Data Highlight Its Role for Patients with Partial-Onset Seizures 6Continued Overall Survival Advantage Reported From Pivotal Trial of VELCADE(R) (Bortezomib) for Injection Based Therapy in Patients With Previously Untreated Multiple Myeloma 2Continued Overall Survival Advantage Reported From Pivotal Trial of VELCADE(R) (Bortezomib) for Injection Based Therapy in Patients With Previously Untreated Multiple Myeloma 3Continued Overall Survival Advantage Reported From Pivotal Trial of VELCADE(R) (Bortezomib) for Injection Based Therapy in Patients With Previously Untreated Multiple Myeloma 4Continued Overall Survival Advantage Reported From Pivotal Trial of VELCADE(R) (Bortezomib) for Injection Based Therapy in Patients With Previously Untreated Multiple Myeloma 5Continued Overall Survival Advantage Reported From Pivotal Trial of VELCADE(R) (Bortezomib) for Injection Based Therapy in Patients With Previously Untreated Multiple Myeloma 6
(Date:12/26/2014)... 2014 Parker & Sons, Inc. ... in heating, cooling and plumbing contractor services throughout ... services in 2014 with regard to air-conditioning systems. ... is known for its incredibly hot summers. Working ... intricacies and details of a wide variety of ...
(Date:12/25/2014)... 2014 The click strand ... strength and durability. Today, the business announces a ... valid until Jan. 30, 2015. , Click strand ... hardwood. BambooFlooringChina.com is a well-known brand in the ... to find a reliable bamboo flooring supplier. , ...
(Date:12/25/2014)... 2014 Product liability lawsuits filed in ... ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in federal ... issued in the U.S. District Court, Northern District of ... open conference on January 7, 2015, at the Paul ... West Palm Beach, Florida. The Conference is scheduled to ...
(Date:12/25/2014)... Recently, Dylan Queen, a famous online company supplying ... of discounted prom dresses, most of which are priced ... the company, the promotion is valid until Jan. 22, ... the UK market. , The prom dresses in this ... styles: A-line strapless, empire strapless chiffon, one shoulder, floor-length, ...
(Date:12/25/2014)... sells many bamboo products and the business is famous ... announces big discounts on its bamboo mats , which ... the world’s leader in bamboo flooring. According to the ... 2015. , The bamboo mats are made from well-treated ... the bamboo strips for the mats are boiled and ...
Breaking Medicine News(10 mins):Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2
... June 2011 The Reed Elsevier Environmental Challenge aims ... and sustainable water supply for communities where it is ... $50,000 first prize, announced today, is Tagore-SenGupta Foundation. Their ... in remote villages and schools in Cambodia where arsenic ...
... highlights that while the risk of post-traumatic stress disorder (PTSD) ... migraine irrespective of sex, the risk is greater in male ... Headache: The Journal of Head and Face Pain , ... In this paper, lead author B. Lee Peterlin ...
... range of new "apps" and other technologies harnessing health ... demonstrated at the Health Data Initiative Forum, hosted by ... and Human Services, on Thursday, June 9. IT ... gather at the event hosted by the Institute of ...
... bona fide media presenting official press credentials , Media ... & IT support, English, Swedish, Spanish, German, and French ... is English] News briefings will be held:, ... CEST Monday 4 July (English), 14.00 hrs CEST Monday ...
... to suffer surgical site infections (SSIs) if the operating theatre ... of BJS, the British Journal of Surgery . ... surgery, exploring demographic parameters, the duration of the operation and ... per cent) developed SSIs and the only variable was the ...
... Asian non-small cell lung cancer (NSCLC) patients survive longer than ... first-line setting, and the effect was apparent both before and ... according to research published in the June issue of the ... Asian patients with a common type of lung cancer, the ...
Cached Medicine News:Health News:Reed Elsevier Environmental Challenge winners announced 2Health News:Sex matters -- more men with migraine suffer from PTSD than women 2Health News:Sex matters -- more men with migraine suffer from PTSD than women 3Health News:Health data forum features dynamic apps, experts on June 9 2Health News:European Society of Human Reproduction and Embryology Annual Meeting July 3-6, 2011, Stockholm 2Health News:European Society of Human Reproduction and Embryology Annual Meeting July 3-6, 2011, Stockholm 3Health News:Noisy operations associated with increased infections after surgery 2Health News:Asian lung cancer patient survival exceeds Caucasians' on multiple regimens 2
Electric high speed system....
Compressor-cooled plate used to keep blocks cold while sectioning....
... CO-Oximeter Control (Bayer 800 Series) is ... monitoring the performance of blood gas, ... 270 and 800 series) instrumentation. This ... Bayer 800 Rapidlab Series instruments in ...
Liquichek Blood Gas Plus CO-Oximeter Control (IL Synthesis Series) is a combination control for use in monitoring the performance of blood gas, ion-selective electrode, biosensor and CO-Oximetry anal...
Medicine Products: