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Isis to Receive Up to $14 Million from Pfizer for Its Acquisition of Excaliard Pharmaceuticals
Date:11/22/2011

Phase 2, creating a strong clinical data package for this potentially breakthrough therapy.  Pfizer will provide additional drug development expertise and experience to support the continued advancement of EXC 001.  The market opportunity to treat disfiguring scars is very large, and we are pleased to have created an opportunity to participate in it through EXC 001 and Excaliard."

"CTGF has been an interesting target for fibrosis for years, and now we have the clinical data that Excaliard generated with EXC 001, which shows the importance of CTGF for the treatment of fibrotic disorders," said Brett Monia, Ph.D., Vice President, Drug Discovery and Corporate Development at Isis.  "We have been successfully pursuing systemic applications for CTGF, which differs from the local applications pursued by Excaliard, to treat a range of fibrotic diseases and look forward to advancing our program toward clinical development."

Isis and Excaliard entered into a collaboration in 2007 to discover and develop antisense drugs for the local treatment of fibrotic diseases, including scarring.  Excaliard is a private company funded by Rivervest Venture Partners, Alta Partners, Proquest Investments and Isis.  EXC 001 was co-discovered by Isis and Excaliard and developed by Excaliard for the treatment of skin scarring.  EXC 001 targets connective tissue growth factor, or CTGF, a growth factor that is over-expressed in damaged skin or tissue following a traumatic event.  In early 2011, Excaliard reported positive data from three Phase 2 studies demonstrating that EXC 001 significantly reduced scar severity in both hypertrophic and fine line scarring.  EXC 001 was safe and well tolerated in all subjects and is currently being evaluated in a Phase 2b study in patients following breast scar revision surgery.

ABOUT ISIS PHARMACEUTICALS, INC.

Isis is exploiting its leadership position in antisense technology to discov
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