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Isis and Collaborators Present New Research at the ATVB Annual Conference
Date:5/1/2009

the near-term to our cardiovascular pipeline, which already includes mipomersen, a CRP inhibitor and a PCSK9 inhibitor is quite exciting," said Richard Geary, Ph.D., Senior Vice President of Development at Isis Pharmaceuticals. "Inhibiting apoC-III is a promising new way to lower triglycerides to treat a potential independent risk factor for cardiovascular disease. Futhermore, the anti-atherotic effect of lowering apoC-III, which we have seen in animals, suggests that lowering apoC-III could produce reductions in atherosclerosis in man as well."

Finally, Isis and collaborators reported on the effects of antisense drugs targeting 11 beta-HSD1 and apoF. In a presentation titled "Antisense-mediated inhibition of 11 beta-HSD1 significantly decreases hepatic lipogenesis, triglyceride content and triglyceride secretion" Isis collaborator, G. Li from Columbia University, showed that antisense inhibition of 11 beta-HSD1 reduced triglycerides in both liver and blood, while also reducing body fat in animal models. 11 beta-HSD1 is an enzyme that inactivates steroids and may contribute to metabolic disease, suggesting the potential therapeutic benefit of antisense drugs inhibiting 11 beta-HSD1 to treat high triglycerides and diabetes. In a presentation titled "In vivo knock down of apolipoprotein F decreases liver triglyceride levels" S. Khetarpal from University of Pennsylvania presented research demonstrating that antisense drugs that selectively inhibit apoF reduced triglycerides in blood and liver. ApoF is another protein that carries triglycerides in blood and could offer potential therapeutic benefit in patients with diseases associated with elevated triglycerides including cardiovascular disease.

"The efficiency of our drug discovery platform offers us virtually unlimited opportunities to expand the scope of diseases we can treat with antisense drugs. We have shown that antisense inhibition of a number of ne
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SOURCE Isis Pharmaceuticals, Inc.
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