Navigation Links
Isis and Collaborators Present New Research at the ATVB Annual Conference
Date:5/1/2009

vels of triglycerides and apoC-III.

Isis scientist, J. Crosby, presented new research titled "Antisense oligonucleotide-mediated depletion of Factor XI results in effective anticoagulation with a favorable risk/benefit profile in mice" demonstrating that antisense drugs that inhibit Factor XI can prevent thrombus formation in models of stroke without causing an increase in bleeding, the most common side effect observed with currently available antithrombotic agents. The Isis antisense drug inhibiting Factor XI is in advanced research and representative of significant advances in creating antisense drugs that can more safely reduce undesired clotting.

"Factor XI is the first representative drug candidate for development from our new thrombosis effort. It is another example of the power of our antisense technology to develop new drugs to nearly any genomic target," said Brett Monia, Ph.D., Vice President of Drug Discovery and Corporate Development at Isis Pharmaceuticals. "After rapidly and efficiently evaluating individual clotting factors produced in the liver, we selected Factor XI as the optimal target to inhibit thrombosis without causing bleeding. In addition to Factor XI, we will have drugs that inhibit other individual clotting factors that demonstrate potential therapeutic benefit and represent other novel approaches to treating cardiovascular disease."

Isis scientist, A. Mullick, also presented new research titled "Antisense inhibition of apolipoproteinC-III mitigated features of metabolic syndrome and reduced atherosclerosis in LDL receptor knockout mice" showing the ability of antisense drugs in a late-stage research program targeting apoC-III to selectively reduce triglycerides in both liver and blood. Antisense drugs that selectively reduced levels of apoC-III dramatically reduced triglycerides and atherosclerosis in animal models.

"The potential to add an apoC-III inhibitor in
'/>"/>

SOURCE Isis Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
All rights reserved

2

GOOD

Page: 1 2 3 4 5

Related medicine technology :

1. Novel PCT Method Unveiled by Pressure BioSciences, Inc. and Collaborators at the Harvard School of Public Health
2. Rosetta Genomics and Collaborators Identify MicroRNAs That Can Accurately Discriminate Between Primary and Metastatic Tumors in the Brain
3. Ironwood and Collaborators Present Preclinical Data Demonstrating That Cyclic GMP Alleviates Intestinal Pain
4. Vicus Therapeutics to Present at the 234th American Chemical Society National Meeting in Boston, MA
5. Lexicon to Present Research Results at American Chemical Society Meeting Regarding Target of LX1031 Drug Candidate
6. Genaera Corporation Presents Interim Phase 1 Data for Obesity Compound Trodusquemine (MSI-1436) at IBC Conference
7. Quark Pharmaceuticals, Inc. Presented Positive Preclinical Results of Systemic RNAi Compound for Acute Renal Failure (ARF)
8. Intellect Neurosciences, Inc. to Present Data on Alzheimers Vaccine at 13th International Congress of Immunology Conference
9. CV Therapeutics Announces Eight Abstracts Accepted for Presentation at the European Society of Cardiology Congress 2007
10. Pre-clinical Data on Recent Advances with HIV VLP Vaccine Presented at AIDS Vaccine 07 Conference
11. Iomai Announces Data from Phase 2 Field Study of Travelers Diarrhea Vaccine Accepted for Presentation at ICAAC
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/20/2013)... ALEXANDRIA, Va. , May 20, 2013   ... B. Douglas Hoey , RPh, MBA issued the ... Hart Research Associates regarding Medicare Part D "preferred ... pharmacies from offering patients the plan,s lowest advertised co-payments: ... "Officials with Medicare and MedPAC , ...
(Date:5/20/2013)... MAPLE GROVE, Minn. , May 20, 2013 ... committed to the development of new treatments for ... the launch of its newly designed website, ... through images and narratives.  As part of the ... – our new branding campaign centers around people ...
(Date:5/20/2013)... 20, 2013 /PRNewswire-iReach/ -- Today at American Society ... Christine Ginocchio discussed Specific Technologies blood ... identification of microorganisms producing bloodstream infection. Dr. Ginocchio ... the Division of Infectious Disease Diagnostics at North ... non-sectarian health system. (Photo: http://photos.prnewswire.com/prnh/20130520/CG16829 ...
Breaking Medicine Technology:Poll: Over One Million Seniors Have Problems with Medicare 'Preferred Pharmacy' Drug Plans 2Poll: Over One Million Seniors Have Problems with Medicare 'Preferred Pharmacy' Drug Plans 3Poll: Over One Million Seniors Have Problems with Medicare 'Preferred Pharmacy' Drug Plans 4Upsher-Smith Introduces Newly Redesigned Corporate Website 2Specific Technologies Bloodstream Infection Identification Solutions Discussed at the American Society for Microbiology Conference by Award Lecturer Christine Ginocchio 2Specific Technologies Bloodstream Infection Identification Solutions Discussed at the American Society for Microbiology Conference by Award Lecturer Christine Ginocchio 3
... 8, 2012 /PRNewswire-Asia / -- WuXi PharmaTech (Cayman) Inc. ... and medical device R&D outsourcing company with operations in ... will release financial results for the fourth quarter of ... Thursday, March 8, 2012 (which will be Friday morning, ...
... SACRAMENTO, Calif., Feb. 7, 2012 Sutter Medical Center, ... nation and the first in California to receive full ... Centers (SCPC). The announcement comes as the nation ushers in ... is the most common cardiac arrhythmia that can lead ...
Cached Medicine Technology:WuXi PharmaTech Schedules Fourth-Quarter 2011 Earnings Release 2Sutter Medical Center First in California to Receive Atrial Fibrillation Certification 2
(Date:5/20/2013)... 2013) - A new "telerehabilitation" approach lets physical therapists ... Internet, with good accuracy compared with face-to-face examinations, reports ... Spine . The journal is published ... of Wolters Kluwer Health . , Taking advantage ... a more feasible alternative to in-person clinic visits, according ...
(Date:5/20/2013)... May 20, 2013 Medicare Part D ... satisfied, citing lower costs, convenient access to pharmacies and ... Research Associates released today by the Pharmaceutical Care Management ... (9.5 million) are currently enrolled in plans with preferred ... and overall value of plans with preferred pharmacy networks,” ...
(Date:5/20/2013)... 2013 Cliff Lake Dental Care is pleased to ... schedules when visiting the dentist office . The change was ... schedule. , Here are the new office hours: Mondays- 8 a.m. ... 8 a.m. to 1 p.m. and 2-5 p.m., Thursdays 7 a.m. ... will be open to take appointments only. Cliff Lake Dental wants ...
(Date:5/20/2013)... 20, 2013 A pioneer and ... solutions, i2i Systems announced today that ... Foundation (SCF) selected i2iTracks as their population management ... meet their Meaningful Use (MU), Government Performance and ... requirements – a welcomed solution to managing the ...
(Date:5/20/2013)... May 20, 2013 Selexis SA, a ... identification and cell line development for scale-up and manufacturing ... co-founder will present data on the Company’s core technology ... Engineering Conference, May 20 - 23 at the Hyatt ... Selexis’ co-founder and scientific advisory board member, Nicolas Mermod, ...
Breaking Medicine News(10 mins):Health News:Telerehabilitation allows accurate assessment of patients with low back pain 2Health News:Telerehabilitation allows accurate assessment of patients with low back pain 3Health News:Survey: 85% of Part D Seniors in Preferred Pharmacy Plans are Satisfied With Costs, Pharmacy Choices 2Health News:Cliff Lake Dental Care Announces Office Hours Change 2Health News:Baldrige Award Winner Southcentral Foundation Selects i2iTracks Population Health Intelligence Solution to Support Meaningful Use, GPRA and UDS Reporting Requirements 2Health News:Baldrige Award Winner Southcentral Foundation Selects i2iTracks Population Health Intelligence Solution to Support Meaningful Use, GPRA and UDS Reporting Requirements 3Health News:Selexis SA to Present Technology Platform Data at Cell Line Development & Engineering 2Health News:Selexis SA to Present Technology Platform Data at Cell Line Development & Engineering 3
... new but today there is a growing industry catering to ... National Guard Sgt. Darrell "J.R." Salzman has learned to tie ... shiny metal hook that serves as his right called Utah ... myoelectric Utah Arm, made by Motion Control Inc., of Salt ...
... number of doctors in Portugal were refusing to carry out ... the 10th week of pregnancy . ,The law ... at least nine public hospitals out of a total of ... approved the law in March after a February referendum found ...
... Asbestos Saskatchewan committee, the Canadian Cancer Society's call for a ... is welcomed news and reflects a changing environment. ,"Obviously ... Canada of public interests and social justice organizations to put ... political agenda, Sass was quoted.,"Up to now it has not ...
... will build a 60-acre health and education complex in Islamabad ... people of the capital and the twin city of Rawalpindi ... residential development plan to develop a Health and Education City ... colleges of medicine, nursing, and dentistry. ,Harvard ...
... A new study has found that divorce, not shared genetic ... to the higher rates of break-ups experienced by the offspring ... study to look at genetics as a reason in the ... found that the parents' divorce itself, played a key role ...
... of children ages 5 to 7,C-reactive protein, a marker ... disease, may also indicate cognitive impairment in children ... OSA have increased levels of hsCRP [high-sensitivty C-reactive protein] ... David Gozal, M.D., of the University of Louisville in ...
Cached Medicine News:Health News:War Stimulates Research Blitz in Prosthetics Industry 2Health News:Move To Ban Asbestos Welcomed 2Health News:Genetics is Not the Reason for Family Break-ups 2Health News:C -reactive Protein is the Marker for Cardiovascular Disease 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: