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Isis and Collaborators Present New Research at the ATVB Annual Conference
Date:5/1/2009

vels of triglycerides and apoC-III.

Isis scientist, J. Crosby, presented new research titled "Antisense oligonucleotide-mediated depletion of Factor XI results in effective anticoagulation with a favorable risk/benefit profile in mice" demonstrating that antisense drugs that inhibit Factor XI can prevent thrombus formation in models of stroke without causing an increase in bleeding, the most common side effect observed with currently available antithrombotic agents. The Isis antisense drug inhibiting Factor XI is in advanced research and representative of significant advances in creating antisense drugs that can more safely reduce undesired clotting.

"Factor XI is the first representative drug candidate for development from our new thrombosis effort. It is another example of the power of our antisense technology to develop new drugs to nearly any genomic target," said Brett Monia, Ph.D., Vice President of Drug Discovery and Corporate Development at Isis Pharmaceuticals. "After rapidly and efficiently evaluating individual clotting factors produced in the liver, we selected Factor XI as the optimal target to inhibit thrombosis without causing bleeding. In addition to Factor XI, we will have drugs that inhibit other individual clotting factors that demonstrate potential therapeutic benefit and represent other novel approaches to treating cardiovascular disease."

Isis scientist, A. Mullick, also presented new research titled "Antisense inhibition of apolipoproteinC-III mitigated features of metabolic syndrome and reduced atherosclerosis in LDL receptor knockout mice" showing the ability of antisense drugs in a late-stage research program targeting apoC-III to selectively reduce triglycerides in both liver and blood. Antisense drugs that selectively reduced levels of apoC-III dramatically reduced triglycerides and atherosclerosis in animal models.

"The potential to add an apoC-III inhibitor in
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SOURCE Isis Pharmaceuticals, Inc.
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