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Isis Selects Development Candidate, Isis-AATRx, to Treat AATD-Associated Liver Disease
Date:10/11/2011

ich can progressively accumulate in the liver and cause liver disease.  Patients who inherit a mutant gene from both parents are characterized as severe AATD and are at increased risk for developing serious lung conditions, including emphysema, chronic obstructive pulmonary disease, asthma and chronic bronchitis.  Furthermore, approximately 10 percent of infants and 15 percent of adults with severe AATD experience liver damage.  ISIS-AAT Rx is designed to inhibit the production of abnormal AAT in patients with AATD and prevent accumulation of misfolded AAT in the liver, offering a potentially unique approach to treat AATD-associated liver disease.  

ABOUT ISIS PHARMACEUTICALS, INC.

Isis is exploiting its leadership position in antisense technology to discover and develop novel drugs for its product pipeline and for its partners.  Isis' broad pipeline consists of 24 drugs to treat a wide variety of diseases with an emphasis on cardiovascular, metabolic and severe and rare/neurodegenerative diseases, and cancer.  Isis' partner, Genzyme, plans to commercialize Isis' lead product, mipomersen, following regulatory approval, which is expected in 2012.  Isis' patents provide strong and extensive protection for its drugs and technology.  Additional information about Isis is available at www.isispharm.com.

ISIS PHARMACEUTICALS' FORWARD-LOOKING STATEMENT

This press release includes forward-looking statements regarding Isis' collaboration with GlaxoSmithKline, the discovery, development and potential of drugs for severe and rare diseases, and the development, activity, therapeutic potential and safety of ISIS-AAT Rx.  Any statement describing Isis' goals, expectations, financial or other projections, intentions or beliefs, including the planned commercialization of mipomersen, is a forward-looking statement and should be considered an at-risk statemen
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SOURCE Isis Pharmaceuticals, Inc.
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