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Isis Reports Strong Financial Results and Highlights for Second Quarter of 2009
Date:8/6/2009

uticals, Inc. common stockholders $(0.03) $0.02 $0.02 $(0.04) Net income (loss) from discontinued operations - (0.06) 1.54 (0.06) ------- ------- ------- ------- Diluted net income (loss) $(0.03) $(0.04) $1.56 $(0.10) ======= ======= ======= ======= Shares used in computing diluted net income (loss) per share 98,116 94,675 111,608 92,737 ======= ======= ======= ======= (1) Adjusted for the required retrospective adoption of FSP 14-1 and SFAS 160.

                                Isis Pharmaceuticals, Inc.
            Reconciliation of Isis' 2008 Historical Statement of Operations
                         (In Thousands, Except Per Share Data)

                                Historical Isis
                                Pharmaceuticals,                      Adjusted
                                     Inc.                               six
                                  Six months                           months
                                    Ended                              ended
                                   June 30,   Discontinued    FSP     June 30,
                                    2008(1)   Operations(2)  14-1(3)    2008
                                ----------------------------------------------
    Revenue:                                       (unaudited)
      Research and development
       revenue under
       collaborative agreements    $47,499        $(6,237)      $-    $41,262
      Licensing and royalty
       revenue                       6,815              -        -      6,815
                                   -------        -------   ------    -------
        Total re
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SOURCE Isis Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
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