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Isis Reports Strong Financial Results and Highlights for Second Quarter of 2009
Date:8/6/2009

Phase 1 study of LY2181308 and presented data confirming that LY2181308 penetrates tumor tissue and reduces survivin mRNA and protein levels in tumor cells.

Isis and its collaborators highlighted new antisense therapeutic programs and targets to treat metabolic diseases, including obesity, at the American Diabetes Association (ADA) scientific sessions.

  • Isis presented new preclinical data on ISIS-SGLT2Rx showing robust and sustained reduction in SGLT2 levels that resulted in a significant reduction in blood glucose levels in multiple animal species.
  • Isis and its collaborators presented data on a number of other promising new diabetes and anti-obesity targets demonstrating that reducing levels of these targets with antisense drugs can significantly lower blood glucose levels, increase the body's sensitivity to insulin, and reduce fat mass and body weight in animals.

Isis partnered with non profit foundations to pursue new treatments for debilitating diseases, such as severe neurodegenerative diseases.

Isis was awarded a grant from the Michael J. Fox Foundation's Therapeutic Development Initiative program for the discovery and development of an antisense drug for the treatment of Parkinson's Disease.

Isis benefits from its partners as they advance RNA-based technologies and develop drugs that incorporate Isis' technology resulting in financial benefits as these assets mature.

  • Isis earned milestone payments from Archemix and Alnylam because each company advanced drugs that incorporate Isis' technology.
  • Isis co-exclusively licensed its single-stranded RNA interference (ssRNAi) technology to Alnylam as part of a new strategic initiative to continue to develop the ssRNAi platform.
  • Regulus achieved its first milestone in its infl
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SOURCE Isis Pharmaceuticals, Inc.
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