Navigation Links
Isis Reports Phase 2 Data on ISIS-APOCIII Rx Showing Substantial Reductions of Triglycerides and Apoc-III in Patients with Familial Chylomicronemia
Date:9/21/2013

CARLSBAD, Calif., Sept. 21, 2013 /PRNewswire/ -- Isis Pharmaceuticals, Inc. (NASDAQ: ISIS) announced data from a Phase 2 study of ISIS-APOCIIIRx as a monotherapy in patients with familial chylomicronemia syndrome, or FCS.  FCS is a rare orphan disease characterized by severely high triglyceride levels that affects an estimated 3,000 to 5,000 patients worldwide.  These data were presented today by Dr. Daniel Gaudet at the National Lipid Association clinical lipid update meeting in Baltimore, MD.  In this study, three patients with FCS treated with ISIS-APOCIIIRx achieved substantial reductions in triglycerides with all three patients achieving a triglyceride level below 500 mg/dL, which substantially reduces the risk of an acute pancreatic event.  Patients also achieved substantial reductions in apoC-III and apoCIII-associated very low-density lipoprotein-cholesterol (VLDL-C) particles. 

(Logo:  http://photos.prnewswire.com/prnh/20130807/LA60006LOGO)

"Familial chylomicronemia is a rare and very serious genetic disorder that is often associated with triglyceride levels higher than 2,000 mg/dL.  FCS patients with triglyceride levels this high often experience a significant number of health problems such as abdominal pain, eruptive fatty skin lesions, enlargement of the liver and spleen, and recurrent acute pancreatitis that often requires hospitalization.  Current treatment approaches are usually ineffective in FCS patients and, as a result, FCS patients are required to severely limit their dietary fat intake.  Despite these very restrictive measures, many FCS patients are still unable to lower their triglycerides enough to eliminate the risk of health
'/>"/>

SOURCE Isis Pharmaceuticals, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Qmed, the Leading Global MedTech Industry Resource, Partners with Clarimed, to Provide the Medical Manufacturing and Healthcare Industry with FDA Reports on Adverse Events
2. Sigma-Aldrich (NASDAQ: SIAL) Reports Q1 2012 Diluted EPS of $0.96, With Diluted Adjusted EPS of $0.99. Sales Increase 5% for Q1 2012. Full Year 2012 Diluted Adjusted EPS Outlook of $3.90 to $4.05 Reaffirmed.
3. Kelyniam Global Inc. Reports Record Cranial Implant Revenues in the 1st Quarter of 2012
4. Varian Medical Systems Reports Results for Second Quarter of Fiscal Year 2012
5. Mylan Reports Q1 2012 Adjusted Diluted EPS of $0.52, an 18% Increase Over Prior Year Quarter
6. CryoLife Reports Record Quarterly Revenues in First Quarter of 2012
7. PAREXEL Reports Third Quarter Fiscal Year 2012 Financial Results
8. Luminex Corporation Reports First Quarter 2012 Results
9. Hospira Reports First-Quarter 2012 Results
10. Endo Reports First Quarter Financial Results And Announces Return To Steady Supply Of OPANA® ER And Voltaren® Gel
11. The Female Health Company Reports Second Quarter Operating Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... , July 28, 2014 /PRNewswire-iReach/ -- June 28 th , ... which has developed the AMAS cancer test, is making its ... To date, the test, which is a serum-based in vitro ... emerging as a significant tool in the fight against cancer ... With an estimated 17 million cancer survivors in the ...
(Date:7/28/2014)... , July 28, 2014  Surgical Theater, LLC ... to its Business Advisory Board. New members include ... President for Business Development and New Technologies for ... , former Senior Vice President and General Manager ... Theater applies flight simulation technology to brain surgery ...
(Date:7/28/2014)... , July 28, 2014  VigeneTech, Inc, in ... of LEGENDplex™ Data Analysis Software, an OEM software ... cytometers.  BioLegend develops and offers varieties of bead-based ... With the support of VigeneTech,s data analysis software, ... analyzed and easily reported LEGENDplex™ ...
Breaking Medicine Technology:Oncolab, Inc. Exhibits Pioneering AMAS Cancer Test at AACC 2Surgical Theater Names Former Given Imaging Ltd. and Philips Healthcare Executives to Business Advisory Board 2Surgical Theater Names Former Given Imaging Ltd. and Philips Healthcare Executives to Business Advisory Board 3Surgical Theater Names Former Given Imaging Ltd. and Philips Healthcare Executives to Business Advisory Board 4Surgical Theater Names Former Given Imaging Ltd. and Philips Healthcare Executives to Business Advisory Board 5VigeneTech Releases New Powerful Software for Flow Cytometry Data Analysis 2
... LAKE CITY, Jan. 28, 2011 TechniScan (OTC Bulletin ... engaged in the development and commercialization of an automated ... Robinson, Chief Executive Officer, will present at RetailInvestorConferences.com. DATE: ... ESTLINK: , www.retailinvestorconferences.com This will be a live, ...
... BioSciences, Inc. (NasdaqCM: DARA), a biopharmaceutical development company ... through proof of concept in humans for subsequent ... today that Richard Franco, CEO, will present at ... 5:00 PM ESTLINK: , www.retailinvestorconferences.com This will ...
Cached Medicine Technology:TechniScan to Present Live, Online at RetailInvestorConferences.com on February 3rd 2DARA BioSciences to Present Live at RetailInvestorConferences.com on February 3 2DARA BioSciences to Present Live at RetailInvestorConferences.com on February 3 3
(Date:7/28/2014)... 28, 2014 (HealthDay News) -- Endurance runners are far ... undetected heart condition, according to a new study. ... in events in warm climates are actually 10 times ... Yet, the less common sudden death of a young ... such as an irregular heartbeat, often gets a lot ...
(Date:7/28/2014)... not divide unless there is enough oxygen present to ... cell types circumvent this rule. Researchers at The Johns ... the cells, warning signals, enabling cancers to continue to ... process, the researchers found that lysosomes the cell,s ... They also uncovered new evidence that certain drugs can ...
(Date:7/28/2014)... 2014 Parker Waichman LLP, a personal injury ... that the heroes of 9/11 are never forgotten, comments that ... important deadline. According to a VCF message dated ... cancer on or before October 12, 2012 must file a ... and others who were allegedly injured by the toxic dust ...
(Date:7/28/2014)... NY (PRWEB) July 28, 2014 The ... organization that has donated more than 200,000 books to ... 2001, announces the launch of Brooke’s Cooks, a new ... while encouraging healthy living among at-risk children and their ... will include a series of nutrition information workshops, cooking ...
(Date:7/28/2014)... July 28, 2014 Bariatric Eating, a ... announced that it will be introducing three additional flavors ... this summer. The additional flavors include: , Inspire Summer ... protein , Inspire Pomegranate Razz Berry -­ Pomegranate, razz ... soft-serve vanilla cone , Bariatric Eating's Inspire protein ...
Breaking Medicine News(10 mins):Health News:Heat Stroke a Greater Threat to Endurance Runners Than Heart Problems: Study 2Health News:Cell's recycling center implicated in division decisions 2Health News:October 12, 2014 Deadline Approaching for 9/11 First Responders Suffering from Certain Cancers to Submit Their Registration to the VCF, Parker Waichman LLP Comments 2Health News:October 12, 2014 Deadline Approaching for 9/11 First Responders Suffering from Certain Cancers to Submit Their Registration to the VCF, Parker Waichman LLP Comments 3Health News:Brooke Jackman Foundation Launches Brooke's Cooks, New Initiative to Promote Healthy Living Among At-Risk Youth and Their Families 2Health News:Brooke Jackman Foundation Launches Brooke's Cooks, New Initiative to Promote Healthy Living Among At-Risk Youth and Their Families 3Health News:Brooke Jackman Foundation Launches Brooke's Cooks, New Initiative to Promote Healthy Living Among At-Risk Youth and Their Families 4Health News:Bariatric Eating Announces Three New Protein Shake Flavors 2
... a night,s rest may be the cause, research finds , ... the body,s production of the hormone melatonin, potentially leading to ... people often have problems with sleep after a brain injury, ... these problems," study author Shantha Rajaratnam of Monash University in ...
... is available by prescription under trade name Xenical and ... -- Responding to reports of rare but sometimes severe ... announced revised labels for a widely used weight-loss drug. ... the trade name Xenical and over-the-counter as Alli. , ...
... idea of individualized therapies, experts say , WEDNESDAY, May 26 ... not two, but potentially tens of thousands of genetic mutations ... A sample from a lung tumor from a heavy smoker ... 27 issue of Nature . , "People in the ...
... of individualized therapies, experts say , WEDNESDAY, May 26 (HealthDay ... two, but potentially tens of thousands of genetic mutations which, ... sample from a lung tumor from a heavy smoker revealed ... issue of Nature . , "People in the field ...
... development of a fast, simple, inexpensive method for determining ... skin allergies in people -- a method that does ... ACS, Chemical Research in Toxicology , a monthly ... the existence of public sentiment against the use of ...
... 26, 2010) Joan W. Miller, M.D., the HMS Henry ... of ophthalmology at Massachusetts Eye and Ear Infirmary and the ... Martin Dean,s Leadership Award for the Advancement of Women Faculty. ... was initiated by Joseph Martin, former HMS dean, in 1998. ...
Cached Medicine News:Health News:Brain Injuries May Lead to Sleep Woes 2Health News:Rare Cases of Liver Damage Tied to Weight-Loss Drug 2Health News:Rare Cases of Liver Damage Tied to Weight-Loss Drug 3Health News:Single Lung Tumor Contains 50,000 Mutations 2Health News:Single Lung Tumor Contains 50,000 Mutated Genes 2Health News:Joan Miller, M.D., receives 2010 Leadership Award for the Advancement of Women Faculty 2
... The NU-5510 DHD AutoFlow Direct ... HEPA filtration guarantying the greatest control ... cycles, both at 95C wet decontamination ... are exceptionally useful for cell line ...
... upright freezer uses ultra-thin vacuum insulation ... urethane insulation, to increase storage capacity, ... (336) 2" boxes or 3,336 samples. ... reduces energy consumption and extends compressor ...
... Advanced Series CO2 Incubators ... reliability. Microprocessor achieves precise temperature ... natural evaporation & RH% is ... CO2 and RH are displayed ...
... incubator with 6-sided direct heating provides ... lighter-weight incubator with greater internal storage ... HEPA filtered CO2 inlet, heated outer ... fanless, convection air circulation optimize culture ...
Medicine Products: