Navigation Links
Isis Reports Phase 2 Data on ISIS-APOCIII Rx Showing Significant Reductions of ApoC-III and Triglycerides in Patients With High Triglycerides Taking Fibrates
Date:7/22/2013

es, rapid, robust reductions in apoC-III and triglycerides were observed.  The positive effect of ISIS-APOCIIIRx on other key lipid parameters demonstrates the potential for ISIS-APOCIIIRx to provide therapeutic benefit to patients with very high triglycerides."

In this study, 26 patients received either 200 mg or 300 mg dose of ISIS-APOCIIIRx, or placebo via weekly subcutaneous injections.  All patients were on stable doses of fibrates with average baseline levels of fasting triglycerides between 282 mg/dL and 457 mg/dL.  The three groups of patients were reasonably well balanced in baseline characteristic. 

In this study ISIS-APOCIIIRx was found to be generally safe and well tolerated.  The most common adverse event (AE) was injection site reactions, which were infrequent and consisted of mild erythema that typically resolved within one to two days.
There were no flu-like symptoms, no elevations of liver enzymes greater than three times upper limit of normal, no abnormalities in renal function and no clinically meaningful changes in other laboratory values.  There was one patient who, four days after treatment, experienced a transient episode of a rash, low-grade fever, chills and headache, which resolved completely. This event was reported by the investigator as related to treatment, and classified as a serum sickness-like reaction (a serious AE). Subsequent detailed investigations demonstrated that it was not serum sickness.

"We are very encouraged by the two sets of positive data we have reported this summer demonstrating that treatment with ISIS-APOCIIIRx produced highly statistically significant and clinically meaningful reductions in apoC-III and triglycerides, and increases in HDL-C in patients with high triglycerides.  In addition, the positive effect of ISIS-APOCIIIRx treatment on lipid parameters, improvements in glucose control a
'/>"/>

SOURCE Isis Pharmaceuticals, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Qmed, the Leading Global MedTech Industry Resource, Partners with Clarimed, to Provide the Medical Manufacturing and Healthcare Industry with FDA Reports on Adverse Events
2. Sigma-Aldrich (NASDAQ: SIAL) Reports Q1 2012 Diluted EPS of $0.96, With Diluted Adjusted EPS of $0.99. Sales Increase 5% for Q1 2012. Full Year 2012 Diluted Adjusted EPS Outlook of $3.90 to $4.05 Reaffirmed.
3. Kelyniam Global Inc. Reports Record Cranial Implant Revenues in the 1st Quarter of 2012
4. Varian Medical Systems Reports Results for Second Quarter of Fiscal Year 2012
5. Mylan Reports Q1 2012 Adjusted Diluted EPS of $0.52, an 18% Increase Over Prior Year Quarter
6. CryoLife Reports Record Quarterly Revenues in First Quarter of 2012
7. PAREXEL Reports Third Quarter Fiscal Year 2012 Financial Results
8. Luminex Corporation Reports First Quarter 2012 Results
9. Hospira Reports First-Quarter 2012 Results
10. Endo Reports First Quarter Financial Results And Announces Return To Steady Supply Of OPANA® ER And Voltaren® Gel
11. The Female Health Company Reports Second Quarter Operating Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... Mass. , Jan. 15, 2014  Zafgen, Inc., ... unmet needs of severely obese patients, today announced ... beloranib, a selective inhibitor of methionine aminopeptidase 2 ... severe form of genetic obesity.  These results showed ...
(Date:1/14/2014)... FRAMINGHAM, Mass. , Jan. 14, 2014 ... a leading innovator of less invasive, miniaturized circulatory support ... failure, today announced that it expects revenues for the ... bringing expected full-year 2013 revenues to approximately $208 million. ...
(Date:1/14/2014)... North America,s leading business partnering event ... 30 th edition of its annual conference at the ... 21-24. (Logo: http://photos.prnewswire.com/prnh/20131028/NY05330LOGO-a ) ... specialty chemical companies will take part in the conference, which ...
Breaking Medicine Technology:Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 2Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 3Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 4HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 2HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 3HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 4Media Advisory: InformEx 2014 Events & Speaker Lineup for 30th Edition Conference in Miami Beach 2
... Ridge Diagnostics, Inc., a neurodiagnostic company, announced ... Annual Neurotech Investing and Partnering Conference to be held in ... 9th and 10th.   Ms. Williams, a clinical ... Generation Psychiatry" lead by Dr. Manuel Lopez-Figueroa, Vice President, Bay ...
... N.C., May 4, 2011 INC Research, LLC, a ... by Avista Capital Partners and Ontario Teachers, Pension Plan, ... today jointly announced a definitive merger agreement under which ... with a total equity value of approximately $232 million. ...
Cached Medicine Technology:Ridge Diagnostics, Inc. CEO to Speak at Neurotech Investing and Partnering Conference 2INC Research to Acquire Kendle International for $15.25 per Share in Cash 2INC Research to Acquire Kendle International for $15.25 per Share in Cash 3INC Research to Acquire Kendle International for $15.25 per Share in Cash 4INC Research to Acquire Kendle International for $15.25 per Share in Cash 5INC Research to Acquire Kendle International for $15.25 per Share in Cash 6
(Date:4/24/2014)... An Oregon State University researcher has found a relationship ... symptoms of autism spectrum disorder in very young children. ... first to show a direct relationship between motor skills ... gross motor skills should be included in treatment plans ... assistant professor in OSU,s College of Public Health and ...
(Date:4/24/2014)... first flu pandemic in the 21st century. The virus ... 50 people in the country. Since 2011 the pH1N1 ... , Infections with influenza pH1N1 virus vary from ... recommended Tamiflu for treatment of patients with severe or ... it targets viral proteins which mutate quickly and the ...
(Date:4/23/2014)... A pilot study by Massachusetts General Hospital (MGH) investigators ... unusual treatment for a serious medical problem use ... diarrhea caused by the Clostridium difficile ( ... published online in the journal Clinical Infectious Diseases ... fecal material from donors unrelated to patients was as ...
(Date:4/23/2014)... April 24, 2014 Pregnant immigrants from Sub-Saharan ... increased monitoring during pregnancy, according to new research ... today in the British Journal of Obstetrics ... and eclampsia rates among immigrants and native-born women ... (Ontario), Denmark, Sweden, Spain (Catalonia and Valencia) and ...
(Date:4/23/2014)... Washington State University Spokane have developed a new ... nod off behind the wheel. , Their recently ... are more variable in drowsy driversand offers an ... video-based driver drowsiness detection systems. , Van Dongen"Video-based ... car is drifting out of its lane are ...
Breaking Medicine News(10 mins):Health News:Motor skill deficiencies linked to autism severity in new research 2Health News:Use of frozen material for fecal transplant successfully treats C. difficile infection 2Health News:Use of frozen material for fecal transplant successfully treats C. difficile infection 3Health News:Pregnancy complications may be more common in immigrants from certain regions 2Health News:WSU innovation improves drowsy driver detection 2
... show a tendency in the standard laboratory test toward "dose ... unsafe manner in patients who have consumed alcohol should ... in people. That,s the conclusion of a review of ... Pharmaceutics , a bi-monthly journal. In the article, ...
... ... unwavering commitment , ... (Vocus) September 23, 2009 -- Every September, thousands of BC students enroll in university or ... large number of them, student life will bring a host of challenges ranging from financial ...
... , , ... for Disease Control and Prevention (CDC), recommend seasonal influenza vaccination ... against the influenza virus. , , To ... seasonal influenza vaccination, the American Lung Association of Ohio is ...
... , , ANNAPOLIS, Md., Sept. 23 ... company developing medical countermeasures against biological and chemical threats, announced ... Conference 2009. The Company is scheduled to present on ... Imperial Room at the Grant Hyatt Hotel, New York City. ...
... NORTHRIDGE, Calif., Sept. 23 Today, Nature Made(R) announced the ... contest. Nature Made is the nation,s best-selling brand of vitamins, ... club channels. The company celebrates the inherent greatness found in ... to submit their personal stories of greatness as part of ...
... , - New Jersey Middle Schoolers Honored by ... - SDA, CDC Initiative Encourages Hygiene Education in Middle Schools , ... , WASHINGTON, Sept. 23 How do you teach hygiene in middle ... lab. A language arts class used the power of music. And students in ...
Cached Medicine News:Health News:Focused Learning Environment Guides Student Success 2Health News:Focused Learning Environment Guides Student Success 3Health News:American Lung Association of Ohio Encourages Cleveland Residents to See Themselves Among the Many 'Faces' of Influenza 2Health News:American Lung Association of Ohio Encourages Cleveland Residents to See Themselves Among the Many 'Faces' of Influenza 3Health News:American Lung Association of Ohio Encourages Cleveland Residents to See Themselves Among the Many 'Faces' of Influenza 4Health News:American Lung Association of Ohio Encourages Cleveland Residents to See Themselves Among the Many 'Faces' of Influenza 5Health News:National 'Greatness' Contest Winners Announced 2Health News:National 'Greatness' Contest Winners Announced 3Health News:'Bubble Trouble' Team Hits the Lab for Good Hygiene 2Health News:'Bubble Trouble' Team Hits the Lab for Good Hygiene 3Health News:'Bubble Trouble' Team Hits the Lab for Good Hygiene 4
... Instruments incorporate a layered design unique in ... monitored to prevent stray electrosurgical burns along ... insulation failure or capacitive coupling; a well-documented ... into all AEM Instruments provides a neutral ...
... 5mm AEM Laparoscopic Instruments incorporate a layered ... are shielded and monitored to prevent stray ... instrument caused by insulation failure or capacitive ... protective shield built into all AEM Instruments ...
... The 5mm AEM Laparoscopic Instruments incorporate a ... Instruments are shielded and monitored to prevent ... the instrument caused by insulation failure or ... The protective shield built into all AEM ...
... Instruments incorporate a layered design unique in ... monitored to prevent stray electrosurgical burns along ... insulation failure or capacitive coupling; a well-documented ... into all AEM Instruments provides a neutral ...
Medicine Products: