Navigation Links
Isis Reports Phase 2 Data on ISIS-APOCIII Rx Showing Significant Reductions of ApoC-III and Triglycerides in Patients With High Triglycerides Taking Fibrates
Date:7/22/2013

CARLSBAD, Calif., July 22, 2013 /PRNewswire/ -- Isis Pharmaceuticals, Inc. (NASDAQ: ISIS) announced data from a Phase 2 study of ISIS-APOCIIIRx in patients with high to severely high triglycerides on stable doses of fibrates.  In this study, patients treated with ISIS-APOCIIIRx experienced reductions of up to 70 percent in apolipoprotein C-III (apoC-III) and up to 64 percent in triglycerides.  In addition, patients treated with ISIS-APOCIIIRx experienced an up to 52 percent increase in high-density lipoprotein cholesterol (HDL-C), the 'good' cholesterol, and an up to 77 percent reduction in apoC-III-associated very low-density lipoprotein (VLDL) particles.  Isis is also evaluating ISIS-APOCIIIRx in this Phase 2 study as a monotherapy in patients with severely high triglycerides and plans to report these data at the European Society of Cardiology on August 31 in Amsterdam.

The Phase 2 study of ISIS-APOCIII­Rx was a double-blind, randomized, placebo-controlled 13-week study designed to assess the safety and activity of ISIS-APOCIIIRx.  The portion of the study reported today was conducted in patients with high to severely elevated triglyceride levels (between 225 and 2,000 mg/dL) on stable doses of fibrates. 

Table 1:  ISIS-APOCIIIRx Produced Statistically Significant Reductions of Triglycerides, ApoC-III and ApoC-III Associated VLDL in a Phase 2 Study in Patients With High Triglyceride Levels Treated With Stable Doses of Fibrates.  Mean % Changes From Baseline at Primary Endpoint.Placebo + Fibrate

(n=8)

ISIS-APOCIIIRx 200 mg + Fibrate 

(n=8)

ISIS-APOCIIIRx 300 mg + Fibrate

(n=10)ApoC-III

-2.2%

-59.4% (p<0.0001)


'/>"/>
SOURCE Isis Pharmaceuticals, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Qmed, the Leading Global MedTech Industry Resource, Partners with Clarimed, to Provide the Medical Manufacturing and Healthcare Industry with FDA Reports on Adverse Events
2. Sigma-Aldrich (NASDAQ: SIAL) Reports Q1 2012 Diluted EPS of $0.96, With Diluted Adjusted EPS of $0.99. Sales Increase 5% for Q1 2012. Full Year 2012 Diluted Adjusted EPS Outlook of $3.90 to $4.05 Reaffirmed.
3. Kelyniam Global Inc. Reports Record Cranial Implant Revenues in the 1st Quarter of 2012
4. Varian Medical Systems Reports Results for Second Quarter of Fiscal Year 2012
5. Mylan Reports Q1 2012 Adjusted Diluted EPS of $0.52, an 18% Increase Over Prior Year Quarter
6. CryoLife Reports Record Quarterly Revenues in First Quarter of 2012
7. PAREXEL Reports Third Quarter Fiscal Year 2012 Financial Results
8. Luminex Corporation Reports First Quarter 2012 Results
9. Hospira Reports First-Quarter 2012 Results
10. Endo Reports First Quarter Financial Results And Announces Return To Steady Supply Of OPANA® ER And Voltaren® Gel
11. The Female Health Company Reports Second Quarter Operating Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2014)... Aug. 19, 2014  Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) ... , Sanofi and Regeneron will host an IR Thematic ... Tuesday, September 2, 2014 , Baird 2014 Healthcare ... 3, 2014 , Citi,s 9 th Annual ... September 4, 2014 , Morgan Stanley Global Healthcare ...
(Date:8/19/2014)... Colo. , Aug. 19, 2014 ... Ampio Pharmaceuticals, Inc. (NYSE MKT: AMPE), ... rd Annual Meeting of the American Academy ... Acute Care Surgery in Philadelphia, Pennsylvania ... 2014.  The presentation will report results from a ...
(Date:8/19/2014)... August 19, 2014 According to ... (Neurosurgical Navigation Systems, ENT Navigation Systems and Orthopedic ... Trends and Forecast, 2014 - 2020", the global surgical ... in 2013 and is expected to grow at a ... an estimated value of USD 295.5 million in 2020. ...
Breaking Medicine Technology:Luoxis Announces Presentation of Positive Clinical Findings from Five-Year Clinical Study of Traumatic Brain Injury and Oxidation-Reduction Potential at 2014 American Academy of Surgical Trauma Meeting 2Luoxis Announces Presentation of Positive Clinical Findings from Five-Year Clinical Study of Traumatic Brain Injury and Oxidation-Reduction Potential at 2014 American Academy of Surgical Trauma Meeting 3Global Surgical Navigation Systems Market to Reach USD 295.5 Million in 2020 - Report by MarketResearchReports.biz 2Global Surgical Navigation Systems Market to Reach USD 295.5 Million in 2020 - Report by MarketResearchReports.biz 3Global Surgical Navigation Systems Market to Reach USD 295.5 Million in 2020 - Report by MarketResearchReports.biz 4Global Surgical Navigation Systems Market to Reach USD 295.5 Million in 2020 - Report by MarketResearchReports.biz 5Global Surgical Navigation Systems Market to Reach USD 295.5 Million in 2020 - Report by MarketResearchReports.biz 6Global Surgical Navigation Systems Market to Reach USD 295.5 Million in 2020 - Report by MarketResearchReports.biz 7Global Surgical Navigation Systems Market to Reach USD 295.5 Million in 2020 - Report by MarketResearchReports.biz 8Global Surgical Navigation Systems Market to Reach USD 295.5 Million in 2020 - Report by MarketResearchReports.biz 9
... China , July 9 /PRNewswire-Asia-FirstCall/ -- ... or the "Company"), a,developer, manufacturer and distributor of ... announced,that on July 8, 2010 , the ... Red Star Forest Bureau of Heilongjiang Province ...
... ATHENS, Greece , July 9 The companies ... and translator of the Greek language version of the GeneMedRx ... the program will include hundreds of drugs used exclusively in ... Greek language graphical user interface. Both the English and Greek ...
Cached Medicine Technology:Renhuang Signs Exclusive Purchase Agreement for Siberian Ginseng 2Renhuang Signs Exclusive Purchase Agreement for Siberian Ginseng 3Renhuang Signs Exclusive Purchase Agreement for Siberian Ginseng 4Medigene Appointed Exclusive Greek Licensee for GeneMedRx Personalized Prescribing Software 2
(Date:8/19/2014)... Skmen.com, an outstanding company in the garment industry, has unveiled ... addition to this, the company has also launched a big ... available at low rates, up to 30 percent off. ... beautiful bohemian outfits are available in many colours, including green, ... top quality clothes, reasonable prices and sincere service, the company ...
(Date:8/19/2014)... 2014 Recently, CanadaGooseJackor.nu, a popular supplier of ... Canada Goose Solaris Parkas . All clients that place ... discounted price (up to 35% off) before the end of ... in an online supplier’s business. CanadaGooseJackor.nu is a great platform ... all over the world can enjoy its dedicated professional service ...
(Date:8/19/2014)... LunaDress, a popular supplier of fashionable wedding, bridesmaid, ... now providing a discount of up to 67% on ... white prom outfits are available in different necklines; ladies ... , There are over 400 cheap white prom dresses ... offer is valid until August 29, 2014. The discounted ...
(Date:8/19/2014)... Recently, UWDress.com, a professional company of women’s dresses ... plus size formal evening dresses . Additionally, the firm has ... At the moment, all of them can be ordered at ... be valid until August 27, 2014. , The company ... designers believe that women of all shapes can be graceful ...
(Date:8/19/2014)... Recently, iFitDress.com,a leading online supplier of ... its new collection of pewter evening dresses . ... company’s global market. Each item is carefully made with ... spokesman, customers that have specific requirements can also order ... the brand new items are offered at discounted prices, ...
Breaking Medicine News(10 mins):Health News:2014 Bohemian Dresses Now for Sale at Skmen.com 2Health News:High Quality Canada Goose Solaris Parkas For Sale At CanadaGooseJackor.nu 2Health News:Popular Supplier LunaDress Providing an Exclusive Assortment of White Prom Dresses at a Discount of Up to 67% 2Health News:Cheap Plus Size Formal Evening Dresses Announced By UWDress.com 2Health News:Discounted Pewter Evening Dresses For 2014 Unveiled By Company iFitDress.com 2
... boost survival, German study shows , MONDAY, June ... performing radical hysterectomy in early-stage cervical cancer patients ... tumor recurrence, a German study shows. , The ... modified version of traditional radical hysterectomy. But this ...
... Plan Takes Holistic Approach in Seeking New Solutions to Improve ... Calif., June 1 More than 200 physicians and nurses ... to address a myriad of issues surrounding geriatric care in ... dementia and prostate cancer to more process-oriented issues such as ...
... 1, 2009) The latest advances in polyp detection, ... colonoscopy will be presented today at Digestive Disease Week ... size and type of polyps detected during colonoscopy and ... insight into the recommended frequency of follow-up preventive colonoscopy. ...
... heartbeat can indicate distress, but currently there is no ... when it could be too late to prevent serious ... system developed by an MIT scientist and colleagues including ... fetal heartbeat. The additional researchers are from the Institut ...
... , - John Hancock AnnuityNote Variable Annuity offers a simplified ... Market participation with downside protection , , - Simple ... John Hancock today announced the launch of a new retirement ... income to a broader market beyond the reach of traditional ...
... and the Alzheimer,s Association Support Award to Recognize Critical Role ... N.J., June 1 Eisai Inc., ... Alzheimer,s disease and their caregivers across America to nominate local ... A lzheimer,s. R ecognition of E xcellence.) Pharmacy ...
Cached Medicine News:Health News:Physicians Join With National Healthcare Leaders to Explore New Ways to Enhance Geriatric Care in America 2Health News:Physicians Join With National Healthcare Leaders to Explore New Ways to Enhance Geriatric Care in America 3Health News:New research identifies more effective tools for detection of colorectal cancer 2Health News:New research identifies more effective tools for detection of colorectal cancer 3Health News:New research identifies more effective tools for detection of colorectal cancer 4Health News:New research identifies more effective tools for detection of colorectal cancer 5Health News:New research identifies more effective tools for detection of colorectal cancer 6Health News:New research identifies more effective tools for detection of colorectal cancer 7Health News:MIT: New system monitors fetal heartbeat 2Health News:MIT: New system monitors fetal heartbeat 3Health News:John Hancock Launches New Retirement Income Solution 2Health News:John Hancock Launches New Retirement Income Solution 3Health News:John Hancock Launches New Retirement Income Solution 4Health News:John Hancock Launches New Retirement Income Solution 5Health News:Call for Nominations for the 2009 C.A.R.E. Pharmacy Award 2Health News:Call for Nominations for the 2009 C.A.R.E. Pharmacy Award 3
This apron was designed by Pulse Medical-RCI for optimal protection. Your comfort is also a primary concern so a wide support belt and shoulder pads are standard. When properly fitted, an overlapping...
... full protection is necessary, the Two-Piece ... add to your comfort through more ... greater flexibility. The vest comes with ... hanging loops as well as an ...
Quick Release buckle apron is user friendly with large support straps crisscrossing the back allowing proper placement of the belt at your waist....
... unique velcro design apron has ... support and comfort. Shoulder pads ... flaps aid in relieving weight ... fit is attained by varying ...
Medicine Products: