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Isis Reports New Data for Mipomersen in Routine High Cholesterol Patients and Provides Cumulative Safety Summary
Date:11/13/2007

- Patients on stable doses of statins treated for 3 months with 200 mg/week

mipomersen experienced 48% further reduction in LDL-cholesterol - Integrated Phase 1 & 2 safety update continues to support mipomersen's

favorable safety profile - Isis hosting Analyst & Investor Day today - webcast live at 9:00 a.m. EST

at http://www.isispharm.com

CARLSBAD, Calif., Nov. 13 /PRNewswire-FirstCall/ -- Isis Pharmaceuticals, Inc. (Nasdaq: ISIS) announced new results from its Phase 2 clinical trial of mipomersen (ISIS 301012) in patients with routine high cholesterol, as well as providing an integrated Phase 1 & Phase 2 safety summary for the drug. Data are being presented in conjunction with Isis' Analyst & Investor Day today in New York, which will be webcast live at 9:00 a.m. EST at http://www.isispharm.com.

Eight patients with routine high cholesterol on stable doses of less than or equal to 40 mg/day of statins were treated with 200 mg/week mipomersen for three months. Results were compared with those from 14 placebo-treated patients. All patients remained on stable statin therapy throughout the study. Mipomersen treatment resulted in a 42% reduction in apoB and a 48% reduction in LDL-C, beyond reductions achieved with statin therapy alone. Previously, Isis reported results from the dose escalation portion of the study. With five weeks of treatment at 200 mg/week reductions in apoB and LDL-C were 24% and 30% respectively, so, as predicted, extending treatment with mipomersen from five weeks to 13 weeks led to further reductions in apoB and LDL-C. Mipo
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SOURCE Isis Pharmaceuticals, Inc.
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