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Isis Reports Financial Results and Highlights for Third Quarter 2011
Date:11/7/2011

orma operating expenses and pro forma loss from operations were adjusted from GAAP to exclude compensation expense related to stock options, which are non-cash.  Isis has regularly reported non-GAAP measures for operating expenses and loss from operations as pro forma results.  These measures are provided as supplementary information and are not a substitute for financial measures calculated in accordance with GAAP.  Isis reports these pro forma results to better enable financial statement users to assess and compare its historical performance and project its future operating results and cash flows.  Further, the presentation of Isis' pro forma results is consistent with how Isis' management internally evaluates the performance of its operations. Isis Pharmaceuticals, Inc.Condensed Consolidated Balance Sheets(In Thousands)September 30,December 31,20112010(unaudited)Assets:  Cash, cash equivalents and short-term investments$364,763$472,353  Other current assets12,32610,784  Property, plant and equipment, net98,01935,703  Other assets30,67731,637Total assets$505,785$550,477Liabilities and stockholders' equity:  Other current liabilities$31,114$31,388  Current portion of deferred contract revenue52,42874,502  2 5/8% convertible subordinated notes139,239132,895  Long-term obligations, less current portion73,61915,867  Investment in Regulus Therapeutics Inc.3,145870  Long-term deferred contract revenue19,41550,413  Stockholders' equity186,825244,542Total liabilities and stockholders' equity$505,785$550,477
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