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Isis Reports Financial Results and Highlights for Third Quarter 2010
Date:11/4/2010

se in placebo.
  • In both studies, frequently observed adverse events were injection site reactions and flu-like symptoms. Elevations in liver transaminases were observed that were generally similar in character with those seen in other studies.
  • Isis added to its pipeline ISIS-GSK1Rx, the first drug selected as part of its collaboration with GSK to treat severe and rare diseases.
  • Isis' partners continued to advance the drugs in Isis' pipeline with the initiation of two Phase 3 studies for OGX-011, and a Phase 2 study for OGX-427 in patients with cancer.
  • Isis benefits financially as the drugs in its pipeline advance in development earning $13 million in milestone payments this year, including a $5 million milestone payment from GSK for the identification of ISIS-GSK1Rx as a development candidate.
  • Isis' partner, Excaliard, reported positive Phase 2 data demonstrating that treatment with EXC 001 reduced scarring in patients following elective surgery.  
  • Sanofi-aventis invested $10 million in Regulus acquiring less than 10% ownership of the preferred outstanding shares.  The remaining preferred outstanding shares are owned by Alnylam Pharmaceuticals and Isis.

  • Conference CallAt 4:30 p.m. Eastern Time today, November 4, Isis will conduct a live webcast conference call to discuss this earnings release and related activities.  Interested parties may listen to the call by dialing 866-804-6924 and refer to passcode "ISIS 2010," or access the webcast at www.isispharm.com.  A webcast replay will be available for a limited time at the same address.

    About Isis Pharmaceuticals, Inc.Isis is exploiting its expertise in RNA to discover and develop novel drugs for its product pipeline and for its partners.  The Company has successfully commercialized the world's first antisense drug and has 22 drugs in development.  Isis' drug developm
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    SOURCE Isis Pharmaceuticals, Inc.
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