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Isis Reports Financial Results and Highlights for Second Quarter 2013
Date:8/6/2013

study treated patients also experienced improvements in glucose control and trends toward enhanced insulin sensitivity.
  • Isis reported Phase 2 data on ISIS-CRPRx in patients with rheumatoid arthritis (RA).  In this study, patients treated with ISIS-CRPRx achieved rapid, dose-dependent mean reductions of up to 67 percent in CRP, but failed to demonstrate improvements in signs and symptoms of RA that were sufficiently better than those achieved by patients in the placebo group to justify further development of ISIS-CRPRx for RA.
  • Dr. David Hong reported Phase 1 data on ISIS-STAT3Rx at the American Society of Clinical Oncology.  In this study, treatment with ISIS-STAT3Rx resulted in partial responses that were durable and prolonged in two out of three patients with diffuse large B-cell lymphoma who were refractory to prior chemotherapy treatments.
  • Isis and its partners initiated clinical studies on three drugs in Isis' pipeline.
  • Isis initiated a Phase 2 study of ISIS-SMN­­Rx in infants with SMA and earned a $3.5 million milestone payment from Biogen Idec.
  • AstraZeneca initiated a Phase 1b/2a study of ISIS-STAT3Rx in patients with advanced metastatic hepatocellular carcinoma.
  • Isis initiated a Phase 1 study of ISIS-APOARx, an antisense drug designed to reduce levels of Lp(a), an atherogenic lipoprotein.
  • Isis and its partners continued to advance Isis' preclinical stage pipeline by adding three drugs into development.
  • AstraZeneca selected ISIS-ARRx as the second development candidate to advance into development under its collaboration with Isis.  As a result, Isis earned a $10 million milestone payment from AstraZeneca.
  • Xenon selected XEN701 as a development candidate and licensed XEN701 from Isis.  As a result, Isis earned $3.5 million from Xenon.
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  • SOURCE Isis Pharmaceuticals, Inc.
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