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Isis Reports Financial Results and Highlights for Second Quarter 2013
Date:8/6/2013

c and diluted net loss per share for the three and six months ended June 30, 2013 was $0.09 per share and $0.11 per share, respectively, compared to $0.01 per share and $0.25 per share for the same periods in 2012. Isis' net loss for the six months ended June 30, 2013 was significantly lower than in 2012 primarily due to the revenue Isis earned from its partners in the first half of 2013.

Balance Sheet
As of June 30, 2013, Isis had cash, cash equivalents and short-term investments of $590.8 million compared to $374.4 million at December 31, 2012 and working capital of $582.1 million at June 30, 2013 compared to $349.1 million at December 31, 2012.  The Company received a substantial amount of cash in the first six months of 2013, including $210 million from the issuance of its common stock and $93 million in payments from its partners.  Isis' working capital increased in 2013 primarily due to the increase in cash and the increase in the value of Isis' ownership in Regulus.  At June 30, 2013, the carrying value of Isis' investment in Regulus increased to $62.2 million compared to $33.6 million at December 31, 2012.  This increase demonstrates the value that Isis is realizing from its satellite company strategy.

Business Highlights
"Our innovative business strategy provides us with multiple opportunities to create and maintain value.  We design our drug development activities to demonstrate the broad therapeutic profile of each drug.  In this way, we strive to maximize the value of each drug.  For example, ISIS-APOCIIIRx is an antisense drug we discovered and are developing to treat patients with severely high triglycerides.  Because of our clinical experience with KYNAMRO, our strong internal development capabilities and the manageable size of the clinical program required for our initial indication, we believe we can successfully develop ISIS-APOCIIIRx on our own without a partn
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SOURCE Isis Pharmaceuticals, Inc.
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