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Isis Reports Financial Results and Highlights for First Quarter 2013
Date:5/7/2013

nt revenue under collaborative agreements$41,921$21,818Licensing and royalty revenue1,4391,417Total revenue43,36023,235Expenses:Research and development38,31238,714General and administrative3,4232,976Total operating expenses41,73541,690Income (loss) from operations1,625(18,455)Other income (expense):Equity in net loss of Regulus Therapeutics Inc.-(976)Investment income376600Interest expense(4,795)(5,179)Gain on investments, net1,05817Loss before income tax expense$(1,736)$(23,993)Income tax benefit (expense)64(2)Net loss$(1,672)$(23,995)Basic and diluted net loss per share$(0.02)$(0.24)Shares used in computing basic and diluted net loss per share101,875100,157 Isis Pharmaceuticals, IncReconciliation of GAAP to Pro Forma Basis: Condensed Consolidated Operating Expenses, (Income) Loss From Operations, and Net Income (Loss)(In Thousands)Three months ended,

March 31,20132012(unaudited)As reported operating expenses according to GAAP$41,735$41,690Excluding compensation expense related to equity awards

(2,869)(2,267)Pro forma operating expenses$38,866$39,423As reported income (loss) from operations according to GAAP$1,625$(18,455)Excluding compensation expense related to equity awards

(2,869)(2,267)Pro forma income (loss) from operations$4,494$(16,188)As reported net loss according to GAAP$(1,672)$(23,995)Excluding compensation expense related to equity awards

(2,869)(2,267)Pro forma net income (loss)$1,197$(21,728) Reconciliation of GAAP to Pro Forma BasisAs illustrated in the Selected Financial Information in this press release, pro forma operating expenses, pro forma income (loss) from operations, and proforma net income (loss) were adjusted from GAAP to exclude compensation expense related to equity awards, which are non-cash.  Isis has regularly reported non-GAAP measures for operating results as pro forma results.  These measures are provided as supplementary information and are not a substitute for fin
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SOURCE Isis Pharmaceuticals, Inc.
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