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Isis Reports Financial Results and Highlights for First Quarter 2013
Date:5/7/2013

  • Dr. Claudia Chiriboga reported Phase 1 data on ISIS-SMNRx at the American Academy of Neurology.  In this open-label study conducted in a small population, ISIS-SMNRx was well tolerated in children with spinal muscular atrophy (SMA) and functional activity improvements  in muscle function were observed in a number of these children.
  • Isis reported positive Phase 1 data on ISIS-CRPRx demonstrating that, in healthy volunteers, ISIS-CRPRx can selectively blunt severe increases in CRP following an endotoxin challenge, which produces immune responses similar to those seen with bacterial infections.
  • Isis published data in the journal Circulation Research demonstrating that antisense inhibition of ApoC-III produced significant reductions of ApoC-III and triglycerides in multiple species including man.  Isis presented these data in an oral presentation at the 2013 Duell Meeting in March 2013.
  • Isis continued to advance its pipeline by initiating clinical studies in numerous disease areas.
  • Isis initiated a Phase 2 study of ISIS-SMN­­Rx in infants with SMA and will earn a $3.5 million milestone payment from Biogen Idec when the first patient is dosed in this study.
  • Isis initiated a Phase 2/3 study of ISIS-TTR­­Rx in patients with familial polyneuropathy and received a $7.5 million milestone payment from GlaxoSmithKline related to the initiation of this study.
  • AstraZeneca initiated a Phase 1b/2a study of ISIS-STAT3Rx in patients with advanced metastatic hepatocellular carcinoma.
  • Isis initiated a Phase 1 study of ISIS-APOARx, an antisense drug designed to reduce levels of Lp(a), an atherogenic lipoprotein.
  • Isis formed a new alliance with Roche to discover and develop antisense drugs to treat Huntington's disease.
  • Isis received a $30 million upfront payment and is elig
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  • SOURCE Isis Pharmaceuticals, Inc.
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