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Isis Reports Financial Results and Highlights for First Quarter 2013
Date:5/7/2013

months ended March 31, 2013 was $43.4 million compared to $23.2 million for the same period in 2012.  Isis' revenue fluctuates based on the nature and timing of payments under agreements with Isis' partners, including license fees, milestone-related payments and other payments. For example, Isis' revenue in the first quarter of 2013 was significantly higher than in the first quarter of 2012 primarily as a result of the $25 million milestone payment from Genzyme for FDA approval of the KYNAMRO NDA and the $7.5 million milestone payment from GSK for the initiation of the Phase 2/3 study of ISIS-TTRRx.  Also in the first quarter of 2013, Isis began amortizing revenue from its new alliance with AstraZeneca and its third collaboration with Biogen Idec.  Isis' increase in revenue was offset, in part, by the completion of the amortization of the upfront payments associated with Isis' Genzyme collaboration. 

Operating ExpensesOn a pro forma basis, Isis' operating expenses for the three months ended March 31, 2013 of $38.9 million were essentially flat compared to $39.4 million for the same period in 2012. 

On a GAAP basis, Isis' operating expenses for the three months ended March 31, 2013 and 2012 were $41.7 million.Gain on InvestmentsIsis' gain on investments for the three months ended March 31, 2013 was due to the $1.1 million Isis realized when it sold the stock it held in Sarepta Therapeutics. This gain demonstrates the value that Isis is realizing from its satellite company strategy.Net LossIsis reported a net loss of $1.7 million for the three months ended March 31, 2013 compared to $24.0 million for the same period in 2012.  Basic and diluted net loss per share for the three months ended March 31, 2013 was $0.02 per share compared to $0.24 per share for the same period in 2012. Isis' net loss was significantly lower than in 2012 primarily due to the milestone payments it received from
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SOURCE Isis Pharmaceuticals, Inc.
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