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Isis Reports Financial Results and Highlights for First Quarter 2013
Date:5/7/2013

ancial measures calculated in accordance with GAAP.  Isis reports these pro forma results to better enable financial statement users to assess and compare its historical performance and project its future operating results and cash flows.  Further, the presentation of Isis' pro forma results is consistent with how Isis' management internally evaluates the performance of its operations.  Isis Pharmaceuticals, Inc.Condensed Consolidated Balance Sheets(In Thousands)March 31,December 31,20132012(unaudited)Assets:  Cash, cash equivalents and short-term investments$371,911$374,446  Investment in Regulus Therapeutics Inc.44,86333,622  Other current assets15,05515,370  Property, plant and equipment, net89,69491,084  Other assets31,43831,164Total assets$552,961$545,686Liabilities and stockholders' equity:  Other current liabilities$35,051$38,397  Current portion of deferred contract revenue35,24435,925  2 3/4% convertible senior notes145,533143,990  Long-term obligations, less current portion77,22677,952  Long-term deferred contract revenue58,81666,656  Stockholders' equity201,091182,766Total liabilities and stockholders' equity$552,961$545,686
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