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Isis Reports Financial Results and Highlights for First Quarter 2012
Date:5/8/2012

$20,014Licensing and royalty revenue1,4171,133Total revenue23,23521,147Expenses:Research and development38,71434,245General and administrative2,9763,010Total operating expenses41,69037,255Loss from operations(18,455)(16,108)Other income (expense):Equity in net loss of Regulus Therapeutics Inc.(976)(856)Investment income600705Interest expense(5,179)(3,415)Gain (loss) on investments, net17(318)Loss before income tax expense$(23,993)$(19,992)Income tax expense(2)(2)Net loss$(23,995)$(19,994)Basic and diluted net loss$(0.24)$(0.20)Shares used in computing basic and diluted net loss per share100,15799,569Isis Pharmaceuticals, Inc.Reconciliation of GAAP to Pro Forma Basis:  Condensed Consolidated Operating Expenses and Loss From Operations (In Thousands)Three months ended,

March 31,20122011(unaudited)As reported operating expenses according to GAAP$41,690$37,255Excluding compensation expense related to equity awards(2,267)(2,732)Pro forma operating expenses$39,423$34,523As reported loss from operations according to GAAP$(18,455)$(16,108)Excluding compensation expense related to equity awards(2,267)(2,732)Pro forma loss from operations$(16,188)$(13,376)Reconciliation of GAAP to Pro Forma Basis
As illustrated in the Selected Financial Information in this press release, pro forma operating expenses and pro forma loss from operations were adjusted from GAAP to exclude compensation expense related to equity awards, which are non-cash.  Isis has regularly reported non-GAAP measures for operating expenses and loss from operations as pro forma results.  These measures are provided as supplementary information and are not a substitute for financial measures calculated in accordance with GAAP.  Isis reports these pro forma results to better enable financial statement users to assess and compare its historical performance and project its future operating results and cash flows.  Further, the presentation of Isis' pro forma results is consi
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SOURCE Isis Pharmaceuticals, Inc.
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