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Isis Reports Financial Results and Highlights for First Quarter 2012
Date:5/8/2012

, and are designed to provide long-term control in patients who cannot control their glucose levels with existing therapies.  With type 2 diabetes being the most rapidly growing epidemic worldwide, we believe bringing forward novel medicines to add to the treatment paradigm for these patients is a wise investment," continued Ms. Parshall.  

"In summary, we have begun another productive year in which we expect to report data on many of the drugs in our pipeline, initiate larger, longer studies for our Factor XI and TTR drugs, and continue to move promising new drugs into our pipeline.
We look forward to KYNAMRO commercialization and bringing this important new medicine to patients in great need," concluded Ms. Parshall. 

Corporate and Drug Development Highlights

  • Genzyme submitted a new drug application for KYNAMRO in the United States for homozygous FH patients.
  • Dr. Raul Santos presented data from the long-term extension study of KYNAMRO at the International Symposium on Atherosclerosis.  The data highlight the long-term safety and efficacy of KYNAMRO in patients who have been treated with KYNAMRO.
  • Isis initiated a Phase 2 study on ISIS-APOCIIIRx in patients with elevated triglycerides and a Phase 1 study on ISIS-STAT3Rx in patients with cancer.
  • Isis reported data from a Phase 1 study of ISIS-TTRRx showing that ISIS-TTRRx produced statistically significant reductions in TTR protein.
  • Isis formed a new strategic alliance with Biogen Idec to develop and commercialize ISIS-SMNRx to treat Spinal Muscular Atrophy (SMA).  Isis received a $29 million upfront payment and is eligible to receive up to an additional $270 million in a license fee and milestone payments, and double-digit royalties on sales of ISIS-SMNRx.
  • Isis received Orphan Drug Designation for ISIS-SMNRx in Europe for the treatment of SMA.
  • OncoGenex reported preliminary positive Phase 1 d
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