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Isis Reports Financial Results and Highlights for First Quarter 2012
Date:5/8/2012

ance for the NDA submission of KYNAMRO for patients with homozygous FH.
  • Initiate a clinical study of ISIS-TTRRx in patients with Familial Amyloid Polyneuropathy.
  • Financial Results
    On a GAAP basis, Isis reported a loss from operations of $18.5 million for the three months ended March 31, 2012, compared to $16.1 million for the same period in 2011.

    All pro forma amounts referred to in this press release exclude non-cash stock compensation.  Please refer to the reconciliation of pro forma and GAAP measures, which is provided later in this release.

    Revenue
    Revenue for the three months ended March 31, 2012 was $23.2 million, compared to $21.1 million for the same period in 2011.  Isis' revenue fluctuates based on the nature and timing of payments under agreements with the Company's partners, including license fees, milestone-related payments and other payments. Isis earned new revenue in the first quarter of 2012 from the $29 million upfront fee it received from its new partner, Biogen Idec, which the Company is amortizing over four years. 

    Operating Expenses
    On a pro forma basis, operating expenses for the three months ended March 31, 2012 were $39.4 million, compared to $34.5 million for the same period in 2011.  Isis' operating expenses in the first three months of 2012 reflected higher development costs associated with Isis' maturing pipeline of drugs offset by lower development expenses related to KYNAMRO because Isis is sharing these expenses equally with Genzyme until KYNAMRO is profitable.  Genzyme is paying all of the marketing and selling expenses until KYNAMRO is profitable. 

    On a GAAP basis, Isis' operating expenses for the three months ended March 31, 2012 were $41.7 million, compared to $37.3 million for the same period in 2011.Net Loss
    Isis reported a net loss of $24.0 million for the three months ended March 31, 2012, c
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    SOURCE Isis Pharmaceuticals, Inc.
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