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Isis Reports Financial Results and Highlights for 2012
Date:2/28/2013

Rx Phase 2/3 study.
  • Isis benefited as its partners advanced RNA-based technologies and products incorporating its technology.
  • Isis received $2.7 million from Alnylam as a result of Alnylam's licenses that included Isis' patents.
  • Isis received $1.3 million from Pfizer triggered by Pfizer's decision to advance EXC 001 into a Phase 2 study. 
  • Regulus Therapeutics completed an initial public offering and is now traded on The NASDAQ Global Market under the ticker RGLS.  Isis purchased $3 million of Regulus' common stock at the offering price and remains a significant shareholder with approximately 17% ownership on a fully diluted basis, which is valued at approximately $36 million.
  • Isis completed a successful $201.3 million convertible debt financing.  Isis used the majority of the proceeds of this financing to redeem its outstanding $162.5 million 2 ⅝% subordinated convertible debt. 
  • The securities class action lawsuit was voluntarily withdrawn and there are no pending lawsuits related to any violation of securities laws.
  • Isis and its collaborators published papers in leading scientific journals demonstrating the broad applicability of its technologies.
  • A paper in Nature demonstrating that an antisense compound selectively and rapidly reduced target RNA in skeletal muscle and alleviated disease in animal models of myotonic dystrophy.
  • A paper in Neuron demonstrating that an antisense compound reversed disease in animal models of Huntington's disease.
  • Two papers in the journal Cell demonstrating that single-stranded RNA-like antisense technology can activate the RNAi pathway and inhibit the expression of targeted genes.
  • Conference Call
    At 12:00 p.m. Eastern Time today, February 28, 2013, Isis will conduct a live webcast conference call to discuss this earnings release and related activities.  Interested parties may listen
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    SOURCE Isis Pharmaceuticals, Inc.
    Copyright©2012 PR Newswire.
    All rights reserved

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