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Isis Publishes Data Demonstrating Antisense Targeting of ApoC-III Significantly Reduces ApoC-III and Triglycerides
Date:4/1/2013

d elevated apoC-III.   Following the completion of the Phase 2 study, we plan to move rapidly into a Phase 3 study in the most severe patients with triglyceride levels greater than 880 mg/dL who are unable to reach acceptable triglyceride levels with currently available treatments."

In the published data, treatment with an antisense compound targeting apoC-III produced a variety of potential cardio-protective effects including significant dose-dependent reductions of apoC-III and triglycerides in all models and species, including man.  In addition, treatment with an antisense compound targeting apoC-III resulted in enhanced triglyceride clearance from blood following a high-fat meal, reduction of VLDL particles and a slight increase in HDL-C levels.  In all models and in the Phase 1 study, antisense inhibition of apoC-III was well tolerated.  These data were consistent across multiple preclinical models and species and in a Phase 1 study in healthy volunteers demonstrating that Isis' antisense technology was able to produce predictable and consistent responses among different animal models that translate into corresponding activity in man. In the Phase 1 study, treatment with ISIS-APOCIIIRx was well tolerated and produced rapid, dose-dependent median reductions of up to 44 percent in plasma triglycerides and up to 78 percent in apoC-III protein, with two out of the three subjects in the highest dose group achieving undetectable levels of apoC-III. 

ABOUT ISIS-APOCIIIRx
ISIS-APOCIIIRx inhibits the production of apoC-III, a traditionally 'undruggable' target that inhibits the clearance of triglycerides from the blood. People who do not produce apoC-III have lower levels of triglycerides and lower instances of cardiovascular disease. ApoC-III is elevated in patients with dyslipidemia, or an abnormal concentration of lipids in the blood, and is frequently associated with multiple metabolic
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SOURCE Isis Pharmaceuticals Inc.
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