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Isis Publishes Data Demonstrating Antisense Targeting of ApoC-III Significantly Reduces ApoC-III and Triglycerides
Date:4/1/2013

CARLSBAD, Calif., April 1, 2013 /PRNewswire/ -- Isis Pharmaceuticals, Inc. (NASDAQ: ISIS) announced today the publication of new data in the journal Circulation Research [doi:10.1161/CIRCRESAHA.111.300367] demonstrating that antisense targeting of apolipoprotein C-III (apoC-III) resulted in significant reductions in apoC-III and triglycerides, each an independent risk factor for cardiovascular disease.  Hypertriglyceridemia is a serious medical condition associated with premature coronary artery disease and an increased risk for pancreatitis.  Isis is developing its antisense apoC-III inhibitor, ISIS-APOCIIIRx, for the treatment of patients with severe hypertriglyceridemia and plans to report top-line data in the middle of this year. 

"Patients with high triglycerides and high apoC-III levels are at significant risk of developing cardiovascular disease, metabolic syndrome, diabetes and pancreatitis.  Despite currently available triglyceride-lowering agents, many patients cannot reduce their triglycerides to acceptable levels.  Because apoC-III is a key regulator of triglyceride clearance from the blood and itself is an independent risk factor for cardiovascular disease, lowering both apoC-III and triglycerides could provide significant therapeutic benefit," said Richard Geary , Ph.D., senior vice president of development at Isis.  "In this paper, we report consistent activity of antisense inhibition of apoC-III to lower both apoC-III and triglycerides in multiple rodent models of dyslipidemia, in non-human primates and in man.  These data support the potential therapeutic benefit a selective apoC-III inhibitor could offer patients with hypertriglyceridemia an
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SOURCE Isis Pharmaceuticals Inc.
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