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Isis Pharmaceuticals to receive $1.4 million from Alnylam
Date:8/28/2012

CARLSBAD, Calif., Aug. 28, 2012 /PRNewswire/ -- Isis Pharmaceuticals, Inc. (NASDAQ: ISIS) announced today that it will receive $1.4 million from Alnylam Pharmaceuticals, Inc. (NASDAQ: ALNY) as its portion of the upfront fees in Alnylam's recently announced collaboration in the field of agriculture.  In addition, Isis has the potential to receive royalty payments and a portion of future milestone payments.  This transaction further emphasizes the value of Isis' innovation and the leadership role Isis has played in the field of RNA-based technology.

Isis is the leading company in RNA-based technology and owns or controls more than 1,500 issued patents.  As such, Isis holds patents for numerous applications of antisense technology, including RNAi, and for novel targets, such as microRNAs being developed by Regulus, which is co-owned by Isis and Alnylam.  In 2004, Isis and Alnylam entered into a strategic relationship in which Alnylam obtained an exclusive license to Isis' intellectual property for double-stranded oligonucleotide therapeutics that mediate RNAi.  In return, Isis received an upfront payment and financial participation in future transactions supported by Isis' patents.

"Our innovations and discoveries related to RNA-based technologies have resulted in a broad and valuable patent estate.  Our business strategy is focused on maximizing the value of these innovations by providing partners access to our technology for uses that are outside of our area of focus.  The benefit of this strategy is evident in the success of the strategic relationships we establish, such as the one we have with Alnylam," said B. Lynne Parshall, Chief Operating Officer and CFO of Isis.

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