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Isis Pharmaceuticals Reports That Its Selective CRP Inhibitor Demonstrated Activity in a Phase 1 Study
Date:2/23/2011

ts with elevated levels of CRP.  The subjects enrolled in this cohort had an average CRP level at baseline of approximately 3.0 mg/L.  After only three weeks of dosing, the six subjects who received ISIS-CRPRx had an average CRP level of 0.76 mg/L, which is within the normal range of CRP and represents an average reduction of greater than 70 percent compared to placebo.  Subjects receiving placebo remained elevated above 3.0 mg/L.  In all subjects receiving the drug, it was well tolerated with no serious adverse events.    

"This is the first study evaluating the activity of a selective CRP inhibitor, and we are extremely pleased with the activity and safety of ISIS-CRPRx.  Based on the substantial reductions in CRP that we observed in the cohort of subjects who had elevated levels of CRP, we expect to see CRP reductions at much lower doses in our Phase 2 studies.  In these studies, we will evaluate ISIS-CRPRx in patients with elevated CRP levels in a variety of diseases, including multiple myeloma and rheumatoid arthritis.  The results from these initial studies will help us inform the rest of our Phase 2 development program for CRP, in which we will expand into other disease areas," commented Richard Geary, Ph.D., Senior Vice President of Development at Isis.  "Chronically elevated levels of CRP have been linked to cardiovascular disease and associated with a worsening of overall outcome in conditions such as end-stage renal disease, suggesting that lowering CRP in these patients could be beneficial."  

ABOUT ISIS PHARMACEUTICALS, INC.

Isis is exploiting its expertise in RNA to discover and develop novel drugs for its product pipeline and for its partners.  The Company has successfully commercialized the world's first antisense drug and has 24 drugs in development.  Isis' drug development programs are focused on treating cardiovascular, metabolic, and severe neurodegenerat
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SOURCE Isis Pharmaceuticals, Inc.
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