Navigation Links
Isis Pharmaceuticals Reports That Its Selective CRP Inhibitor Demonstrated Activity in a Phase 1 Study
Date:2/23/2011

CARLSBAD, Calif., Feb. 23, 2011 /PRNewswire/ -- Isis Pharmaceuticals, Inc. (Nasdaq: ISIS) announced today the results from a Phase 1 clinical trial in which ISIS-CRPRx produced statistically significant reductions in C-reactive protein (CRP) in the cohort of subjects in the study with elevated CRP.  In this study, ISIS-CRPRx was well tolerated at doses up to 600 mg/week.  Isis plans to evaluate ISIS-CRPRx in Phase 2 studies in indications that could provide early proof-of-concept in diseases with elevated CRP.  Isis plans to initially evaluate ISIS-CRPRx in multiple myeloma and rheumatoid arthritis, before expanding into cardiovascular and other diseases.  

"CRP levels are increased in many inflammatory disorders, and excessive amounts of CRP have been linked to multiple clinical conditions, including cardiovascular disease and diabetes," said Paul M. Ridker, M.D., Eugene Braunwald Professor of Medicine at the Brigham and Women's Hospital and Harvard Medical School.  "This is the first evaluation of a selective CRP inhibitor and the first such drug shown to be active in man. What this new agent thus provides is a method to directly test whether or not lowering CRP per se might be beneficial for patient care, something that could not be addressed in the past."

The Phase 1 study of ISIS-CRPRx was a blinded, randomized, placebo-controlled, dose-escalation study designed to assess the safety and pharmacokinetic profile of ISIS-CRPRx as well as to assess the initial effects of the drug on baseline CRP levels.  ISIS-CRPRx was evaluated in single and multiple doses ranging from 50 mg per week to 600 mg per week in 80 healthy volunteers.  In all but one cohort, Isis enrolled subjects who had normal (generally undetectable to less than 2 mg/L) CRP levels.  In the 600 mg per week multi-dose cohort, Isis enrolled eight subjec
'/>"/>

SOURCE Isis Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4

Related medicine technology :

1. Auxilium Pharmaceuticals, Inc. Receives Clearance to Resume Clinical Trials for XIAFLEX(TM)
2. Vion Pharmaceuticals Completes Accrual of 85 Patients to its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Elderly AML
3. Solvay Pharmaceuticals, Inc. and Wyeth Pharmaceuticals Announce Receipt of an FDA Action Letter for Bifeprunox, an Investigational Treatment for Schizophrenia
4. Callisto Pharmaceuticals Opens Additional Sites for Phase II Clinical Trial of Atiprimod in Advanced Carcinoid Cancer Patients
5. WallSt.net (www.wallst.net) Updates the Investment Community Through an All-New Interview With RegeneRx Biopharmaceuticals CEO
6. Quark Pharmaceuticals, Inc. Presented Positive Preclinical Results of Systemic RNAi Compound for Acute Renal Failure (ARF)
7. Peregrine Pharmaceuticals Doses First Patient in Cotara(R) Phase II Brain Cancer Trial In India
8. Nabi Biopharmaceuticals Announces Second Quarter 2007 Financial Results
9. Access Pharmaceuticals Provides Update on Clinical Development Plan of ProLindac
10. Quark Pharmaceuticals Extends Research Agreement with State University of New York for Proprietary siRNA Compounds for Acute Hearing Loss
11. Acura Pharmaceuticals, Inc. Secures Financing to Fund Pivotal Phase III Clinical Trial for Lead Aversion(R) Technology Product Candidate
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2013)... CHAPEL HILL, N.C. , May 24, 2013 ... Affairs to the forefront of many organizations, priority ... biopharmaceutical and medical device sectors understand a strong ... meeting current challenges in clinical development, market ... operate effectively to create a vital bridge between ...
(Date:5/24/2013)... -- BD (Becton, Dickinson and Company) (NYSE: BDX ), ... will present at the Deutsche Bank 38 th Annual ... a.m. (ET). A live webcast of BD,s ... www.bd.com/investors and will be available for replay through ... BD is a leading global medical technology company that ...
(Date:5/24/2013)... BEVERLY HILLS, Calif. , May 24, 2013 /PRNewswire-iReach/ ... the state,s leading non-profit substance abuse services organization, is ... at the Beverly Hills Hotel on June 6, 2013.  ... event to raise funds for the adolescent residential treatment ... as well as honor individuals whose accomplishments have positive ...
Breaking Medicine Technology:Building Medical Affairs Capabilities to Ensure Organizational Success across Key Operational Areas 2Phoenix House Honors Allergan Chairman David Pyott And Legendary Sports Agent And Humanitarian, Leigh Steinberg 2Phoenix House Honors Allergan Chairman David Pyott And Legendary Sports Agent And Humanitarian, Leigh Steinberg 3
(Date:5/24/2013)... Angeles, CA (PRWEB) May 24, 2013 ... to present the 3rd Annual EB-5 Investment Summit: Dealmakers ... The Dealmakers Conference will focus on exploring alternative finance ... the latest market, legal and economic information, and updates ... professionals within the EB-5 industry. , "Our goal ...
(Date:5/24/2013)... Stoler believes that there is much to be learned ... That’s why he hosts “Building New York—New York ... that’s why he invited Robert Glazer, Chief Executive Officer ... specialty practice in the greater New York area, whose ... sub-specialists service communities throughout New York and New Jersey ...
(Date:5/24/2013)... to the National Institutes of Health, Stevens Johnson Syndrome (SJS) ... the skin and mucous membranes. SJS occurs most commonly ... (i). In the early stages SJS presents flu-like symptoms, ... it affects the mucous membranes such as the eyes, mouth ... eye causes conjunctivitis (pink eye). Inflammation of the mouth ...
(Date:5/24/2013)... New York (PRWEB) May 24, 2013 ... Mobility® is a leading nationwide sales, installation ... for both consumer and commercial applications. The company’s ... platform lifts, vehicle lifts for mobility devices, pool ... others. 101 Mobility operates over 30 locations, primarily ...
(Date:5/24/2013)... The SunglassFIX Photo Contest lets ... while learning how to make their sunglasses, and ... only need to upload pictures of themselves, friends ... Sunglass Fix on Facebook in order to enter. ... lens replacement online store . , ...
Breaking Medicine News(10 mins):Health News:Brian Su Organizes 3rd Annual EB-5 Investment Conference in Long Beach, California 2Health News:Robert Glazer, Chief Executive Officer of ENT and Allergy Associates, LLP®, Talks About the Business of Succeeding in New York 2Health News:Robert Glazer, Chief Executive Officer of ENT and Allergy Associates, LLP®, Talks About the Business of Succeeding in New York 3Health News:Robert Glazer, Chief Executive Officer of ENT and Allergy Associates, LLP®, Talks About the Business of Succeeding in New York 4Health News:Personal Injury Law Firm Issues New Infographic Detailing a Potential Link Between Stevens Johnson Syndrome and Common Children’s Medicines 2Health News:Personal Injury Law Firm Issues New Infographic Detailing a Potential Link Between Stevens Johnson Syndrome and Common Children’s Medicines 3Health News:Cortec Closes Equity Transaction with 101 Mobility 2Health News:Break the Sunglass Mold – Reuse 'Em, Don’t Toss 'Em then Enter the SunglassFIX Photo Contest to Win 2
... Society for Radiation Oncology (ASTRO) will host four news briefings ... from its 51st Annual Meeting. News ... 8:00 a.m. (Central); 9:00 a.m. (Eastern) What: ... Study findings previewed:, Four months hormone therapy added ...
... While ... very few are concerned about the best method to dry their hands. This is why ... the flu, to inform the Canadian population of the undeniable advantages of paper hand towels. ... Candiac, Quebec (PRWEB) October ...
... and ST. PAUL, Minn., Oct. 29 Children,s Hospitals and ... to serve as Director of Child Health Policy and Advocacy. ... of health policy experience in Minnesota and is recognized as ... state legislature. , (Photo: http://www.newscom.com/cgi-bin/prnh/20091029/CG01324 ...
... per week can improve osteoarthritis symptoms in older patients, study ... improve that osteoarthritis in your knee? New research suggests that ... knee function better. , "Tai Chi is a mind-body ... adults with knee osteoarthritis," Dr. Chenchen Wang, co-author of a ...
... American Diabetes Wholesale ... , ... FL (PRWEB) October 29, 2009 -- American Diabetes Wholesale received the South Florida Business Journal ... The South Florida Business Journal Awards recognize health care providers and professionals in the areas ...
... determined that patients over 65 years of age with ... exercise improve physical function and experience less pain. ... martial arts that features slow, rhythmic movements to induce ... Full findings of the study are published in the ...
Cached Medicine News:Health News:Practice-changing cancer studies presented at major cancer meeting 2Health News:Cascades Launches Information Campaign on Hand Drying 2Health News:Cascades Launches Information Campaign on Hand Drying 3Health News:Children's Hospitals and Clinics of Minnesota Announces Scott Leitz as New Director of Child Health Policy and Advocacy 2Health News:Tai Chi May Help Ward Off Knee Pain in Seniors 2Health News:American Diabetes Wholesale Wins 2009 Excellence In Health Care Award from South Florida Business Journal 2Health News:Research shows Tai Chi exercise reduces knee osteoarthritis pain in the elderly 2
Sierra Wave Quickreport eliminates most dictation. Study driven functions make testing faster and easier. Complete 2/4 channel EMG/NCV/EP....
Quickly displays crisp, clear charts....
...
... 3 year warranty Set one of two ... B.I.O. exam!, One touch auto return button, ... 4 colors , Solid-State push button control ... and transformer. , Electro-Magnetic counter-balanced slit lamp ...
Medicine Products: