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Isis Pharmaceuticals Reports Positive Phase 1 Data On Three Drugs In Development To Treat Metabolic Disorders
Date:12/7/2012

tion and enhances insulin secretion, that confirmed the activity we observed in our preclinical studies," continued Dr. Bhanot.  "Given the unique mechanism of action and potentially favorable safety profile observed in the Phase 1 study, we believe that ISIS-GCGRRx could be valuable for diabetic patients with severe hyperglycemia who are not controlled with current treatments by not only controlling glucose, but also preserving pancreatic function, which would enhance endogenous insulin activity."

ISIS-GCCRRx
ISIS-GCCRRx targets the glucocorticoid receptor (GCCR) and is designed to reduce the effects of glucocorticoids, hormones that promote liver glucose production and fat storage in the liver and fat tissues.  Because excessive GCCR activity in the liver and fat is associated with obesity, insulin resistance and glucose intolerance, ISIS-GCCRRx has the potential to improve glycemic and lipid control in patients with type 2 diabetes.  "Reduction of GCCR in tissues other than the liver and fat, such as the brain, can result in many unwanted and potentially toxic side effects, as has been reported with small molecule inhibitors of GCCR.  Because ISIS-GCCRRx reduces GCCR activity only in liver and fat tissues, we avoid these unwanted side effects.  In preclinical studies, we demonstrated that antisense reduction of GCCR was limited to the liver and fat tissues and produced robust lowering of glucose and lipid levels.  Results from our ISIS-GCCRRx Phase 1 study were consistent with the liver- and fat-specific activity we observed in our preclinical studies, and also provided early encouraging data on the drug's therapeutic activity," concluded Dr. Bhanot.  "Given the mechanism of action, we believe that ISIS-GCCRRx could be particularly useful for diabetic patients with moderate to severe hyperglycemia who are also obese or have high levels of ch
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SOURCE Isis Pharmaceuticals, Inc.
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