Navigation Links
Isis Pharmaceuticals Reports Positive Phase 1 Data On Three Drugs In Development To Treat Metabolic Disorders
Date:12/7/2012

CARLSBAD, Calif., Dec. 7, 2012 /PRNewswire/ -- Isis Pharmaceuticals, Inc. (NASDAQ: ISIS) announced today positive results from Phase 1 studies of three drugs, ISIS-PTP1BRx, ISIS-GCGRRx and ISIS-GCCRRx, in development to treat metabolic disorders, including type 2 diabetes.  In all three Phase 1 studies, the drugs were safe and well tolerated with early encouraging data that supports the unique mechanism of each drug. All three drugs are part of Isis' metabolic franchise and are designed to act through distinct mechanisms to improve insulin sensitivity and/or reduce glucose production. 

"Our goal is to develop safe, effective drugs with unique mechanisms of action that can provide significant therapeutic benefit for patients with metabolic disorders, including type 2 diabetes. This year we have moved closer to this goal with the completion of our initial clinical studies on three promising drugs from our metabolic franchise.  These drugs are uniquely positioned to fill the critical voids in diabetes therapy," said Stanley T. Crooke, M.D., Ph.D., chief executive officer at Isis.  "While these drugs may be beneficial as single agents, our goal is to develop them as adjuncts to existing diabetes therapies.  We believe that each drug has the potential to address a distinct and significant commercial market in patients with type 2 diabetes."

ISIS-PTP1BRx
ISIS-PTP1BRx targets protein tyrosine phosphatase-1B (PTP-1B) and is designed to increase the body's sensitivity to insulin, resulting in better glucose control for patients with type 2 diabetes.  Because of its unique mechanism, ISIS-PTP1BRx has the potential to help patients achieve glucose control without weight gain or hypoglycemia.  In the Phase 1 study of ISIS-PTP1BRx in obese healthy volunteers, I
'/>"/>

SOURCE Isis Pharmaceuticals, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. AcelRx Pharmaceuticals Announces Pricing of Public Offering of Common Stock
2. Arena Pharmaceuticals to Present at the Oppenheimer 23rd Annual Healthcare Conference
3. Valeant Pharmaceuticals And Galderma Agree On Revised Agreement Terms
4. Optimer Pharmaceuticals to Present at 23rd Annual Oppenheimer Healthcare Conference
5. AcelRx Pharmaceuticals Announces Proposed Public Offering Of Common Stock
6. Additional Clinical Data from Two Trials on Actinium Pharmaceuticals Iomab-B to be Presented at American Society of Hematology (ASH) Annual Meeting
7. Salix Pharmaceuticals Donates $500,000 To ASGEs IT&T Capital Campaign To Build A New State-of-the-Art GI Training Center
8. Questcor Pharmaceuticals Accelerates Cash Dividend; Payment Date Set for December 21, 2012
9. Double-digit Growth Rate of the Pharmaceuticals Industry in Asia Pacific Boosts the API Market, Finds Frost & Sullivan
10. Cadence Pharmaceuticals to Host Analyst and Investor Day
11. Nobel Prize Winner Bruce Beutler joins Sound Pharmaceuticals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2015)... Mass. , Aug. 27, 2015  A ... the KSSTA Knee Journal, compared the Arthrosurface HemiCAP® ... Arthroplasty design, versus an "onlay" design implant for ... similar improvements in function and pain scores, none ... progression of osteoarthritis (OA). However, 53% of the ...
(Date:8/27/2015)... , Aug. 27, 2015 Biosimilars ... (BPC) applauds the U.S. Food and Drug Administration ... distinguishable name in its draft guidance issued today. ... biological products proposes distinguishable names, calling for biological ... an FDA-designated suffix. This proposal reflects the agency,s ...
(Date:8/27/2015)... 2015 According to a new market research ... Universal, Standing, Bariatric ), Material (Nylon, Padded, Canvas), Usage Type (Disposable, ... by MarketsandMarkets, the Medical Lifting Sling Market is poised to reach ... at a CAGR of 11.4 % from 2015 to 2020. ... rket data T ables and 65 ...
Breaking Medicine Technology:Study Demonstrates Dramatic Reduction in Progression of Osteoarthritis with the Arthrosurface "Inlay" Patellofemoral Implant Design Compared to Traditional "Onlay" Implant 2Study Demonstrates Dramatic Reduction in Progression of Osteoarthritis with the Arthrosurface "Inlay" Patellofemoral Implant Design Compared to Traditional "Onlay" Implant 3Biologics Prescribers Collaborative (BPC) Statement on FDA Draft Guidance entitled "Nonproprietary Naming of Biological Products" 2Medical Lifting Sling Market Worth USD 706.0 Million by 2020 2Medical Lifting Sling Market Worth USD 706.0 Million by 2020 3Medical Lifting Sling Market Worth USD 706.0 Million by 2020 4
(Date:8/28/2015)... ... , ... Dr. Gregory K. Toumayan, D.C., Q.M.E., is now treating patients with ... pain, hip pain, neck pain, stiffness, muscle spasms, and numbness. , Dr. Toumayan ... then went on to earn his title of Doctor of Chiropractic from the Palmer ...
(Date:8/28/2015)... ... August 28, 2015 , ... Northridge dentists ... teeth whitening. For just $199, patients can currently receive a one hour treatment of ... whitening procedures, but it includes a number of unique features that can turn teeth ...
(Date:8/28/2015)... ... 28, 2015 , ... Healthpointe clinics throughout Southern California ... diving. The act of recreational diving exposes the body to extreme changes ... vital that all recreational and professional divers undergo regular comprehensive scuba physicals. Healthpointe’s ...
(Date:8/28/2015)... , ... August 28, 2015 ... ... Inc.’s (AIS) Medicare-Medicaid Dual Eligibles Database have added comprehensive information on two ... demonstration approved for a December 2015 launch; and Idaho’s partnership to revamp ...
(Date:8/28/2015)... ... 2015 , ... External Counterpulsation, also known as ECP or EECP, is a ... (EECP or ECP) machines with a full clinic licence to help people prevent and ... helping people prevent and reverse heart disease through its evidence-based integrative approach ...
Breaking Medicine News(10 mins):Health News:Healthpointe Welcomes Dr. Gregory K. Toumayan, Chiropractor, to Colton, Temecula, and Perris 2Health News:Healthpointe Welcomes Dr. Gregory K. Toumayan, Chiropractor, to Colton, Temecula, and Perris 3Health News:Northridge Dentists Dr. Elyson and Dr. Assili Now Offer a Special Promotion on Zoom Teeth Whitening 2Health News:Healthpointe Now Offering Scuba Physicals 2Health News:AIS Duals Database: August Update Finds Two New Duals Programs in Rhode Island and Idaho 2Health News:Buy New External Counterpulsation (EECP or ECP) With Heart Fit Clinic 2
... , , , ... through Delivery-system Reforms , , WASHINGTON, ... brought together several health care experts to discuss ways to "get ... promotes the health of all Americans through better prevention and management ...
... TAMPA, Fla., Sept. 16 If the troubled economy has ... for knowledge and hard work. Speculators can finagle a decent living ... often unemployment, bankruptcy and foreclosure when times get tough. Those who ... it will provide the kind of success that lasts a lifetime ...
... , , LOS ANGELES, Sept. 16 ... awarded LA,s Best Award (tm) 2009 for his leading edge, high ... work in cosmetic dentistry and bite reconstruction and has recently trademarked ... dental technologies to achieve a level of care that is beyond ...
... , , , ... Occupational HealthLink, Inc., today announced it has changed its business ... , "We are very excited about the ... Axion Health allows us to better represent our business as ...
... , MURRIETA, Calif., Sept. 16 ... provides drug and alcohol rehabilitation and a variety of other behavioral ... it has updated its web sites at www.forterushealthcare.com ... facility. , , "It is very important that ...
... ... Wake Forest, NC-based company that is recognized as the leading provider of care management ... ... 2009 -- Digital Healthcare, the Cambridge England and Wake Forest, NC based company that ...
Cached Medicine News:Health News:National Coalition Brings Together Experts to Evaluate Current Health Reform Proposals on Wellness, Disease Prevention Provisions 2Health News:Learn Your Way to Success 2Health News:Learn Your Way to Success 3Health News:Los Angeles Dentist Dr. Sam Muslin Receives LA's Best Award 2009 2Health News:Los Angeles Dentist Dr. Sam Muslin Receives LA's Best Award 2009 3Health News:Los Angeles Dentist Dr. Sam Muslin Receives LA's Best Award 2009 4Health News:Los Angeles Dentist Dr. Sam Muslin Receives LA's Best Award 2009 5Health News:Los Angeles Dentist Dr. Sam Muslin Receives LA's Best Award 2009 6Health News:Los Angeles Dentist Dr. Sam Muslin Receives LA's Best Award 2009 7Health News:Axion Health Inc. Issues Notification of Business Name Change 2Health News:Axion Health Inc. Issues Notification of Business Name Change 3Health News:Forterus Inc. Launches Updated, Improved Web Site 2Health News:Retasure and Digital Healthcare Celebrate 10 Year Anniversary 2