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Isis Pharmaceuticals Reports Positive Phase 1 Data On Three Drugs In Development To Treat Metabolic Disorders
Date:12/7/2012

CARLSBAD, Calif., Dec. 7, 2012 /PRNewswire/ -- Isis Pharmaceuticals, Inc. (NASDAQ: ISIS) announced today positive results from Phase 1 studies of three drugs, ISIS-PTP1BRx, ISIS-GCGRRx and ISIS-GCCRRx, in development to treat metabolic disorders, including type 2 diabetes.  In all three Phase 1 studies, the drugs were safe and well tolerated with early encouraging data that supports the unique mechanism of each drug. All three drugs are part of Isis' metabolic franchise and are designed to act through distinct mechanisms to improve insulin sensitivity and/or reduce glucose production. 

"Our goal is to develop safe, effective drugs with unique mechanisms of action that can provide significant therapeutic benefit for patients with metabolic disorders, including type 2 diabetes. This year we have moved closer to this goal with the completion of our initial clinical studies on three promising drugs from our metabolic franchise.  These drugs are uniquely positioned to fill the critical voids in diabetes therapy," said Stanley T. Crooke, M.D., Ph.D., chief executive officer at Isis.  "While these drugs may be beneficial as single agents, our goal is to develop them as adjuncts to existing diabetes therapies.  We believe that each drug has the potential to address a distinct and significant commercial market in patients with type 2 diabetes."

ISIS-PTP1BRx
ISIS-PTP1BRx targets protein tyrosine phosphatase-1B (PTP-1B) and is designed to increase the body's sensitivity to insulin, resulting in better glucose control for patients with type 2 diabetes.  Because of its unique mechanism, ISIS-PTP1BRx has the potential to help patients achieve glucose control without weight gain or hypoglycemia.  In the Phase 1 study of ISIS-PTP1BRx in obese healthy volunteers, I
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SOURCE Isis Pharmaceuticals, Inc.
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