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Isis Pharmaceuticals Reports Positive Phase 1 Data Demonstrating ISIS-APO(a) Rx Produces Significant Reductions in Lp(a) Levels
Date:11/16/2013

SIS-APO(a)Rx in patients with existing cardiovascular disease and high Lp(a) levels.  Individuals with high Lp(a) levels are at increased risk for cardiovascular events and need to substantially reduce their Lp(a).  We look forward to getting this program underway."

"Patients with high Lp(a) levels are at significant cardiovascular risk.  Unfortunately for these patients, current lipid-lowering drugs, such as statins, are unable to lower Lp(a) to recommended safe levels.  As such, new treatment approaches are needed.  As a patient with high Lp(a) and the president and founder of the Lipoprotein(a) Foundation, I am gratified with the increased emphasis in the cardiovascular community on Lp(a) and for the work that is being done on developing focused, targeted approaches to lowering Lp(a),"  said Sandra Revill Tremulis, president and founder of the Lipoprotein(a) Foundation.  "I am encouraged by the Phase 1 data presented today on ISIS-APO(a)Rx and hopeful that this approach to lowering Lp(a) could, for the first time, offer patients an effective, direct option to reducing their Lp(a)."

ISIS-APO(a)Rx is a wholly owned antisense drug targeting apolipoprotein(a) for the treatment of atherosclerosis.  Apolipoprotein(a) contributes to the formation of plaque in arteries through its attachment to an LDL-C particle in a complex called Lp(a).  High levels of Lp(a) are associated with an increased risk of atherosclerosis, coronary heart disease, heart attack and stroke.  While statins and other lipid-lowering drugs have a modest effect on lowering Lp(a), patients with elevated Lp(a) are unable to reach recommended safe Lp(a) levels.  ISIS-APO(a)Rx is designed to reduce Lp(a) by inhibiting the production of apolipoprotein(a).  Isis plans to develop ISIS-APO(a)Rx to treat patients with high Lp(a) levels who are at high ris
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SOURCE Isis Pharmaceuticals, Inc.
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