Navigation Links
Isis Pharmaceuticals Reports Fifth Positive Phase 2 Data Set for ISIS-APOCIII Rx Showing Significant Reductions in Triglyceride and ApoC-III Levels
Date:11/18/2013

e no flu-like symptoms, no treatment-related elevations of liver enzymes greater than three times upper limit of normal, no abnormalities in renal function and no clinically meaningful changes in other laboratory values.

"We have now demonstrated that ISIS-APOCIIIRx has the ability to lower triglycerides equally well in patients with high to severely high triglycerides as well as in patients with high triglycerides and type 2 diabetes.  We have demonstrated that ISIS-APOCIIIRx can work equally well as a single agent and in combination with fibrates to produce significant reductions in apoC-III and triglycerides, and increases in HDL-C.  In addition, the observed positive effect of ISIS-APOCIIIRx treatment on lipid parameters, improvements in glucose control and trends toward improvements in insulin sensitivity, suggest that ISIS-APOCIIIRx could have a very attractive therapeutic profile for patients with severely high triglycerides, who often also have diabetes or metabolic syndrome," said Richard Geary, Ph.D., senior vice president of development at Isis. 

ISIS-APOCIIIRx is an antisense drug intended to treat patients with severely high triglycerides either as a single agent or in combination with other triglyceride-lowering agents.  ISIS-APOCIIIRx targets apoC-III, a protein produced in the liver that plays a central role in the regulation of serum triglycerides.  Humans who do not produce apoC-III have lower levels of triglycerides and lower instances of cardiovascular disease.  In clinical studies, patients with lower levels of apoC-III and triglycerides exhibit lower cardiovascular event rates.  Humans with elevated levels of apoC-III have increased dyslipidemia associated with multiple metabolic abnormalities, such as insulin resistance and/or metabolic syndrome.  In addition, the prevalence of type 2 diabetes i
'/>"/>

SOURCE Isis Pharmaceuticals, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Savient Pharmaceuticals to Hold First Quarter 2012 Financial Results Conference Call on Wednesday, May 9, 2012
2. Auxilium Pharmaceuticals to Present at the Deutsche Bank 37th Annual Healthcare Conference
3. Nouveau Life Pharmaceuticals (HRID) Contracts with U.S. Manufacturer to Produce New Female Supplement
4. BioElectronics Survey Indicates a Five-Fold Superior Pain Relief Compared to OTC Pharmaceuticals
5. Icahn Issues Statement Regarding Amylin Pharmaceuticals
6. Almost 50 Percent of the Glaucoma Patient Population Remains Untreated, Signifying a Vast Market for Glaucoma Pharmaceuticals, Finds Frost & Sullivan
7. Omthera Pharmaceuticals Announces Positive Top-Line Results from Phase 3 EVOLVE Study
8. Onyx Pharmaceuticals Announces FDA Advisory Committee to Review Carfilzomib for the Treatment of Patients with Relapsed and Refractory Multiple Myeloma
9. Jazz Pharmaceuticals Announces First Quarter 2012 Financial Results Conference Call On May 8, 2012
10. Inovio Pharmaceuticals Granted U.S. Patent Protection for Synthetic Vaccine for Cervical Dysplasia and Cancer
11. Avanir Pharmaceuticals To Present at Three Conferences In May
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... , July 31, 2014 Vermillion, Inc. (NASDAQ: VRML), ... health, will hold a conference call on Thursday, August 14, ... the second quarter ended June 30, 2014. Financial results will ... Vermillion,s Chairman, President and CEO James LaFrance ... answer period. Date: Thursday, August 14, 2014 Time: ...
(Date:7/31/2014)... , July 31, 2014  Today, Levi ... new extension to its PageCenterX ® content ... is designed to provide downtime reporting capabilities to ... LRS is releasing the product for general availability, ... EMR applications experience outages for a variety of ...
(Date:7/31/2014)... WASHINGTON , July 31, 2014  CVS/pharmacy ... first pharmacy in the nation to earn the ... health care accreditation organization that establishes quality standards ... Longs Drug Store locations nationwide have earned this ... accreditation programs. Its Community Pharmacy Accreditation Program was ...
Breaking Medicine Technology:Vermillion Sets Second Quarter 2014 Conference Call for Thursday, August 14, 2014 2LRS Announces Downtime Reporting Solution for Healthcare 2CVS/pharmacy Earns First-Ever Community Pharmacy Accreditation from URAC 2CVS/pharmacy Earns First-Ever Community Pharmacy Accreditation from URAC 3
... Oct. 23 Optimer Pharmaceuticals, Inc. (Nasdaq: ... from its two fidaxomicin Phase 3 trials in patients ... 48th Annual Meeting of the Infectious Disease Society of ... oral presentation, investigator Derrick Crook, M.D., of the University ...
... 22 Amedisys, a leading home health care and hospice company ... on the future of home care in this week,s issue of ... of the Amedisys Strategic Advisory Board. Titled, "Why ... on the future of home care as an increasingly crucial component ...
Cached Medicine Technology:Optimer Pharmaceuticals Announces Combined Data From Fidaxomicin Phase 3 Trials for the Treatment of Clostridium difficile Infection (CDI) Presented at IDSA 2Optimer Pharmaceuticals Announces Combined Data From Fidaxomicin Phase 3 Trials for the Treatment of Clostridium difficile Infection (CDI) Presented at IDSA 3Optimer Pharmaceuticals Announces Combined Data From Fidaxomicin Phase 3 Trials for the Treatment of Clostridium difficile Infection (CDI) Presented at IDSA 4Optimer Pharmaceuticals Announces Combined Data From Fidaxomicin Phase 3 Trials for the Treatment of Clostridium difficile Infection (CDI) Presented at IDSA 5Media Statement From Amedisys on Dr. Steven H. Landers' NEJM Commentary on the Future of Home Care 2
(Date:7/31/2014)... largest genetic analysis of what triggers and propels progression ... researchers at NYU Langone Medical Center report that they ... the disease. , T-cell acute lymphoblastic leukemia is ... cancers. An estimated quarter of the 500 adolescents and ... the U.S. fail to achieve remission with standard chemotherapy ...
(Date:7/31/2014)... 31, 2014 According to a new ... Fixation Devices Market - Global Forecast, Market Share, Size, ... orthopedic trauma fixation devices market is estimated at USD ... at a CAGR of 7.2% from 2014 to 2019, ... in 2020. Globally, the orthopedic trauma fixation devices market ...
(Date:7/31/2014)... Irvine, Calif., July 31, 2014 Much of the ... our own body clock and UC Irvine researchers ... occurs. , The study, published online today in ... sway over metabolism and points the way to more ... disorders as obesity and diabetes. , Paolo Sassone-Corsi, UCI,s ...
(Date:7/31/2014)... News) -- A new report finds that by 2010, one ... involved diabetes, with the greatest rise among those aged 25 ... Control and Prevention found the number of office visits for ... percent between 2005 and 2010. Almost 29 million Americans ... disease costs almost $245 billion each year. Diabetes falls into ...
(Date:7/31/2014)... Longmont, Colo. (PRWEB) July 31, 2014 ... snacks, has launched three new products including: a Cacao Nib ... Like all Two Moms in the Raw products, each is ... , “My family is picky, so I’m constantly working on ... our consumers more healthy and tasty choices,” said Shari Leidich, ...
Breaking Medicine News(10 mins):Health News:Drug target identified for common childhood blood cancer 2Health News:Drug target identified for common childhood blood cancer 3Health News:Orthopedic Trauma Fixation Devices Market: Global Forecast, Share, Size, Growth and Industry Analysis 2014 - 2020 2Health News:Orthopedic Trauma Fixation Devices Market: Global Forecast, Share, Size, Growth and Industry Analysis 2014 - 2020 3Health News:Strict genomic partitioning by biological clock separates key metabolic functions 2Health News:Big Jump in Doctor's Office Visits for Young Adults With Diabetes 2Health News:Two Moms in the Raw Launches Three New, Raw, Sprouted 100% Organic Snacks 2Health News:Two Moms in the Raw Launches Three New, Raw, Sprouted 100% Organic Snacks 3
... male and female hormones play role in making men masculine, ... behavior patterns are often chalked up to testosterone in men ... the hormone issue isn,t so clear cut. , The male ... when it comes to masculinizing the brain during development and ...
... of a landmark study refutes link between intensive therapy, higher ... Action to Control Cardiovascular Risk in Diabetes (ACCORD) study was ... deaths in the group of type 2 diabetics who were ... to near-normal levels. , Now, a new analysis of ...
... Among the general U.S. population, people who are uninsured ... services as those with insurance, according to systematic review ... Disparities Group. They also found that once admitted to ... likely to have invasive procedures or pulmonary artery catheterizations ...
... 2010 Patients recovering from stroke sometimes behave as if ... obstacles on their left, eating food only from the right ... side. This puzzling phenomenon is termed "spatial neglect" and it ... the right side of the brain. The condition can indicate ...
... Fibromyalgia is a condition that causes chronic, widespread pain ... Missouri researchers are examining how the diagnosis of Fibromyalgia ... have considerably higher levels of depressive symptoms and pain ... spouses. For both spouses, the symptoms can trigger increased ...
... Teaching babies to swim turns out to be more than ... better at grasping at things than non-swimmers. This difference persists ... have been taught to swim still outperform their peers. ... psychology at the Norwegian University of Science and Technology. ...
Cached Medicine News:Health News:Typical Male Behavior Comes From Estrogen, Too 2Health News:Tight Blood Sugar Control May Not Harm Diabetics 2Health News:Tight Blood Sugar Control May Not Harm Diabetics 3Health News:ATS systematic review: Critical care outcomes tied to insurance status 2Health News:ATS systematic review: Critical care outcomes tied to insurance status 3Health News:Lottery game helps to assess brain damage following stroke 2Health News:Fibromyalgia affects mental health of those diagnosed and their spouses, study finds 2Health News:Baby swimmers have better balance 2
Abdominal Binder w / Velcro...
Ideal for abdominal, flank, hip and thigh procedures....
Male high waisted compression girdle with CDIs Wonderfabric™...
This high waist tummy tuck girdle provides the same CDI Wonderfabric™ compression as the 8000 series....
Medicine Products: