Navigation Links
Isis Pharmaceuticals Reports Encouraging Data on ISIS-STAT3rx in Patients With Cancer

CARLSBAD, Calif., June 3, 2013 /PRNewswire/ -- Isis Pharmaceuticals, Inc. (NASDAQ: ISIS) announced that data from the Phase 1 study of ISIS-STAT3Rx in patients with cancer were presented today at the American Society of Clinical Oncology in Chicago.  Results of the initial dose escalation study in patients with metastatic cancer showed that ISIS-STAT3Rx treatment resulted in partial responses that were durable and prolonged in two out of three patients with diffuse large B-cell lymphoma (DLBCL) who were refractory to prior chemotherapy treatments.  Isis and AstraZeneca are currently evaluating ISIS-STAT3Rx, in two clinical studies in patients with advanced lymphoma and metastatic liver cancer.

"STAT3 activation has been shown to be associated with the growth, invasiveness and metastases of many types of cancer making it an attractive anti-cancer target.  However, STAT3 has proven to be a difficult target to inhibit.  ISIS-STAT3Rx is one of the new molecules in development that inhibit STAT3," said David S. Hong , M.D., associate professor, department of investigational cancer therapeutics at the University of Texas MD Anderson Cancer Center.  "Patients with advanced cancer often have failed multiple therapies and have few other chemotherapeutic options.  For these patients there is a desperate need for new therapies that can halt their disease progression.  The clinical responses observed to date suggest that inhibition of STAT3 could provide benefit to some of these cancer patients.   The early clinical data on ISIS-STAT3Rx is impressive because it suggests that this drug can produce durable responses in patients with advanced cancer who have failed to respond to other therapies."

ISIS-STAT3Rx, also referred to as AZD9150, is the first drug in Isis' pipeline that incorporates Isis' Generation 2.5 chemistry, which Isis developed to increase potency of antisense drugs, thereby creating opportunities for drugs like ISIS-STAT3Rx to be effective in more difficult-to-treat cancers, like DLBCL.  The open-label, dose-escalation Phase 1 study evaluated ISIS-STAT3Rx in 15 patients with advanced solid tumors and lymphoma who had relapsed or were refractory to multiple chemotherapy regimens. Signals of tumor responses were observed in four patients, including objective partial responses in two of three patients with DLBCL.  One patient with a partial response with DLBCL, who had previously failed ten different chemotherapy regimens, experienced a 50 percent reduction in tumor burden and has maintained a partial response for longer than one year and continues to receive weekly ISIS-STAT3Rx therapy.   Another patient with DLBCL experienced a partial response with a 65 percent reduction in tumor burden and, as a result, was well enough to receive an autologous stem cell transplant.   This patient successfully completed a bone marrow transplant and remains disease free.  Isis and AstraZeneca are currently evaluating ISIS-STAT3Rx in two other clinical studies, including a study in patients with advanced lymphomas, like DLBCL, and a study in patients with advanced metastatic hepatocellular carcinoma. 

"AstraZeneca's considerable expertise in developing anti-cancer drugs has enabled us to rapidly advance the clinical development of ISIS-STAT3Rx.  We believe that ISIS-STAT3Rx may be applicable to many different types of cancer.  As such, together with AstraZeneca, we plan to evaluate ISIS-STAT3Rx in a broad Phase 2 program," said Brett Monia , Ph.D., senior vice president, antisense drug discovery at Isis.  "We are very pleased and encouraged with the safety and efficacy observed in our initial clinical study of ISIS-STAT3Rx and look forward to the results from the two ongoing clinical studies in patients, which we plan to report next year."

ISIS-STAT3Rx is designed to inhibit the production of signal transducer and activator of transcription 3 (STAT3), a protein critical for tumor cell growth and survival.  In addition, STAT3 is an important mediator of signaling in the JAK2/STAT3 pathway, which has been previously shown to be an important target for drug development.  Because STAT3 is activated in numerous types of cancer, ISIS-STAT3Rx has the potential to be broadly useful for both solid and hematologic tumors.  ISIS-STAT3Rx has been shown to reduce STAT3 levels in preclinical tumor models and produce anti-tumor activity.  Inhibition of STAT3 has also been shown to block the induction of tumor-associated cytokines involved in the progression of cancer, such as IL-6, IL-1, TGF, and IL-10, which could serve as important biomarkers in clinical studies.  

Conference Call

At 2:00 p.m. Eastern Time today, June 3, 2013, Isis will conduct a live webcast conference call to discuss recent highlights from its cancer franchise, including the addition of ISIS-ARRx to its cancer franchise and data from the Phase 1 study of ISIS-STAT3Rx that was presented today at the American Society of Clinical Oncology.  Interested parties may listen to the call by dialing 866-652-5200, or access the webcast at  A webcast replay will be available for a limited time at the same address.


Isis is exploiting its leadership position in antisense technology to discover and develop novel drugs for its product pipeline and for its partners.  Isis' broad pipeline consists of 28 drugs to treat a wide variety of diseases with an emphasis on cardiovascular, metabolic, severe and rare diseases, and cancer.  Isis' partner, Genzyme, is commercializing Isis' lead product, KYNAMRO™, in the United States for the treatment of patients with HoFH.  Genzyme is also pursuing marketing approval of KYNAMRO in other markets.  Isis' patents provide strong and extensive protection for its drugs and technology.  Additional information about Isis is available at


This press release includes forward-looking statements regarding Isis' strategic alliance with AstraZeneca, the development, activity, therapeutic potential and safety of ISIS-STAT3Rx, and the therapeutic benefit of antisense drugs that incorporate Isis' Generation 2.5 chemistry.  Any statement describing Isis' goals, expectations, financial or other projections, intentions or beliefs, including the commercial potential of KYNAMRO, is a forward-looking statement and should be considered an at-risk statement.  Such statements are subject to certain risks and uncertainties, particularly those inherent in the process of discovering, developing and commercializing drugs that are safe and effective for use as human therapeutics, and in the endeavor of building a business around such drugs.  Isis' forward-looking statements also involve assumptions that, if they never materialize or prove correct, could cause its results to differ materially from those expressed or implied by such forward-looking statements.  Although Isis' forward-looking statements reflect the good faith judgment of its management, these statements are based only on facts and factors currently known by Isis.  As a result, you are cautioned not to rely on these forward-looking statements.  These and other risks concerning Isis' programs are described in additional detail in Isis' annual report on Form 10-K for the year ended December 31, 2012, and its most recent quarterly report on Form 10-Q, which are on file with the SEC. Copies of these and other documents are available from the Company.

In this press release, unless the context requires otherwise, "Isis," "Company," "we," "our," and "us" refers to Isis Pharmaceuticals and its subsidiaries.

Isis Pharmaceuticals® is a registered trademark of Isis Pharmaceuticals, Inc.  KYNAMRO™ is a trademark of Genzyme Corporation.

Isis Pharmaceuticals' Contacts:

D. Wade Walke, Ph.D.

Executive Director, Corporate Communications and Investor Relations


Amy Blackley, Ph.D.

Associate Director, Corporate Communications



SOURCE Isis Pharmaceuticals, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. Savient Pharmaceuticals to Hold First Quarter 2012 Financial Results Conference Call on Wednesday, May 9, 2012
2. Auxilium Pharmaceuticals to Present at the Deutsche Bank 37th Annual Healthcare Conference
3. Nouveau Life Pharmaceuticals (HRID) Contracts with U.S. Manufacturer to Produce New Female Supplement
4. BioElectronics Survey Indicates a Five-Fold Superior Pain Relief Compared to OTC Pharmaceuticals
5. Icahn Issues Statement Regarding Amylin Pharmaceuticals
6. Almost 50 Percent of the Glaucoma Patient Population Remains Untreated, Signifying a Vast Market for Glaucoma Pharmaceuticals, Finds Frost & Sullivan
7. Omthera Pharmaceuticals Announces Positive Top-Line Results from Phase 3 EVOLVE Study
8. Onyx Pharmaceuticals Announces FDA Advisory Committee to Review Carfilzomib for the Treatment of Patients with Relapsed and Refractory Multiple Myeloma
9. Jazz Pharmaceuticals Announces First Quarter 2012 Financial Results Conference Call On May 8, 2012
10. Inovio Pharmaceuticals Granted U.S. Patent Protection for Synthetic Vaccine for Cervical Dysplasia and Cancer
11. Avanir Pharmaceuticals To Present at Three Conferences In May
Post Your Comments:
(Date:6/20/2017)... -- Hill-Rom Holdings, Inc. (NYSE: HRC), will host its fiscal third ... 28, 2017, beginning at 7:30 a.m. (CDT) / 8:30 a.m. ... participate in the conference call, dial (877) 304-8969 (domestic) or ... 10 minutes prior to the start to allow time to ... Webcast: A simultaneous webcast of the call ...
(Date:6/16/2017)... 2017 Datascope Corp. is voluntarily performing a worldwide field correction ... electrical test failure code.     ... PART NUMBER ... 0998-UC-0446HXX; 0998-UC-0479HXX 0998-00-3013-XX;  ... This field correction also applies ...
(Date:6/14/2017)...  ivWatch LLC, a medical device company focused on ... is pleased to announce it was the Bronze Winner ... and Equipment at the 2017 Medical Design Excellence Awards ... The award was presented by Medical Device and Diagnostics ... New York during MD&M East, ...
Breaking Medicine Technology:
(Date:6/28/2017)... ... June 28, 2017 , ... ... consultations to communities in northern Virginia and DC, is announcing a cooperative charity ... patients with Alzheimer’s and other disorders that lead to memory impairment. , The ...
(Date:6/27/2017)... ... June 27, 2017 , ... Harbour , a DAO (decentralized autonomous organization) ... blockchain, has released their technical specifications . , 2017 has seen an explosion ... approach for determining which offerings will garner the greatest ROI. Dean Eigenmann, Co-founder and ...
(Date:6/27/2017)... ... ... A January 18th article on medGadget reports that the worldwide ... year 2024 according to a new report. The article also notes that the newer ... Angeles area clinic Beverly Hills Periodontics & Dental Implant Center says that it is ...
(Date:6/27/2017)... CT (PRWEB) , ... June 27, 2017 , ... ... Alice P. Fabrykiewicz Scholarship Foundation Fundraiser hygiene symposium in Mystic, CT. Covering the ... and Urbanski offered their experience in these popular periodontal procedures. Drs. Toback and ...
(Date:6/27/2017)... ... 27, 2017 , ... East Los Angeles dentist, Ramin Assili DDS , ... What happens to a woman during pregnancy can have profound effects on a developing ... toll on a baby’s long-term health. This study, which was performed at the University ...
Breaking Medicine News(10 mins):