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Isis Pharmaceuticals Reports Encouraging Data on ISIS-STAT3rx in Patients With Cancer
Date:6/3/2013

CARLSBAD, Calif., June 3, 2013 /PRNewswire/ -- Isis Pharmaceuticals, Inc. (NASDAQ: ISIS) announced that data from the Phase 1 study of ISIS-STAT3Rx in patients with cancer were presented today at the American Society of Clinical Oncology in Chicago.  Results of the initial dose escalation study in patients with metastatic cancer showed that ISIS-STAT3Rx treatment resulted in partial responses that were durable and prolonged in two out of three patients with diffuse large B-cell lymphoma (DLBCL) who were refractory to prior chemotherapy treatments.  Isis and AstraZeneca are currently evaluating ISIS-STAT3Rx, in two clinical studies in patients with advanced lymphoma and metastatic liver cancer.

"STAT3 activation has been shown to be associated with the growth, invasiveness and metastases of many types of cancer making it an attractive anti-cancer target.  However, STAT3 has proven to be a difficult target to inhibit.  ISIS-STAT3Rx is one of the new molecules in development that inhibit STAT3," said David S. Hong , M.D., associate professor, department of investigational cancer therapeutics at the University of Texas MD Anderson Cancer Center.  "Patients with advanced cancer often have failed multiple therapies and have few other chemotherapeutic options.  For these patients there is a desperate need for new therapies that can halt their disease progression.  The clinical responses observed to date suggest that inhibition of STAT3 could provide benefit to some of these cancer patients.   The early clinical data on ISIS-STAT3Rx is impressive because it suggests that this drug can produce durable responses in patients with advanced cancer who have failed to respond to other therapies."

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SOURCE Isis Pharmaceuticals, Inc.
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