Navigation Links
Isis Pharmaceuticals Reports Data From a Phase 2 Study of Isis-CRP Rx in Patients with Rheumatoid Arthritis
Date:8/5/2013

CARLSBAD, Calif., Aug. 5, 2013 /PRNewswire/ -- Isis Pharmaceuticals, Inc. (NASDAQ: ISIS) announced that patients treated with ISIS-CRPRx achieved rapid, dose-dependent mean reductions of up to 67 percent in C-reactive protein (CRP) in a Phase 2 study in patients with rheumatoid arthritis (RA).  Patients treated with ISIS-CRPRx showed improvements in signs and symptoms of RA; however, these improvements were not statistically significant when compared to those observed in patients in the placebo group, which demonstrated a higher than expected response in both symptom score and CRP reduction.  A Phase 2 study of ISIS-CRPRx in patients with atrial fibrillation is currently ongoing with data anticipated in the first half of 2014.

"CRP is strongly associated with the presence and severity of many diseases, including numerous inflammatory and cardiovascular diseases.  In this study, by treating patients with chronically elevated CRP with ISIS-CRPRx, we hoped to accomplish three things:  to confirm in patients the substantial CRP-lowering activity we observed in our earlier clinical studies, to gain additional experience with the drug before testing it in more severe indications, and to evaluate whether lowering CRP correlates with an improvement in RA symptoms.  The study accomplished its goals.  We are pleased with the consistency of CRP lowering across all of our clinical studies, but we are disappointed that we did not see a greater impact on RA symptoms in these patients," said Richard Geary, Ph.D., senior vice president of development at Isis.  "While we do not plan to further develop ISIS-CRPRx for RA, we do plan to continue to evaluate ISIS-CRPRx to treat other diseases."

The Phase 2 study was a randomized, placebo-controlled, multiple-dose study in patients with RA who had chronically elevated CRP.  In this study, 51 patients received 100 mg, 200 mg or 400 mg dose of ISIS-CRPRx or placebo for 12 weeks.  Patients in the study treated with ISIS-CRPRx achieved substantial, dose-dependent reductions in CRP early in treatment that were prolonged through the treatment process.  Patients also experienced improvements in the signs and symptoms of RA, as measured by ACR20 and ACR50 scores.  These improvements correlated with reductions in CRP, but were not sufficiently greater than improvements observed in the placebo groups to justify further development of ISIS-CRPRx for RA. 

ABOUT ISIS PHARMACEUTICALS, INC.
Isis is exploiting its leadership position in antisense technology to discover and develop novel drugs for its product pipeline and for its partners.  Isis' broad pipeline consists of 28 drugs to treat a wide variety of diseases with an emphasis on cardiovascular, metabolic, severe and rare diseases, and cancer.  Isis' partner, Genzyme, is commercializing Isis' lead product, KYNAMRO™, in the United States for the treatment of patients with HoFH.  Genzyme is also pursuing marketing approval of KYNAMRO in other markets.  Isis' patents provide strong and extensive protection for its drugs and technology.  Additional information about Isis is available at www.isispharm.com.

ISIS PHARMACEUTICALS' FORWARD-LOOKING STATEMENT
This press release includes forward-looking statements regarding the development, activity, therapeutic potential and safety of ISIS-CRPRx.  Any statement describing Isis' goals, expectations, financial or other projections, intentions or beliefs, including the commercial potential of KYNAMRO, is a forward-looking statement and should be considered an at-risk statement.  Such statements are subject to certain risks and uncertainties, particularly those inherent in the process of discovering, developing and commercializing drugs that are safe and effective for use as human therapeutics, and in the endeavor of building a business around such drugs.  Isis' forward-looking statements also involve assumptions that, if they never materialize or prove correct, could cause its results to differ materially from those expressed or implied by such forward-looking statements.  Although Isis' forward-looking statements reflect the good faith judgment of its management, these statements are based only on facts and factors currently known by Isis.  As a result, you are cautioned not to rely on these forward-looking statements.  These and other risks concerning Isis' programs are described in additional detail in Isis' annual report on Form 10-K for the year ended December 31, 2012 and its most recent quarterly report on Form 10-Q, which are on file with the SEC. Copies of these and other documents are available from the Company.

Isis Pharmaceuticals® is a registered trademark of Isis Pharmaceuticals, Inc.  KYNAMRO™ is a trademark of Genzyme Corporation.


'/>"/>
SOURCE Isis Pharmaceuticals, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. Intercept Pharmaceuticals to Present at the Wedbush Securities Life Sciences Management Access Conference
2. GW Pharmaceuticals Announces Results of MS Spasticity Study Confirming Sativex Has No Long-Term Negative Effect on Cognition
3. GW Pharmaceuticals plc Reports 2013 Third Quarter Financial Results
4. AcelRx Pharmaceuticals to Hold Second Quarter 2013 Financial Results Conference Call and Webcast on August 12, 2013
5. Radiopharmaceuticals Market - Global Industry Analysis, Size, Share, Trends And Forecast, 2012 - 2018
6. OPTIMER PHARMACEUTICALS SHAREHOLDER ALERT: Levi & Korsinsky Investigates Possible Breaches of Fiduciary Duty by Board of Optimer Pharmaceuticals, Inc. in Connection with Sale of Company to Cubist Pharmaceuticals, Inc.
7. Arena Pharmaceuticals Provides Corporate Update and Reports Second Quarter 2013 Financial Results
8. Auxilium Pharmaceuticals, Inc, Announces Second Quarter 2013 Financial Results
9. Cadence Pharmaceuticals Reports Second Quarter 2013 Financial Results
10. Arisaph Pharmaceuticals Awarded Phase I STTR Grant To Develop Small Molecule Immune Modulators
11. Avion Pharmaceuticals, LLC, receives top accolades for trade and marketing achievements at the 11th Annual American Business Awards (The "Stevie Awards")
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/16/2019)... ... August 16, 2019 , ... ... received FDA approval, providing an alternative that both corrects the curve and maintains ... uses patented methods and techniques developed by medical staff of Shriners Hospitals for ...
(Date:8/16/2019)... ... August 16, 2019 , ... The American ... Emergency Physicians (SBEP) of Indiana as a member group. , SBEP is a ... Bend. , SBEP sought out the AAEM-PG for administrative and practice management ...
(Date:8/16/2019)... ... 2019 , ... Gainesville Dental Group , located at ... practice that serves the Gainesville community with an extensive menu of dental care ... dental care. The well-established practice is led by a team of highly skilled ...
Breaking Medicine Technology:
(Date:8/19/2019)... ... ... A July 26 article on Reader’s Digest discusses how at ... a day. The acknowledges that, with dogs not always cooperating with being brushed, many ... at least twice a week is likely enough to keep canines healthy. The article ...
(Date:8/16/2019)... ... August 16, 2019 , ... Inc. magazine today revealed that ... prestigious ranking of the nation’s fastest-growing private companies. The list represents a unique ... independent small businesses. Microsoft, Dell, Domino’s Pizza, Pandora, Timberland, LinkedIn, Yelp, Zillow, and ...
(Date:8/16/2019)... ... August 16, 2019 , ... Dr. Demetri Arnaoutakis, a board-certified ... Beauty Network. , The Haute Beauty Network, well known for its exclusive and ... hair restoration expert and our newest addition to the Haute Beauty members-only network. ...
(Date:8/15/2019)... ... August 15, 2019 , ... Heritage Woods of Rockford ... for Assisted Living (NCAL). , This award is part of the NCAL Awards Program, ... profession. , “The common element among this year’s recipients is that they all go ...
(Date:8/14/2019)... ... August 13, 2019 , ... New Hampshire-based Vera Roasting ... today announced an expansion of its line of CBD-infused coffees with the release of ... in a 12-oz bag. , “We are excited to expand our CBD-infused product ...
Breaking Medicine News(10 mins):