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Isis Pharmaceuticals Initiates Phase 2 Study Of ISIS-CRP Rx In Patients With Atrial Fibrillation
Date:2/26/2013

s of CRP are predictive of severity of disease."

The Phase 2 study is a randomized, placebo-controlled, multiple-dose study evaluating the safety and efficacy of ISIS-CRPRx as a single agent in approximately 20 patients with AF who have pacemakers. The study is designed to evaluate the effects of ISIS-CRPRx on the frequency and duration of AF episodes. In addition to studying ISIS-CRPRx in AF, Isis is also currently evaluating ISIS-CRPRx in a Phase 2 study in patients with rheumatoid arthritis (RA), where CRP is chronically elevated. Top-line data from the Phase 2 RA study is planned for the middle of this year.

"ISIS-CRPRx is the first drug to test the hypothesis that lowering CRP levels could produce therapeutic benefit to patients. Although we are currently only evaluating ISIS-CRPRx in patients with rheumatoid arthritis and AF, if we are successful in demonstrating a significant benefit to lowering CRP in one or both of these diseases, there is a significant potential for ISIS-CRPRx to have broad application in numerous diseases with large commercial opportunity," concluded Lynne Parshall , chief operating officer at Isis.

ABOUT ISIS-CRPRx
ISIS-CRPRx­ is an antisense drug that is designed to inhibit the production of C-reactive protein (CRP).  For many years, CRP has been used as a clinical biomarker of diseases with an inflammatory component, such as cardiovascular disease, Crohn's disease, RA and end-stage renal disease.  Elevated levels of CRP have been linked to coronary artery disease and a growing body of evidence from clinical trials implicated CRP in cardiovascular disease progression.  Although CRP's active participation in these diseases remains to be determined, several lines of evidence support a causal role of CRP in disease, suggesting that it may be therapeutic
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SOURCE Isis Pharmaceuticals, Inc.
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