Navigation Links
Isis Pharmaceuticals Initiates Phase 2 Study Of ISIS-CRP Rx In Patients With Atrial Fibrillation
Date:2/26/2013

s of CRP are predictive of severity of disease."

The Phase 2 study is a randomized, placebo-controlled, multiple-dose study evaluating the safety and efficacy of ISIS-CRPRx as a single agent in approximately 20 patients with AF who have pacemakers. The study is designed to evaluate the effects of ISIS-CRPRx on the frequency and duration of AF episodes. In addition to studying ISIS-CRPRx in AF, Isis is also currently evaluating ISIS-CRPRx in a Phase 2 study in patients with rheumatoid arthritis (RA), where CRP is chronically elevated. Top-line data from the Phase 2 RA study is planned for the middle of this year.

"ISIS-CRPRx is the first drug to test the hypothesis that lowering CRP levels could produce therapeutic benefit to patients. Although we are currently only evaluating ISIS-CRPRx in patients with rheumatoid arthritis and AF, if we are successful in demonstrating a significant benefit to lowering CRP in one or both of these diseases, there is a significant potential for ISIS-CRPRx to have broad application in numerous diseases with large commercial opportunity," concluded Lynne Parshall , chief operating officer at Isis.

ABOUT ISIS-CRPRx
ISIS-CRPRx­ is an antisense drug that is designed to inhibit the production of C-reactive protein (CRP).  For many years, CRP has been used as a clinical biomarker of diseases with an inflammatory component, such as cardiovascular disease, Crohn's disease, RA and end-stage renal disease.  Elevated levels of CRP have been linked to coronary artery disease and a growing body of evidence from clinical trials implicated CRP in cardiovascular disease progression.  Although CRP's active participation in these diseases remains to be determined, several lines of evidence support a causal role of CRP in disease, suggesting that it may be therapeutic
'/>"/>

SOURCE Isis Pharmaceuticals, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Alexza Pharmaceuticals Corporate Presentation to Be Webcast at Three Upcoming Investor Conferences
2. Arena Pharmaceuticals to Host Corporate Update and Financial Results Conference Call and Webcast on Monday, March 4
3. DelMar Pharmaceuticals Announces $1.6 Million Closing in Private Placement
4. Reckitt Benckiser Pharmaceuticals Inc. Receives FDA Response to Citizens Petition
5. Keryx Biopharmaceuticals to Present at the Citigroup 2013 Global Healthcare Conference
6. Partnerships, Licensing, Investments and M&A Deals and Trends in Pharmaceuticals - Q4 2012
7. Tomorrows Outlook in Todays Market - Research Report on Toyota Motor Corporation, Honda Motor Co., Ltd., Yahoo! Inc., AOL, Inc. and Aegerion Pharmaceuticals, Inc.
8. Webcast Alert: Isis Pharmaceuticals 2012 Financial Results and Highlights Conference Call
9. Lexicon Pharmaceuticals Provides Clinical Pipeline Update And Reports 2012 Fourth Quarter And Full Year Financial Results
10. Zacks Bull and Bear of the Day Highlights: Fortune Brands Home & Security, Wal-Mart Stores, Regeneron Pharmaceuticals, Bayer and Array Biopharma
11. Top Active Companies to Watch: Crown Marketing, Herbalife, Novogen, GNC, Pfizer and Infinity Pharmaceuticals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... 29, 2014 Diseases largely eradicated in ... are returning. Measles was declared eliminated in 2000, yet ... of August 15—the highest incidence in 20 years. In ... declared whooping cough a problem of "epidemic proportions." ... and dying from these preventable diseases—in part because some ...
(Date:8/29/2014)... , Aug. 29, 2014 /PRNewswire-iReach/ -- ChemImage will present ... Australian and New Zealand Forensic Science Society,s 22 ... in Adelaide, Australia .  Forensic ... the advancements that hyperspectral imaging can bring to ... Beckstead , Director of Product Development at ChemImage, ...
(Date:8/29/2014)... Aug. 29, 2014  In part four ... a hospital pharmacy as a strategic asset, Mary ... leader for Cardinal Health,s Innovation Delivery Solutions business, discusses ... benefit both hospitals and patients. "Every hospital ... part of their job in a value-based healthcare world," ...
Breaking Medicine Technology:Vaccines at the Crossroads: Outbreaks On the Rise Across America 2Vaccines at the Crossroads: Outbreaks On the Rise Across America 3ChemImage to Discuss Hyperspectral Imaging for Forensic Investigation at the ANZFSS 22nd International Symposium on the Forensic Sciences 2ChemImage to Discuss Hyperspectral Imaging for Forensic Investigation at the ANZFSS 22nd International Symposium on the Forensic Sciences 3Five Ways Hospital Pharmacies Can Fulfill Their Quality Care Mission 2Five Ways Hospital Pharmacies Can Fulfill Their Quality Care Mission 3Five Ways Hospital Pharmacies Can Fulfill Their Quality Care Mission 4
(Date:9/1/2014)... 2014: Daily fruit consumption cuts the risk of cardiovascular ... presented at ESC Congress today by Dr Huaidong Du ... follow-up study of nearly 0.5 million people in the ... ate, the more their risk of CVD declined. , ... and stroke, is the leading cause of death worldwide. ...
(Date:9/1/2014)... (PRWEB) September 01, 2014 As well ... training, Derek is currently pursuing counselor certification in Louisiana. ... advance through the CPI training program as well as ... I have grown both personally and professionally. I ... I am competently able to do so. As ...
(Date:9/1/2014)... September 01, 2014 BCC Research ( ... BLOOD-BRAIN BARRIER TECHNOLOGIES AND GLOBAL MARKETS , the global ... in 2013 and is expected to reach $38.7 million ... $471.5 million by 2019, which is equivalent to 64.9% ... The receptor-mediated transport (RMT) segment is forecasted to grow ...
(Date:9/1/2014)... 2014 In honor of National Take Your Cat ... Emergency & Referral Center of Minnesota (AERC) is offering a few ... their cats. , Many people don’t take their cat to the ... hassle,” but they wouldn’t decide not to take their kid to ... The same goes for pets. Just like people want their loved ...
(Date:9/1/2014)... Registration is now open for the 4th Annual Harmon Meadow ... held on Sunday, September 21, 2014. The event will be ... Secaucus, New Jersey. All proceeds from the race will benefit ... a sense of self, restoring the family unit, and restoring ... General registration is $30 with special pricing for veterans, military ...
Breaking Medicine News(10 mins):Health News:Fruit consumption cuts CVD risk by up to 40 percent 2Health News:Fruit consumption cuts CVD risk by up to 40 percent 3Health News:Narconon Louisiana Announces New Certifications For Staff 2Health News:Global Market for Blood-Brain Barrier (BBB) Technology to Reach $471.5 Million in 2019; Highest CAGR Growth in Latin American Market With 10.5% 2Health News:Global Market for Blood-Brain Barrier (BBB) Technology to Reach $471.5 Million in 2019; Highest CAGR Growth in Latin American Market With 10.5% 3Health News:Animal Emergency & Referral Center of Minnesota Celebrates National Take Your Cat to the Vet Day 2Health News:Animal Emergency & Referral Center of Minnesota Celebrates National Take Your Cat to the Vet Day 3Health News:Hope For The Warriors New Jersey Run to Honor Wounded and Families of the Fallen 2
... abandoned again! WEST PALM BEACH, Fla., April 30 ... civil rights and negligence lawsuit in New York District ... Administration and four other agencies for failure to prevent ... foster parent.Identified in the filing only by their initials, ...
... in daily life: 56 percent of workers use one ... one. Arthritis is a leading cause of work disability, ... physically demanding jobs, and may select jobs that appear ... is a risk factor for pain and musculoskeletal disorders ...
... and others?,What can I do to prevent spreading swine flu? ... the threatening pandemic of "Swine,Flu", where time is of essence ... The Internet News Distribution Channel FEEDZILLA updates news ... "Help stop the,Flu" is available as a widget to be ...
... April 30 The following is being issued by Randall ... Noon, protests will occur on Notre Dame campus ... least one dozen pro-life activists will push baby carriages holding ... the lunch hour on May 1.In addition, life size images ...
... But few options require balancing dangers and benefits, experts ... The risk of developing leukemia from a drug used ... than previously reported, new research shows. , Italian researchers ... an estimated 7.4 people will develop acute leukemia, compared ...
... Shamir Optical Industry Ltd. (Nasdaq: SHMR ) ... technology to the ophthalmic lens market, today announced that it ... chief executive officer, replacing Mr. Eyal Hayardeny who has resigned ... become effective on July 1, 2009.Mr. Netzer currently serves as ...
Cached Medicine News:Health News:Severely Abused Foster Children Sue New York City Child Welfare Agencies After their Failure to Help Them 2Health News:Computer use significantly affected by arthritis 2Health News:Computer use significantly affected by arthritis 3Health News:Leukemia Risk From MS Drug May Be Up 2Health News:Leukemia Risk From MS Drug May Be Up 3Health News:Shamir Optical Industry Ltd. Appoints Amos Netzer as New Chief Executive Officer 2Health News:Shamir Optical Industry Ltd. Appoints Amos Netzer as New Chief Executive Officer 3
The best combination with the Haag-Streit 900 Slitlamps. For examination of the entire fundus, the vitreous and the iridocorneal angle. The classic Goldmann Glass....
This table provides the user with a moderatelypriced, yet fully versatile, electric table which will accept most HAAG-STREIT instruments as well as many of those from other ophthalmic manufacturers....
... The design philosophy of the Uniflex® ... system that could be used for the ... on a closed interlocking intramedullary rod, the ... understanding of the biology of fracture healing ...
... in the Magnes line of biomagnetometer systems, with ... cortical coverage, provides the highest detector density available, ... a wide range of neuronal activity. The Magnes ... configurations and can be equipped with radial magnetometers, ...
Medicine Products: