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Isis Pharmaceuticals Initiates Phase 2 Study Of ISIS-CRP Rx In Patients With Atrial Fibrillation
Date:2/26/2013

CARLSBAD, Calif., Feb. 26, 2013 /PRNewswire/ -- Isis Pharmaceuticals, Inc. (NASDAQ: ISIS) announced the initiation of a Phase 2 study evaluating ISIS-CRPRx in patients with paroxysmal atrial fibrillation. Atrial fibrillation (AF) involves an irregular and often rapid heart rate that commonly causes poor blood flow to the body.  Paroxysmal AF is a type of AF characterized by unpredictable episodes of AF that can occur as frequently as every day. Patients with AF can experience chest palpitations, chest pain, weakness and decreased blood pressure during an event. While the cause of paroxysmal AF is not known, elevated levels of CRP are associated with an increase in the severity of AF episodes. ISIS-CRPRx is being evaluated in patients with AF to measure the effect of lowering CRP on the frequency and duration of the episodes.

"CRP is elevated in many inflammatory disorders and can also be elevated in diseases with inflammatory components, like AF.  Elevation of CRP in these diseases is usually associated with increased disease burden and worse disease outcome.  In this study, we will evaluate the effect of selectively lowering CRP on the severity of AF in patients who are prone to frequent and unpredictable AF events.  By selectively lowering CRP with ISIS-CRPRx, we hope to observe a decrease in the frequency and duration of AF events in these patients," said Richard Geary , Ph.D., senior vice president of development at Isis. "ISIS-CRPRx is the first drug to be evaluated in clinical studies that can selectively reduce CRP.  In our Phase 1 studies, we observed selective, dose-dependent reduction of CRP in healthy volunteers.  Our Phase 2 program is designed to provide us with proof-of-concept data in diseases where elevated level
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SOURCE Isis Pharmaceuticals, Inc.
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