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Isis Pharmaceuticals Earns $6 Million Payment from AstraZeneca
Date:6/6/2013

CARLSBAD, Calif., June 6, 2013 /PRNewswire/ -- Isis Pharmaceuticals, Inc. (NASDAQ: ISIS) announced today that it has earned a $6 million payment from AstraZeneca related to continuation of the research collaboration between Isis and AstraZeneca to discover and develop novel antisense therapeutics to treat cancer.  In addition to the research collaboration, which includes three cancer targets, Isis and AstraZeneca are developing two antisense drugs, ISIS-ARRx and ISIS-STAT3Rx, discovered by Isis and licensed to AstraZeneca for the treatment of cancer. 

"We are pleased to be working with AstraZeneca, a global leader in oncology, and are already benefiting from our collaborative efforts.  In just six months, we have selected a new development candidate, ISIS-ARRx, to move forward into clinical development to treat patients with prostate cancer and initiated two clinical studies on ISIS-STAT3Rx in patients with advanced lymphomas and liver cancer.  We are also making progress selecting the next three oncology targets that we and AstraZeneca will focus our research efforts toward," said B. Lynne Parshall , chief operating officer at Isis.  "The success of this collaboration is an example of how our partnering strategy enables us to develop a broad pipeline of antisense drugs in a variety of therapeutic areas.  Our oncology franchise consists of five antisense drugs in development to treat patients with a variety of cancers.  We look forward to continuing to expand our cancer franchise with AstraZeneca as we move our research programs forward toward development."

In December 2012, Isis entered into a collaboration with AstraZeneca to discover and develop antisense drugs to treat cancer. The collaboration combines AstraZeneca's experience and
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SOURCE Isis Pharmaceuticals, Inc.
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