Navigation Links
Isis Pharmaceuticals Demonstrates The Potential Of Single-Stranded RNA-Like Antisense Technology To Activate The RNAi Pathway
Date:8/30/2012

CARLSBAD, Calif., Aug. 30, 2012 /PRNewswire/ -- Isis Pharmaceuticals, Inc. (NASDAQ: ISIS) announced today the publication of two papers in the journal Cell demonstrating that single-stranded short interfering RNA (ss-siRNA) molecules distributed broadly, activated the RNA interference (RNAi) pathway and reduced expression of targeted genes in animal models.  The RNAi pathway is a mechanism that can be used to inhibit expression of genes.  The RNAi pathway has typically been engaged by short double-stranded RNAs (dsRNA).  Once engaged, the RNAi mechanism removes the 'sense' strand of the dsRNA leaving a functional 'antisense' single-stranded RNA to bind to the target mRNA and cause degradation.  In these studies, Isis scientists and collaborators demonstrated that ss-siRNA molecules can effectively trigger the RNAi pathway and selectively inhibit the expression of a targeted gene. 

In the published study titled 'Single-stranded siRNAs activate RNAi in animals', Isis scientists evaluated the absorption, distribution, metabolism and activity of the ss-siRNAs designed to utilize the RNAi pathway.   These data show that single-stranded RNA-like antisense oligonucleotides are broadly distributed to and active in multiple organs and effectively engage and trigger the RNAi pathway without the need for complex formulations or delivery vehicles typically necessary for double-stranded RNAi molecules. 

"Double-stranded siRNA drugs require complex formulations to achieve sufficient delivery for systemic activity.  This requirement has severely limited the development of safe and effective drugs that work through the RNAi pathway.  In contrast, single-stranded RNA-like antisense drugs can be administered subcutaneously and distribute to tissues without the need for formulations.  In addition, approaching RNAi with singl
'/>"/>

SOURCE Isis Pharmaceuticals, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Savient Pharmaceuticals to Hold First Quarter 2012 Financial Results Conference Call on Wednesday, May 9, 2012
2. Auxilium Pharmaceuticals to Present at the Deutsche Bank 37th Annual Healthcare Conference
3. Nouveau Life Pharmaceuticals (HRID) Contracts with U.S. Manufacturer to Produce New Female Supplement
4. BioElectronics Survey Indicates a Five-Fold Superior Pain Relief Compared to OTC Pharmaceuticals
5. Icahn Issues Statement Regarding Amylin Pharmaceuticals
6. Almost 50 Percent of the Glaucoma Patient Population Remains Untreated, Signifying a Vast Market for Glaucoma Pharmaceuticals, Finds Frost & Sullivan
7. Omthera Pharmaceuticals Announces Positive Top-Line Results from Phase 3 EVOLVE Study
8. Onyx Pharmaceuticals Announces FDA Advisory Committee to Review Carfilzomib for the Treatment of Patients with Relapsed and Refractory Multiple Myeloma
9. Jazz Pharmaceuticals Announces First Quarter 2012 Financial Results Conference Call On May 8, 2012
10. Inovio Pharmaceuticals Granted U.S. Patent Protection for Synthetic Vaccine for Cervical Dysplasia and Cancer
11. Avanir Pharmaceuticals To Present at Three Conferences In May
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... 2014  CVS Caremark Corporation (NYSE: CVS ... August 5, 2014, at 8:30 a.m. (EDT) with analysts ... results. An audio webcast of the conference ... portion of the CVS Caremark website for all interested ... This webcast will be archived and available on the ...
(Date:7/25/2014)...  Acsis Inc., the market leader for supply ... recently posted an article, "Future of Running ... needs for companies, extended supply chain, and explains ... no longer work today.  The article explains how ... mobile technology, machine to machine (M2M) connectivity, and ...
(Date:7/25/2014)... 2014 Research and Markets has ... Devices Market 2014-2018" report to their offering. ... Ophthalmic Diagnostic Device An ophthalmic diagnostic ... defect or deficiency in the human visual pathway. Ophthalmic ... as presbyopia, cataracts, glaucoma, retinal disorders, conjunctivitis, and dry ...
Breaking Medicine Technology:Acsis Addresses Questions on the Modern Supply Chain 2Global Ophthalmic Diagnostic Devices Market 2014-2018: Key Vendors are Alcon, Carl Zeiss, Haag-Streit and Topcon 2
... 16 Medicare has been touting the merits of the "competitive" bidding program for durable, or home medical equipment ... facts that exaggerate the benefits and ignore the severe shortcomings of the program. , ... ... , ...
... Pharmaceuticals Inc. (Nasdaq: OSIP ) that it will nominate a full and competing slate of independent directors at OSI Pharmaceuticals, 2010 annual stockholders, meeting. , ... , ... ... ...
Cached Medicine Technology:Discussion of Medicare's 'Competitive' Bidding Program for Home Medical Equipment is Plagued by Myths and Misinformation 2Discussion of Medicare's 'Competitive' Bidding Program for Home Medical Equipment is Plagued by Myths and Misinformation 3Discussion of Medicare's 'Competitive' Bidding Program for Home Medical Equipment is Plagued by Myths and Misinformation 4Discussion of Medicare's 'Competitive' Bidding Program for Home Medical Equipment is Plagued by Myths and Misinformation 5Astellas Announces Full Slate of Independent Director Nominees for Election at OSI Pharmaceuticals' 2010 Annual Stockholders Meeting 2Astellas Announces Full Slate of Independent Director Nominees for Election at OSI Pharmaceuticals' 2010 Annual Stockholders Meeting 3Astellas Announces Full Slate of Independent Director Nominees for Election at OSI Pharmaceuticals' 2010 Annual Stockholders Meeting 4Astellas Announces Full Slate of Independent Director Nominees for Election at OSI Pharmaceuticals' 2010 Annual Stockholders Meeting 5Astellas Announces Full Slate of Independent Director Nominees for Election at OSI Pharmaceuticals' 2010 Annual Stockholders Meeting 6Astellas Announces Full Slate of Independent Director Nominees for Election at OSI Pharmaceuticals' 2010 Annual Stockholders Meeting 7Astellas Announces Full Slate of Independent Director Nominees for Election at OSI Pharmaceuticals' 2010 Annual Stockholders Meeting 8Astellas Announces Full Slate of Independent Director Nominees for Election at OSI Pharmaceuticals' 2010 Annual Stockholders Meeting 9Astellas Announces Full Slate of Independent Director Nominees for Election at OSI Pharmaceuticals' 2010 Annual Stockholders Meeting 10
(Date:7/28/2014)... 2014 Maternal and Family Health Services ... which will be presented at the agency’s 43rd Annual ... at the Westmoreland Club in Wilkes-Barre. , The late ... long-time employee of MFHS. She dedicated her life ... health advocate, and champion for women, children and families ...
(Date:7/28/2014)... study has found that following a healthy lifestyle may ... syndrome. Published early online in CANCER , a ... indicate that children with cancer and adults who had ... how their lifestyle may influence their long-term health. ... to be at increased risk for the metabolic syndrome, ...
(Date:7/28/2014)... 28, 2014 As health insurers design ... to private exchanges. “Private Exchange Strategies for Insurers: ... from Atlantic Information Services, will provide answers to the ... for the future. , Barbara Gniewek, Jonathan Har-Even and ... experience in the private exchange sector — will provide ...
(Date:7/28/2014)... 28, 2014 Mitul R. Patel, DDS ... at the MGE Management Experts Benefit Dinner May 30, ... joined the Dentists to raise funds for the Improving ... Girls Clubs and Youth Programs across America. The funds ... with books and audio books to directly tackle illiteracy ...
(Date:7/28/2014)... Cuidado Casero , an organization of Medicare certified agencies ... Texas, New Mexico, New Jersey, Virginia, and Puerto Rico, was ... of PAM’s 2014 Gala. , North Texas PAMS is ... Texas chapter was created by a handful of Peruvian physicians ... care for the indigent in Peru. The chapter is developing ...
Breaking Medicine News(10 mins):Health News:MFHS Seeking Nominations for Rose Allan Tucker Award 2Health News:Lifestyle choices may affect the long-term heart health of childhood cancer survivors 2Health News:Three PwC Consultants to Offer Insurers Successful Strategies for Private Exchanges 2Health News:Mitul R. Patel, DDS Successfully Attacks a Major Source of Economic Destruction in the Battle Against Illiteracy and Poverty 2Health News:Mitul R. Patel, DDS Successfully Attacks a Major Source of Economic Destruction in the Battle Against Illiteracy and Poverty 3Health News:Cuidado Casero Sponsors Peruvian American Medical Society (PAMS) Gala 2
... traditional medicinal system, the Indian Council of Medical Research (ICMR) ... develop drugs //from medicinal plants or multi-herb formulations that have ... valid for next five years was signed by ICMR Director ... K Gupta., ,As per the MoU, the ICMR will ...
... shortfall of the tissue culture variety of anti-rabies vaccine, ... of the restricted nerve tissue variety vaccine till the ... minister Surjyakanta Mishra told reporters here today that the ... few years ago citing side-effects., ,"However, since the ...
... shown by an increased nighttime BP than with a traditional ... researchers at Uppsala University revealed that a high blood pressure ... heart failure. ,Congestive heart failure (CHF) is ... Once diagnosed as having CHF, patients have a 1 in ...
... demand for traditional Indian medicine, a four-year degree course ... University (JU) for the first time in eastern India//. ... second of its kind in the country after Gujarat, ... Sciences (BIPS) in joint venture with West Bengal Health ...
... women has shown that those who indulged in six or ... 3 percent reduction in risk of type 2 diabetes, vis ... scientists were not able to place their finger on the ... they strongly feel that the presence of antioxidants and minerals ...
... MMR vaccine has been shrouded in controversy. Now, Britain's reputed ... to the raging //debates over this vaccine. ,Infact they have ... threat to young lives by forsaking the triple shots of ... and the media to defuse the entire furore over the ...
Cached Medicine News:Health News:Increased Nighttime BP, a Significant Predictor of Congestive Heart Failure 2
All-silicone construction provides maximum softness and biocompatibility for enhanced patient comfort. Supplied sterile in peel-open packages. Intended for one-time use....
Used to provide bladder drainage by percutaneous placement of a balloon catheter. Supplied sterile in peel-open packages. Intended for one-time use....
Used to establish and temporarily maintain suprapubic access during endoscopic procedures. Supplied sterile in peel-open packages. Intended for one-time use....
Used for pulling sutures from a vaginal incision into the suprapubic area during bladder suspension surgery. The double needle design permits simultaneous suture placement. Supplied sterile in peel-o...
Medicine Products: