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Isis Pharmaceuticals Announces the Initiation of a Clinical Study of ISIS-STAT3 Rx in Patients with Liver Cancer
Date:5/6/2013

The Phase 1b/2a study will evaluate the safety and efficacy of ISIS-STAT3Rx in patients with HCC who have failed first-line therapy.  The endpoints for the study include measurements of anti-tumor activity, STAT3 protein levels in tumor biopsies and STAT3-related biomarkers.  The study will also evaluate safety.   Although HCC is common, it is considered a very difficult to treat cancer that does not respond well to chemotherapy. 

"STAT3 is important for the growth, invasiveness and metastases of many types of cancer, which makes it a very attractive target. The potency we have observed in our preclinical cancer studies and the early evidence of clinical activity we observed in our Phase 1 study suggest that ISIS-STAT3Rx could be an effective anti-tumor agent that is broadly applicable to many different types of cancer," said Brett Monia , Ph.D., senior vice president, antisense drug discovery at Isis. 

ABOUT ISIS-STAT3Rx
ISIS-STAT3Rx, also referred to as AZD9150, is designed to specifically reduce the production of signal transducer and activator of transcription 3 (STAT3).  STAT3 is a gene that blocks natural cell death and is critical for tumor cell growth and survival.  Inhibition of STAT3 has been shown to block the induction of tumor-associated cytokines involved in the progression of cancer, such as IL-6, IL-1, TGFb, and IL-10, which could serve as important biomarkers in clinical studies.  ISIS-STAT3Rx is the first drug in Isis' pipeline that incorporates Isis' Generation 2.5 chemistry, which was developed to increase potency of antisense drugs thereby creating opportunities for drugs like ISIS-STAT3Rx to be effective in more difficult to treat cancers.  In a Phase 1 safety study, ISIS-STAT3Rx treatment produced an acceptable safety profile and resulted in sustained responses in t
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SOURCE Isis Pharmaceuticals, Inc.
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