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Isis Initiates Phase 2 Study Of ISIS-FXIRX In Patients Undergoing Knee Replacement Surgery
Date:10/29/2012

activity with no bleeding events observed. 

"ISIS-FXIRx is one of many maturing drugs in our pipeline and represents the broad applicability of our technology to develop novel drugs for many different diseases.  We believe that the safety profile observed thus far coupled with the robust activity we have seen for ISIS-FXIRx in both our Phase 1 study and preclinically, suggest that this drug could have a significant benefit for patients at risk of a thrombotic event.  Given the mechanism of Factor XI inhibition, we believe that the drug could be used broadly to prevent deep vein thrombosis or pulmonary embolism in many different therapeutic settings, including stroke, myocardial infarction and with surgeries such as knee or hip replacement, where additional safe and effective anti-thrombotic drugs are needed.  Our earlier work suggests that ISIS-FXIRx could be used in combination with existing therapies," said Sanjay Bhanot, M.D., Ph.D., vice president, clinical development and translational medicine at Isis. 

"TKA is one of the leading surgeries performed worldwide each year and is associated with a high incidence of venous thromboembolism," said Brett Monia, Ph.D., senior vice president, antisense drug discovery at Isis.  "By evaluating our drug in these patients, we will be able to directly compare the activity and safety of ISIS-FXIRx to a commonly prescribed anti-coagulant, enoxaparin.  With this proof-of-value data in hand, we believe that we will have a robust and comprehensive data package representing a significant licensing opportunity for us."

ABOUT ISIS PHARMACEUTICALS, INC.
Isis is exploiting its leadership position in antisense technology to discover and develop novel drugs for its product pipeline and for its partners.  Isis' broad pipeline consists of 25 drugs to treat a wide variety of diseases with an emphasis on cardiovascular, metabolic,
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SOURCE Isis Pharmaceuticals, Inc.
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