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Isis Initiates Phase 1 Study of ISIS-PTP1BRx to Treat Type 2 Diabetes
Date:7/21/2011

were taking sulfonylureas.  Those studies also showed that PTP-1B inhibition did not cause weight gain, another substantial advantage in the treatment of diabetic patients who are frequently obese and at high cardiovascular risk.  The data from these studies support the development of ISIS-PTP1BRx and should allow a very rapid route to clinical proof-of-concept.    

ISIS-PTP1BRx has the potential to be broadly useful in combination with most of the other commonly used drugs to treat patients with diabetes, including insulin, GLP-1 agonists, and more traditional drugs like metformin.  The initial clinical development plan for ISIS-PTP1BRx will focus on treating diabetic patients who are inadequately controlled on insulin, helping them utilize insulin more efficiently; and patients who are beginning to fail oral therapies, extending the time they have before becoming dependent on insulin.  

ABOUT ISIS-PTP1BRx

ISIS-PTP1BRx is an antisense drug that targets PTP-1B, a phosphatase that negatively regulates insulin receptor signaling and is responsible for turning off the activated insulin receptor.  Reducing PTP-1B enhances insulin activity. Scientists have long recognized PTP-1B as an attractive target to treat diabetes, but due to structural similarities among closely related proteins, pharmaceutical companies have had difficulty identifying small molecule drugs with sufficient specificity to be safe. ISIS-PTP1BRx selectively inhibits the production of PTP-1B without affecting other closely related proteins that, when inhibited, could lead to unwanted side effects. ISIS-PTP1BRx may offer new treatment to patients who do not respond adequately to currently available therapies such as glitazones, sulfonylureas, metformin, and GLP-1 based therapies, and has the potential to be used in combination with such other therapies.

ABOUT ISIS PHARMACEUTICALS, INC.

Isis is exploiting its leadership
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SOURCE Isis Pharmaceuticals, Inc.
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