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Isis Initiates Phase 1 Study of ISIS-APOA Rx to Treat Atherosclerosis
Date:4/3/2013

1 study of ISIS-APOARx is a blinded, placebo-controlled, dose-escalation study in approximately 56 healthy volunteers.  The study is designed to assess the safety, tolerability and pharmacokinetics of both single and multiple doses of ISIS-APOARx

ABOUT Lp(a)

Lp(a) is considered an independent risk factor for cardiovascular disease due to its association with an increased risk of coronary heart disease and atherosclerotic plaque formation.  Lp(a) is a lipoprotein particle that is assembled in the liver that consists of an LDL-C-like particle and apolipoprotein(a).  Lp(a) levels in blood can vary greatly between individuals due primarily to genetic variations in the gene that encodes for apolipoprotein(a).  As a result, Lp(a) levels are genetically determined, reached by the age of two and remain constant throughout the life of the individual.  Diet and lifestyle changes have little impact on Lp(a) levels and currently therapies are not able to adequately reduce elevated levels of Lp(a) to acceptable levels in patients who have severely elevated Lp(a).   As a general guideline for ideal Lp(a) levels, the European Atherosclerosis Society recommends that Lp(a) levels be less than or equal to 50 mg/dL.  ISIS-APOARx is designed to selectively reduce levels of Lp(a) by inhibiting the production of apolipoprotein(a).

ABOUT ISIS PHARMACEUTICALS, INC.

Isis is exploiting its leadership position in antisense technology to discover and develop novel drugs for its product pipeline and for its partners.  Isis' broad pipeline consists of 28 drugs to treat a wide variety of diseases with an emphasis on cardiovascular, metabolic, severe and rare diseases, and cancer.  Isis' partner, Genzyme, is commercializing Isis' lead product, KYNAMRO™, in the United States for the treatment of patients with HoFH.  Genzyme is also pursuing mar
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SOURCE Isis Pharmaceuticals Inc.
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